DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31343 and NPEPPS

DIOPT Version :9

Sequence 1:	NP_732652.1	Gene:	CG31343 / 326133	FlyBaseID:	FBgn0051343	Length:	961	Species:	Drosophila melanogaster
Sequence 2:	XP_016880861.1	Gene:	NPEPPS / 9520	HGNCID:	7900	Length:	924	Species:	Homo sapiens

Alignment Length:	986	Identity:	272/986 - (27%)
Similarity:	439/986 - (44%)	Gaps:	148/986 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 LLLAVCSLQARLILPLSLDDGQLETKGAALFATSRVDDNSAGNYRLPNTTEPESYNVELWTNVHN 77
            |||.|.|..:|         .:|.:.|.|.....|..:      |||....|.:|::.|..::.
Human    24 LLLLVFSRSSR---------RRLHSLGLAAMPEKRPFE------RLPADVSPINYSLCLKPDLL- 72

  Fly    78 GDTEFNGTVNIDIRVLNETSNITLHYRQTSNFEATIISRDVATPTAIPLTVTPELQRE------- 135
             |..|.|.:....:|...|:.|.::            ..|:...||   :..||...|
Human    73 -DFTFEGKLEAAAQVRQATNQIVMN------------CADIDIITA---SYAPEGDEEIHATGFN 121

  Fly   136 -----------FLVLTQTTAGEAFGANTNWTITINYTGIHRSDMGGFYISSYTDDDGEQHFLATT 189
                       |....||..|         |:.|::.|.....|.|||.|.||...||..:.|.|
Human   122 YQNEDEKVTLSFPSTLQTGTG---------TLKIDFVGELNDKMKGFYRSKYTTPSGEVRYAAVT 177

  Fly   190 QFESTNARHAFPCYDEPARRANFTITIHHDPSYTAISNMPV----------NTAATSSGVTAFQT 244
            |||:|:||.||||:||||.:|.|.|::.......|:|||.|          |.....     |..
Human   178 QFEATDARRAFPCWDEPAIKATFDISLVVPKDRVALSNMNVIDRKPYPDDENLVEVK-----FAR 237

  Fly   245 TPKMSTYLVAFIVSDFEST-TGELNGIRQRVFSRKGKQDQQEWALWSGLLVESSLASYFGVPFAL 308
            ||.||||||||:|.:::.. |...:|:..||::..||.:|.::||............||.||:.|
Human   238 TPVMSTYLVAFVVGEYDFVETRSKDGVCVRVYTPVGKAEQGKFALEVAAKTLPFYKDYFNVPYPL 302

  Fly   309 PKLDQAGIPDFSAGAMENWGLATYREQYMWWNKQNSTINLKTNIANIIGHEYAHMWFGDLVSIKW 373
            ||:|...|.||:|||||||||.||||..:..:.:||..:.:..:|.::|||.||.|||:||:::|
Human   303 PKIDLIAIADFAAGAMENWGLVTYRETALLIDPKNSCSSSRQWVALVVGHELAHQWFGNLVTMEW 367

  Fly   374 WTYLWLKEGFATLFSYESNDIAFPLWDTYQIFHVNDYNSALLNDALASAVPMTHYVQTPSEISNR 438
            ||:|||.||||:...|...|..||.:|.:..|...||..|...|||.::.|:...|..|||:...
Human   368 WTHLWLNEGFASWIEYLCVDHCFPEYDIWTQFVSADYTRAQELDALDNSHPIEVSVGHPSEVDEI 432

  Fly   439 YNTFSYAKPASVLYMFKNAWTDKVFRTGLNKYLTKNQYTSCDEWDLFASFQESADELGFTLPASV 503
            ::..||:|.|||:.|..:...||.|:.|:|.||||.|..:....||:.|.:.::.:       .:
Human   433 FDAISYSKGASVIRMLHDYIGDKDFKKGMNMYLTKFQQKNAATEDLWESLENASGK-------PI 490

  Fly   504 DDIFSSWSHQAGYPLLTVTRNY--NAGTITITQKRYVA--NKTDTNSATWYVPLNFATANKYDYR 564
            ..:.::|:.|.|:||:.|....  :...:.::||::.|  :....:...|.||:..:|:   :..
Human   491 AAVMNTWTKQMGFPLIYVEAEQVEDDRLLRLSQKKFCAGGSYVGEDCPQWMVPITISTS---EDP 552

  Fly   565 DTSATHYLLNVTETVISDVEASSDDWIIVNIQNSGYYRTLYDTQNYGLITAALK--SQPWRFHPR 627
            :.:....|::..|..:.......|.|:.:|:...|:|||.|.:.....:...::  |.|    |.
Human   553 NQAKLKILMDKPEMNVVLKNVKPDQWVKLNLGTVGFYRTQYSSAMLESLLPGIRDLSLP----PV 613

  Fly   628 NRAQLLYDTYIFVSTDRLSHSILLELLGYLTNEQQYAPWSTANTILTVYDRYLRGDDSYYNFQDF 692
            :|..|..|.:.......:|...:|:::....||..|..||..:..|.:....|...|.|...|:|
Human   614 DRLGLQNDLFSLARAGIISTVEVLKVMEAFVNEPNYTVWSDLSCNLGILSTLLSHTDFYEEIQEF 678

  Fly   693 VKRLIDPIFDKIGVNEIPGEHYLNNYLRIVLVSLACQVGSDDCYNQSANKLSEYLYNGTAIEATL 757
            ||.:..||.:::|.:..|||.:|:..||.:::....:.|......::..:..:::.....:.|.|
Human   679 VKDVFSPIGERLGWDPKPGEGHLDALLRGLVLGKLGKAGHKATLEEARRRFKDHVEGKQILSADL 743

  Fly   758 KTQAYCAGLR---STTNEIYSRV--QSDLLSSSDSTDRSLFISSLGCSGSTSQLLDFLR--LSLD 815
            ::..|...|:   .||.:|..::  |:|:....:..:|.|        |:| .|.|.::  |:..
Human   744 RSPVYLTVLKHGDGTTLDIMLKLHKQADMQEEKNRIERVL--------GAT-LLPDLIQKVLTFA 799

  Fly   816 TNNSLSYSERTSLLNSAYSRSEIGLTASLEFLESNWEAYANLSDSAKPLDAALRGIATYVVSEKQ 880
            .:..:...:..|::......|:.|..|:.:|::.|||...|            |....:::|...
Human   800 LSEEVRPQDTVSVIGGVAGGSKHGRKAAWKFIKDNWEELYN------------RYQGGFLISRLI 852

  Fly   881 KTR-----LNALVDVVEADGPSYINDDLS--TTIDSRITSNFAWLEVNRDPVLNWIEDSLKENGS 938
            |.:     :.||.|......|...:..||  |....|......|||..|
Human   853 KVQWLTPVIPALWDAEVGRSPEVGSSRLSWPTCYQLRDLQLIKWLERLR---------------- 901

  Fly   939 PSLTSSITTIL 949
              |:|.:|.:|
Human   902 --LSSRVTQLL 910

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31343	NP_732652.1	Peptidase_M1	57..446	CDD:279741	146/417 (35%)
		M1_APN_2	65..517	CDD:189008	163/480 (34%)
		ERAP1_C	591..886	CDD:288671	65/308 (21%)
NPEPPS	XP_016880861.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0308
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S1087
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X67
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.770