DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31343 and Erap1

DIOPT Version :9

Sequence 1:	NP_732652.1	Gene:	CG31343 / 326133	FlyBaseID:	FBgn0051343	Length:	961	Species:	Drosophila melanogaster
Sequence 2:	NP_109636.1	Gene:	Erap1 / 80898	MGIID:	1933403	Length:	930	Species:	Mus musculus

Alignment Length:	987	Identity:	281/987 - (28%)
Similarity:	446/987 - (45%)	Gaps:	138/987 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 ILPLSL-----------DDGQLETKGAALFATSRVDDNSAGNYRLPNTTEPESYNVELWTNVHNG 78
            :|||.|           .:..:|:..|     |..|.....|.|||....|..|::.:..|:  .
Mouse     4 LLPLVLTFLSVSSPSWCQNSDIESLKA-----SNGDSFPWNNMRLPEYMTPIHYDLMIHANL--S 61

  Fly    79 DTEFNGTVNIDIRVLNETSNITLHYRQTSNFEATI-------ISRDVATPTAIPLTVTPELQREF 136
            ...|.|...::|.....||.|.:|.......:||:       :|.:       ||.|......|.
Mouse    62 TLTFWGKTEVEIIASRPTSTIIMHSHHLQISKATLRRGAGEMLSEE-------PLKVLEYPAHEQ 119

  Fly   137 LVLTQTTAGEAFGANTNWTITINYTGIHRSDMGGFYISSYTDDDGEQHFLATTQFESTNARHAFP 201
            :.|   .|.:...|.:.:|:.|:|.........|||.|:|...:||...||.||||.|.||.|||
Mouse   120 VAL---LAAQPLLAGSLYTVIIDYAANLSESFHGFYKSTYRTQEGEMRILAATQFEPTAARMAFP 181

  Fly   202 CYDEPARRANFTITIHHDPSYTAISNMP-VNTAATSSGVTA--FQTTPKMSTYLVAFIVSDFEST 263
            |:||||.:|:|:|.|..||.:.|||||| |.:...:.|:..  |..|.||||||||||:|||:|.
Mouse   182 CFDEPALKASFSIKIKRDPRHLAISNMPLVKSVNVAEGLIEDHFDITVKMSTYLVAFIISDFKSV 246

  Fly   264 TG-ELNGIRQRVFSRKGKQDQQEWALWSGLLVESSLASYFGVPFALPKLDQAGIPDFSAGAMENW 327
            :. ..:|::..|::...|.:|.::||.:.:.:......||.:|:.|||.|.|.||||.:||||||
Mouse   247 SKMTKSGVKVSVYAVPDKINQADYALDAAVTLLEFYEDYFNIPYPLPKQDLAAIPDFQSGAMENW 311

  Fly   328 GLATYREQYMWWNKQNSTINLKTNIANIIGHEYAHMWFGDLVSIKWWTYLWLKEGFATLFSYESN 392
            ||.||||..:.::|:.|:.:.|..|..|:.||.||.|||:||:::||..|||.||||....:.|.
Mouse   312 GLTTYRESSLLYDKEKSSASSKLGITMIVSHELAHQWFGNLVTMEWWNDLWLNEGFAKFMEFVSV 376

  Fly   393 DIAFPLWDTYQIFHVNDYNSALLNDALASAVPMTHYVQTPSEISNRYNTFSYAKPASVLYMFKNA 457
            .:..|.......|....:| |:..|||.|:.|::..|:.|::|...::..||.|.|.:|.|.::.
Mouse   377 TVTHPELKVEDYFFGKCFN-AMEVDALNSSHPVSTPVENPAQIREMFDDVSYEKGACILNMLRDY 440

  Fly   458 WTDKVFRTGLNKYLTKNQYTSCDEWDLFASF-----------------------------QESAD 493
            .:...|:.|:.:||.|..|.:....||:.|.                             ||..|
Mouse   441 LSADTFKRGIVQYLQKYSYKNTKNEDLWNSMMHICPTDGTQTMDGFCSRSQHSSSTSHWRQEVVD 505

