DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31357 and MAEA

DIOPT Version :9

Sequence 1:	NP_733044.1	Gene:	CG31357 / 326135	FlyBaseID:	FBgn0051357	Length:	394	Species:	Drosophila melanogaster
Sequence 2:	XP_006713912.1	Gene:	MAEA / 10296	HGNCID:	13731	Length:	450	Species:	Homo sapiens

Alignment Length:	365	Identity:	176/365 - (48%)
Similarity:	245/365 - (67%)	Gaps:	23/365 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 IKALEHATLKVPYEMLNKRFRSAQKIIDREVDQVINVSRQVEKALEAEEGPILAEVTKLVDNVAQ 68
            :|..|:.|||||||.||||||:|||.||||...|..|..::||.|..  .|.:..|..|:|.|.:
Human    14 LKVQEYPTLKVPYETLNKRFRAAQKNIDRETSHVTMVVAELEKTLSG--CPAVDSVVSLLDGVVE 76

  Fly    69 KLQVLKRKAEESINDELSVTQICKRKLDHLKGITPPSSVTGDLWQGSVDQ------WKRIRLDRL 127
            ||.||||||.|||..|....::|||:::|||             :.|.||      |||.|:||:
Human    77 KLSVLKRKAVESIQAEDESAKLCKRRIEHLK-------------EHSSDQPAAASVWKRKRMDRM 128

  Fly   128 VIEHLLRMGYYETAEELAAKSDVRHLTNLDIFQTSREVEDDLASHSTTKCVLWCIDNKSKLRKIN 192
            ::|||||.|||.||.:||.:|.:..|.|:::|.|::|||:.|....|..|:.||.||||:|||:.
Human   129 MVEHLLRCGYYNTAVKLARQSGIEDLVNIEMFLTAKEVEESLERRETATCLAWCHDNKSRLRKMK 193

  Fly   193 STIEFSLRVQEFIELVRQNQRFEAVKHSRRYFPAYEKTQLNEICHVMALLAYPADAQAEHYRKYM 257
            |.:|||||:||||||:|||:|.:||:|:|::|...|.:||:|:...|.:||:|.|.....|:..:
Human   194 SCLEFSLRIQEFIELIRQNKRLDAVRHARKHFSQAEGSQLDEVRQAMGMLAFPPDTHISPYKDLL 258

  Fly   258 DPQRWQKLVLDFRQENYRLFQLSSTSVFSAAVQAGLSALKTPHCYAQ--TCRNLNCPVCQEDLNR 320
            ||.||:.|:..||.:||||.||.:.|||:..:||||||:|||.||.:  :.::.:||||...||:
Human   259 DPARWRMLIQQFRYDNYRLHQLGNNSVFTLTLQAGLSAIKTPQCYKEDGSSKSPDCPVCSRSLNK 323

  Fly   321 IALKLPYSHCVQSRLICRVTGLPLNEHNQPMMLPNGQIFG 360
            :|..||.:||..|||:|:::|..:||:|.|||||||.::|
Human   324 LAQPLPMAHCANSRLVCKISGDVMNENNPPMMLPNGYVYG 363

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31357	NP_733044.1	LisH	119..150	CDD:128913	19/30 (63%)
		CLTH	158..300	CDD:287564	72/141 (51%)
		CTLH	158..215	CDD:128914	33/56 (59%)
		CRA	215..302	CDD:214806	40/86 (47%)
MAEA	XP_006713912.1	LisH	120..153	CDD:128913	19/32 (59%)
		CLTH	160..301	CDD:371161	72/140 (51%)
		RING-Ubox_Emp	336..>365	CDD:319573	16/28 (57%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165147971
Domainoid	1	1.000	162	1.000	Domainoid score	I3996
eggNOG	1	0.900	-	-		E1_KOG0396
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H4298
Inparanoid	1	1.050	374	1.000	Inparanoid score	I2111
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54998
OrthoDB	1	1.010	-	-		D1087488at2759
OrthoFinder	1	1.000	-	-		FOG0004704
OrthoInspector	1	1.000	-	-		oto90026
orthoMCL	1	0.900	-	-		OOG6_103231
Panther	1	1.100	-	-	LDO	PTHR12170
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R462
SonicParanoid	1	1.000	-	-		X3306
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.800