DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31343 and Erap1

DIOPT Version :9

Sequence 1:	NP_732652.1	Gene:	CG31343 / 326133	FlyBaseID:	FBgn0051343	Length:	961	Species:	Drosophila melanogaster
Sequence 2:	XP_006231762.1	Gene:	Erap1 / 80897	RGDID:	708542	Length:	954	Species:	Rattus norvegicus

Alignment Length:	969	Identity:	280/969 - (28%)
Similarity:	441/969 - (45%)	Gaps:	144/969 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    55 NYRLPNTTEPESYNVELWTNVHNGDTEFNGTVNIDIRVLNETSNITLHYRQTSNFEATIISRDVA 119
            |.|||....|..|::.:..|:  ....|.|...::|.|...||.|.:|..|....:||:  |..|
  Rat    40 NMRLPEYITPIHYDLMIHANL--STLTFWGKTEVEITVSQPTSTIIMHSHQLQISKATL--RRGA 100

  Fly   120 TPTAIPLTVTPELQREFLVLTQTTAGEAFG--------ANTNWTITINYTGIHRSDMGGFYISSY 176
            .      .:.||   |.|.|.:.:|.|...        |.:.:|:.|.|......:..|||.|:|
  Rat   101 E------EMLPE---EPLKLMEYSAHEQVALLTAQPLLAGSVYTVIITYAANLSENFHGFYKSTY 156

  Fly   177 TDDDGEQHFLATTQFESTNARHAFPCYDEPARRANFTITIHHDPSYTAISNMP-VNTAATSSGVT 240
            ...:||:..||.||||.|.||.||||:||||.:|:|:|.|..||.:.|||||| |.:...:.|:.
  Rat   157 RTQEGERRILAATQFEPTAARMAFPCFDEPALKASFSIKIKRDPRHLAISNMPLVKSVTVAEGLI 221

  Fly   241 A--FQTTPKMSTYLVAFIVSDFESTTG-ELNGIRQRVFSRKGKQDQQEWALWSGLLVESSLASYF 302
            .  |..|.||||||||||:|||:|.:. ..:|::..|::...|.:|.::||.:.:.:......||
  Rat   222 EDHFDITVKMSTYLVAFIISDFKSVSKMTKSGVKVSVYAVPDKINQADYALDAAVTLLEFYEDYF 286

  Fly   303 GVPFALPKLDQAGIPDFSAGAMENWGLATYREQYMWWNKQNSTINLKTNIANIIGHEYAHMWFGD 367
            .:|:.|||.|.|.||||.:||||||||.||||..:.::|:.|:.:.|..|...:.||.||.|||:
  Rat   287 SIPYPLPKQDLAAIPDFQSGAMENWGLTTYRESALLYDKEKSSASSKLGITMTVSHELAHQWFGN 351

  Fly   368 LVSIKWWTYLWLKEGFATLFSYESNDIAFPLWDTYQIFHVNDYN--------------------- 411
            ||:::||..|||.||||....:.|..:..|.....||...|..|
  Rat   352 LVTMEWWNDLWLNEGFAKFMEFVSVTVTHPELKVMQILTANHQNEPEDLSGRAMERTEEEYFFGK 416

  Fly   412 --SALLNDALASAVPMTHYVQTPSEISNRYNTFSYAKPASVLYMFKNAWTDKVFRTGLNKYLTKN 474
              :|:..|||.|:.|::..|:.|::|...::..||.|.|.:|.|.::..:...|:.|:.:||.|.
  Rat   417 CFNAMEVDALNSSHPVSTPVENPAQIREMFDEVSYEKGACILNMLRDYLSADTFKRGIVQYLQKY 481

  Fly   475 QYTSCDEWDLFASF-----------------------------QESADELGFTLPASVDDIFSSW 510
            .|.:....||:.|.                             ||..|         :..:.::|
  Rat   482 SYKNTKNEDLWNSMMHICPTDGTQTMDGFCSRNQHSSSTSHWRQEVID---------IKSMMNTW 537

  Fly   511 SHQAGYPLLTVT-RNYNAGTITITQKRYVANK---TDTNSATWYVPLNFATANKYDYRDTSATHY 571
            :.|.|:||:|:| |..|   :.:.|:.|:...   .:|.| .|:|||.|.|:     :..|...:
  Rat   538 TLQKGFPLITITVRGRN---VHLKQEHYMKGSECFPETGS-LWHVPLTFITS-----KSDSVQRF 593

  Fly   572 LLNVTETVISDVEASSDDWIIVNIQNSGYYRTLYDTQNYGLITAALKSQPWRFHPRNRAQLLYDT 636
            ||.....||...||.  :||..|:..:|||...|....:..:...||.........:||.|:.:.
  Rat   594 LLKTKTDVIILPEAV--EWIKFNVGMNGYYIVHYGDDGWASLNGLLKEAHTTISSNDRASLINNA 656

  Fly   637 YIFVSTDRLSHSILLELLGYLTNEQQYAP-WSTANTILTVYDRYLRGD--DSYYNFQDFVKRLID 698
            :..||..:||....|:|:.||.||.:..| :...|.::.:|....:.|  :....|:||:.||:.
  Rat   657 FQLVSIGKLSIEKALDLILYLKNETEIMPIFQGLNELIPMYKLMEKRDMVEVETQFKDFLLRLLK 721

  Fly   699 PIF------DKIGVNEIPGEHYLNNYLRIVLVSLACQVGSDDCYNQSANKLSEY-LYNGT---AI 753
            .:.      |:..|:|        ..||..|:.|||......|..::.....|: ..||.   .|
  Rat   722 DLINKQTWTDEGSVSE--------RMLRSQLLLLACVHRYQLCVQRAERYFREWKASNGNMSLPI 778

  Fly   754 EATLKTQAYCAGLRSTT--NEIYSRVQSDLLSSSDSTDRSLFISSLGCSGSTSQLLDFLRLSLDT 816
            :.||  ..:..|.::|.  :.:||:.||.|    .||::|....|| |.....:.|.:| |....
  Rat   779 DVTL--AVFAVGAQNTEGWDFLYSKYQSSL----SSTEKSQIEFSL-CISQDPEKLQWL-LDQSF 835

  Fly   817 NNSLSYSERTSLLNSAYSRSEIGLTASLEFLESNWEAYANLSDSAKPLDAALRGIATYVVSEKQK 881
            ...:..::....:.:...|:.:|...:.:||:.||      :...:..:.....||..|:....:
  Rat   836 KGEIIKTQEFPHILTLIGRNPVGYPLAWKFLKENW------NKIVQKFELGSSSIAHMVMGTTNQ 894

  Fly   882 TRLNALVDVVEADGPSYINDD-----LSTTIDSRITSNFAWLEVNRDPVLNWIEDSLKE 935
            ....|.::.|:....|...:.     :..||:: |..|..|::.|.|.:..|::...:|
  Rat   895 FSTRARLEEVKGFFSSLKKNGSQLRCVQQTIET-IEENIRWMDKNFDKIRLWLQKERQE 952

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31343	NP_732652.1	Peptidase_M1	57..446	CDD:279741	153/423 (36%)
		M1_APN_2	65..517	CDD:189008	168/515 (33%)
		ERAP1_C	591..886	CDD:288671	71/309 (23%)
Erap1	XP_006231762.1	Peptidase_M1	42..454	CDD:279741	153/424 (36%)
		M1_APN_2	50..544	CDD:189008	168/515 (33%)
		ERAP1_C	611..927	CDD:288671	76/337 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166349265
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0308
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X67
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.850