  Fly   494 ELGFTLPASVDDIFSSWSHQAGYPLLTVT---RNYNAGTITITQKRYV--ANKTDTNSATWYVPL 553
                     |..:.::|:.|.|:||:|:|   ||     :.:.|:.|:  :.:.......|:|||
Mouse   506 ---------VKTMMNTWTLQKGFPLITITVSGRN-----VHMKQEHYMKGSERFPETGYLWHVPL 556

  Fly   554 NFATANKYDYRDTSATHYLLNVTETVISDVEASSDDWIIVNIQNSGYYRTLYDTQNYGLITAALK 618
            .|.|:     :..|...:||.....|:...||.  .||..|:..:|||...|....:..::..||
Mouse   557 TFITS-----KSDSVQRFLLKTKTDVLILPEAV--QWIKFNVGMNGYYIVHYADDGWASLSGLLK 614

  Fly   619 SQPWRFHPRNRAQLLYDTYIFVSTDRLSHSILLELLGYLTNEQQYAP-WSTANTILTVYDRYLRG 682
            .........:||.|:.:.:..||.::||....|:|..||.||.:..| :...|.::.:|....:.
Mouse   615 EAHTTISSNDRASLINNAFQLVSIEKLSIEKALDLTLYLKNETEIMPIFQALNELIPMYKLMEKR 679

  Fly   683 D--DSYYNFQDFVKRLIDPIFDKI------GVNEIPGEHYLNNYLRIVLVSLACQVGSDDCYNQS 739
            |  :....|:||:.:|:..:.||.      .|:|        ..||..|:.|||......|..::
Mouse   680 DMIEVETQFKDFLLKLLKDLIDKQTWTDEGSVSE--------RMLRSQLLLLACVRNYQPCVQRA 736

  Fly   740 ANKLSEY-LYNGT---AIEATLKTQAYCAGLRSTT--NEIYSRVQSDLLSSSDSTDRSLFISSLG 798
            .....|: ..||.   .|:.||  ..:..|.::|.  :.:||:.||.|    .||::|....||
Mouse   737 ERYFREWKSSNGNMSIPIDVTL--AVFAVGAQNTEGWDFLYSKYQSSL----SSTEKSQIEFSL- 794

  Fly   799 CSGSTSQLLDFLRLSLDTNNSLSYSERTSLLNSAYSRSEIGLTASLEFLESNWEAYANLSDSAKP 863
            |:....:.|.:| |.......:..::....:.:...|:.:|...:.:||..||      :...:.
Mouse   795 CTSKDPEKLQWL-LDQSFKGEIIKTQEFPHILTLIGRNPVGYPLAWKFLRENW------NKLVQK 852

  Fly   864 LDAALRGIATYVVSEKQKTRLNALVDVVEADGPSYINDD-----LSTTIDSRITSNFAWLEVNRD 923
            .:.....||..|:....:....|.::.|:....|...:.     :..||:: |..|..|::.|.|
Mouse   853 FELGSSSIAHMVMGTTDQFSTRARLEEVKGFFSSLKENGSQLRCVQQTIET-IEENIRWMDKNFD 916

  Fly   924 PVLNWIEDSLKE 935
            .:..|::....|
Mouse   917 KIRLWLQKEKPE 928

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31343	NP_732652.1	Peptidase_M1	57..446	CDD:279741	148/399 (37%)
		M1_APN_2	65..517	CDD:189008	164/491 (33%)
		ERAP1_C	591..886	CDD:288671	71/309 (23%)
Erap1	NP_109636.1	M1_APN-Q_like	50..515	CDD:341064	162/486 (33%)
		Substrate binding. /evidence=ECO:0000250	306..310		3/3 (100%)
		ERAP1_C	586..905	CDD:403137	77/341 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167845846
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0308
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X67
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.850