DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31343 and AAP1

DIOPT Version :9

Sequence 1:	NP_732652.1	Gene:	CG31343 / 326133	FlyBaseID:	FBgn0051343	Length:	961	Species:	Drosophila melanogaster
Sequence 2:	NP_011913.1	Gene:	AAP1 / 856443	SGDID:	S000001089	Length:	856	Species:	Saccharomyces cerevisiae

Alignment Length:	905	Identity:	249/905 - (27%)
Similarity:	410/905 - (45%)	Gaps:	90/905 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    58 LPNTTEPESYNVELWTNVHNGDTEFNGTVNIDIRVLNETSN-ITLHYRQTSNFEATIISRDVATP 121
            |||...|..|::.|..|..  ...|.|::.||:::.:.:.| :.::|     .|....|..:...
Yeast     6 LPNNVTPLHYDITLEPNFR--AFTFEGSLKIDLQINDHSINSVQINY-----LEIDFHSARIEGV 63

  Fly   122 TAIPLTVTPELQREFLVLTQTTAGEAFGANTNWTITINYTGIHRSDMGGFYISSYTDD-DGEQHF 185
            .||.:......|:..||....|. |..|.:..  :.|.::||....|.|||.:.|||. .||..:
Yeast    64 NAIEVNKNENQQKATLVFPNGTF-ENLGPSAK--LEIIFSGILNDQMAGFYRAKYTDKVTGETKY 125

  Fly   186 LATTQFESTNARHAFPCYDEPARRANFTITIHHDPSYTAISNMPVNTAATSSG--VTAFQTTPKM 248
            :||||.|:|:||.||||:|||..:|.|.:|:..:...|.:|||.|.......|  .|.|.|||||
Yeast   126 MATTQMEATDARRAFPCFDEPNLKATFAVTLVSESFLTHLSNMDVRNETIKEGKKYTTFNTTPKM 190

  Fly   249 STYLVAFIVSDFESTTGELNGIRQRVFSRKGKQDQQEWALWSGLLVESSLASY---FGVPFALPK 310
            |||||||||:|..........|..||:|..|   .:::..::..|...:|..:   |.:.:.|||
Yeast   191 STYLVAFIVADLRYVESNNFRIPVRVYSTPG---DEKFGQFAANLAARTLRFFEDTFNIEYPLPK 252

  Fly   311 LDQAGIPDFSAGAMENWGLATYREQYMWWNKQNSTINLKTNIANIIGHEYAHMWFGDLVSIKWWT 375
            :|...:.:|||||||||||.|||...:..:.:||:::....:|.:|.||.||.|||:||::.||.
Yeast   253 MDMVAVHEFSAGAMENWGLVTYRVIDLLLDIENSSLDRIQRVAEVIQHELAHQWFGNLVTMDWWE 317

  Fly   376 YLWLKEGFATLFSYESNDIAFPLWDTYQIFHVNDYNSALLNDALASAVPMTHYVQTPSEISNRYN 440
            .|||.|||||..|:.|.:...|.|..::.:..::...||..|:|.|:.|:...|....||:..::
Yeast   318 GLWLNEGFATWMSWYSCNKFQPEWKVWEQYVTDNLQRALNLDSLRSSHPIEVPVNNADEINQIFD 382

  Fly   441 TFSYAKPASVLYMFKNAWTDKVFRTGLNKYLTKNQYTSC---DEWDLFASFQESADELGFTLPAS 502
            ..||:|.:|:|.|......::.|..|:::||.|.:|.:.   |.||..      ||..|    ..
Yeast   383 AISYSKGSSLLRMISKWLGEETFIKGVSQYLNKFKYGNAKTGDLWDAL------ADASG----KD 437

  Fly   503 VDDIFSSWSHQAGYPLLTVTRNYNAGTITITQKRY-----VANKTDTNSATWYVPLNFATA--NK 560
            |..:.:.|:.:.|:|:|:|..:.|  .||:||.||     |..:.||......:.|..:|.  |.
Yeast   438 VCSVMNIWTKRVGFPVLSVKEHKN--KITLTQHRYLSTGDVKEEEDTTIYPILLALKDSTGIDNT 500

  Fly   561 YDYRDTSATHYLLNVTETVISDVEASSDDWIIVNIQNSGYYRTLYDTQNYGLITAALKSQPWRFH 625
            ....:.|||..|.|             :::..:|...||.:.|.|..:.:    |.|..|.....
Yeast   501 LVLNEKSATFELKN-------------EEFFKINGDQSGIFITSYSDERW----AKLSKQANLLS 548

  Fly   626 PRNRAQLLYDTYIFVSTDRLSHSILLELLGYLTNEQQYAPW-STANTILTVYDRYLRGDDSYYNF 689
            ..:|..|:.|.....::...|.:..|.|:....||..:..| ...|::..:...::...:...|.
Yeast   549 VEDRVGLVADAKALSASGYTSTTNFLNLISNWKNEDSFVVWEQIINSLSALKSTWVFEPEDILNA 613

  Fly   690 QDFVKRLIDPIFDK---IGVNEIPGEHYLNNYLRIVLVSLACQVGSDDCYNQSANKLSEYLYNGT 751
            .|  |..:|.:.:|   :|.|....:.:....|::.|.|.||..|::...:.:.....||. ||.
Yeast   614 LD--KFTLDLVLNKLSELGWNIGEDDSFAIQRLKVTLFSAACTSGNEKMQSIAVEMFEEYA-NGN 675

  Fly   752 --AIEATLKTQAYCAGLRSTTNEIYSRVQSDLLSSSDSTDRSLFISSLGCSGSTSQLLDFLRLSL 814
              ||.|..|...:....|......|.::.:...:...|.::.:.:.:|| .....:||:
Yeast   676 KQAIPALFKAVVFNTVARLGGENNYEKIFNIYQNPVSSEEKIIALRALG-RFEDKELLE------ 733

  Fly   815 DTNNSLSYSERTSLLNSAYSRSEIGLTASLEFLESNW----EAYANLSDSAKPLDAALRGIATY- 874
               .:|||....::||..:.....|:....:.:|..|    |.:..::...:|....|.|:.|.
Yeast   734 ---RTLSYLLDGTVLNQDFYIPMQGIRVHKKGIERLWAWMQEHWDEIAKRLQPGSPVLGGVLTLG 795

  Fly   875 ---VVSEKQKTRLNALVDVVEADGPSYINDDLSTTIDSRITSNFAWLEVNRDPVLNWIED 931
               ..|.:...:::|........|   .:..|:..:|: |.|...|:..:|:.|..::.:
Yeast   796 LTNFTSFEALEKISAFYSRKVTKG---FDQTLAQALDT-IRSKAQWVSRDREIVATYLRE 851

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31343	NP_732652.1	Peptidase_M1	57..446	CDD:279741	140/394 (36%)
		M1_APN_2	65..517	CDD:189008	155/461 (34%)
		ERAP1_C	591..886	CDD:288671	60/308 (19%)
AAP1	NP_011913.1	PepN	2..844	CDD:223385	248/896 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0308
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S1087
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X67
TreeFam	0	0.000	Not matched by this tool.
	6	5.860