DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31343 and pepN

DIOPT Version :9

Sequence 1:	NP_732652.1	Gene:	CG31343 / 326133	FlyBaseID:	FBgn0051343	Length:	961	Species:	Drosophila melanogaster
Sequence 2:	NP_415452.1	Gene:	pepN / 947253	ECOCYCID:	EG10696	Length:	870	Species:	Escherichia coli

Alignment Length:	840	Identity:	177/840 - (21%)
Similarity:	287/840 - (34%)	Gaps:	225/840 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   189 TQFESTNARHAFPCYDEPARRANFTITIHHD----PSYTAISNMPVNTAATSSG---VTAFQTTP 246
            ||.|:...||.....|.|...|.||..|..|    |...:..|. |......:|   |......|
E. coli   118 TQCEAEGFRHITYYLDRPDVLARFTTKIIADKIKYPFLLSNGNR-VAQGELENGRHWVQWQDPFP 181

  Fly   247 KMSTYLVAFIVSDFE-----STTGELNGIRQRVFSRKGKQDQQEWALWSGLLVESSL---ASYFG 303
            | ..||.|.:..||:     .||.....:...::..:|..|:..||:.|   :::|:   ...||
E. coli   182 K-PCYLFALVAGDFDVLRDTFTTRSGREVALELYVDRGNLDRAPWAMTS---LKNSMKWDEERFG 242

  Fly   304 VPFALPKLDQAGIPDFSAGAMENWGLATYREQYMWWNKQNSTINLKTNIANIIGHEYAHMWFGDL 368
            :.:.|.......:..|:.|||||.||..:..:|:......:|.....:|..:|||||.|.|.|:.
E. coli   243 LEYDLDIYMIVAVDFFNMGAMENKGLNIFNSKYVLARTDTATDKDYLDIERVIGHEYFHNWTGNR 307

  Fly   369 VSIKWWTYLWLKEGFATLFSYE-SNDIAFPLWDTYQIFHVNDYNSALLNDALASAVPMTHYVQTP 432
            |:.:.|..|.||||.......| |:|:.     :..:..:|:..:.........|.||.|.::..
E. coli   308 VTCRDWFQLSLKEGLTVFRDQEFSSDLG-----SRAVNRINNVRTMRGLQFAEDASPMAHPIRPD 367

  Fly   433 S--EISNRYNTFSYAKPASVLYMFKNAWTDKVFRTGLNKYLTKN--QYTSCDEWDLFASFQESAD 493
            .  |::|.|....|.|.|.|:.|......::.|:.|:..|..::  ...:||:   |....|.|
E. coli   368 MVIEMNNFYTLTVYEKGAEVIRMIHTLLGEENFQKGMQLYFERHDGSAATCDD---FVQAMEDA- 428

  Fly   494 ELGFTLPASVD-DIFSSWSHQAGYPLLTVTRNYNAG----TITITQKRYVANKTDTNSATWYVPL 553
                   ::|| ..|..|..|:|.|::||..:||..    |:||:| |..|..........::|
E. coli   429 -------SNVDLSHFRRWYSQSGTPIVTVKDDYNPETEQYTLTISQ-RTPATPDQAEKQPLHIP- 484

  Fly   554 NFATANKYDYRDTSATHYLLNVTETVISDVEASSDDWIIVNIQNSGYYRTLYDTQNYGLITAALK 618
             ||                          :|...::..::.:|..|
E. coli   485 -FA--------------------------IELYDNEGKVIPLQKGG------------------- 503

  Fly   619 SQPWRFHPRN--------RAQLLYDTYIFVSTDRL----SHSILLELLGYLTNEQQ--------- 662
                  ||.|        ....::|...|.....|    |..:.||   |..::||
E. coli   504 ------HPVNSVLNVTQAEQTFVFDNVYFQPVPALLCEFSAPVKLE---YKWSDQQLTFLMRHAR 559

  Fly   663 --YAPWSTANTILTVY-----DRYLRGD---------DSYYNFQDFVKRLIDP------------ 699
              ::.|..|.::|..|     .|:.:|.         |::...  .:...|||
E. coli   560 NDFSRWDAAQSLLATYIKLNVARHQQGQPLSLPVHVADAFRAV--LLDEKIDPALAAEILTLPSV 622

  Fly   700 --------IFDKIGVNEIPGEHYLNNYLRIVLV-SLACQVGSDDCYNQSANKLSEY------LYN 749
                    |.|.|.:.|:          |..|. :||.::..:.....:||..|||      :..
E. coli   623 NEMAELFDIIDPIAIAEV----------REALTRTLATELADELLAIYNANYQSEYRVEHEDIAK 677

  Fly   750 GTAIEATLKTQAYCAGLRSTTNEIYSRVQSDLLSSSDSTDRSLFISS-----LGCSGSTSQLLD- 808
            .|...|.|:..|:     ..|:.....|......:::.||....:|:     |.|..:..|..|
E. coli   678 RTLRNACLRFLAF-----GETHLADVLVSKQFHEANNMTDALAALSAAVAAQLPCRDALMQEYDD 737

  Fly   809 -------------FLRLS------LDTNNSLSYSERTSLLNSAYSRSEIGLTAS---LEFLESNW 851
                         .|:.:      |:|...|......::.|....||.||..|.   ..|...:.
E. coli   738 KWHQNGLVMDKWFILQATSPAANVLETVRGLLQHRSFTMSNPNRIRSLIGAFAGSNPAAFHAEDG 802

  Fly   852 EAYANLSDSAKPLDAALRGIATYVV-------------SEKQKTRLNALVDVVEADGPSY 898
            ..|..|.:....|::....:|:.::             .||.:..|..|..:....|..|
E. coli   803 SGYLFLVEMLTDLNSRNPQVASRLIEPLIRLKRYDAKRQEKMRAALEQLKGLENLSGDLY 862

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31343	NP_732652.1	Peptidase_M1	57..446	CDD:279741	73/274 (27%)
		M1_APN_2	65..517	CDD:189008	91/348 (26%)
		ERAP1_C	591..886	CDD:288671	68/399 (17%)
pepN	NP_415452.1	pepN	1..870	CDD:237585	177/840 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	98	1.000	Domainoid score	I364
eggNOG	1	0.900	-	-		E1_COG0308
Hieranoid	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X67
SwiftOrtho	0	0.000	Not matched by this tool.
	5	4.810