DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31343 and Lvrn

DIOPT Version :9

Sequence 1:	NP_732652.1	Gene:	CG31343 / 326133	FlyBaseID:	FBgn0051343	Length:	961	Species:	Drosophila melanogaster
Sequence 2:	NP_083284.1	Gene:	Lvrn / 74574	MGIID:	1921824	Length:	991	Species:	Mus musculus

Alignment Length:	1011	Identity:	266/1011 - (26%)
Similarity:	456/1011 - (45%)	Gaps:	137/1011 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 LNSFSLILLLAVCSLQARLILPLSLDDGQLETKGAALF------------------ATSRVDDNS 52
            |.:..|::|:|:.||..........:.|....|..:|:                  .||:.....
Mouse    22 LTAVLLLVLVALASLYGSCAHVQPSEQGNSRVKNTSLWPPGGQEWALPTPAQEPTVGTSQDLGPP 86

  Fly    53 AG---NYRLPNTTEPESYNVELW-----TNVHNGDTEFNGTVNIDIRVLNETSNITLH-----YR 104
            :|   :.|||....|..|::|||     ..:...:..|.|.|||.:|....:|.:.||     |:
Mouse    87 SGPWDHLRLPPWLVPLHYDLELWPWLQPDKLSPPNLTFTGRVNITVRCTVASSRLLLHSFLLNYK 151

  Fly   105 QTSNFEATIISRDVATPTAIPLTV-----TPELQREFLVLTQTTAGEAFGANTNWTITINYTG-I 163
            |...:..  :::|....|...:.|     .|::|  |:||   ..|::....:.:.::.:::| :
Mouse   152 QVEVWGP--LAQDTRNATVGRVQVEKVWFAPDMQ--FVVL---DLGQSLEPGSRYELSFHFSGQV 209

  Fly   164 HRSDMGGFYISSYTDDDGEQHFLATTQFESTNARHAFPCYDEPARRANFTITIHHDPSYTAISNM 228
            .:..:.|.:::.|.|:| |...|..||.|.|.|||.|||:||||.:|.|.||:.|.|.|.|:|||
Mouse   210 LQVGLEGLFLNLYHDED-ELRALVATQMEPTFARHVFPCFDEPALKATFNITVIHHPGYAALSNM 273

  Fly   229 P-------VNTAATSSGVTAFQTTPKMSTYLVAFIVSDFESTTGELNGIRQRVFSRKGKQDQQEW 286
            |       ::...:...||.|.|||:|.|||||.:|.|.:..:....|...||::||..
Mouse   274 PQLGQSERIDVNGSRWTVTTFHTTPRMPTYLVALVVCDLDHISRTERGKEIRVWARKDD------ 332

  Fly   287 ALWSGLL---------VESSLASYFGVPFALPKLDQAGIPDFSAGAMENWGLATYREQYMWWNKQ 342
             :.||.|         :.|.|...|.:.:.|||.|...:|.|::||||||||..:.|..:....:
Mouse   333 -IASGYLDFAANITGPIFSFLEDLFNISYRLPKTDIVALPIFASGAMENWGLLIFDESSLLLEPE 396

  Fly   343 NSTINLKTNIANIIGHEYAHMWFGDLVSIKWWTYLWLKEGFATLFSYESNDIAFPLWDTYQIFH- 406
            :.....:..|.:||.||..|.|||:||::.||..:||.||||:.|..|..:..:|......||.
Mouse   397 DELTEKRAMILSIIAHEVGHQWFGNLVTMSWWNNIWLNEGFASYFELELTNYFYPKVPMNMIFFF 461

  Fly   407 -----VNDYNSALLNDALASAVPMTHYVQTPSEISNRYNTFSYAKPASVLYMFKNAWTDKVFRTG 466
                 :...:.||.:.|:::||  .::.:| |||:..::.::|.|.|.:.:|..:..:..:|...
Mouse   462 TVLHGILGEDHALESRAVSTAV--ENFTET-SEINRLFDLYTYKKGACMAWMLASFLSPHLFINA 523

  Fly   467 LNKYLTKNQYTSCDEWDLFASFQESADELGFT-LPASVDDIFSSWSHQAGYPLLTVTRNYNAGTI 530
            |..||....|::.::.||:...|.:..|...| |||:|..|..||:|:.|:|::||    |..|.
Mouse   524 LKSYLETFSYSNAEQDDLWRHIQMAIGEQNVTHLPATVKGIMDSWTHRGGFPIITV----NVSTG 584

  Fly   531 TITQKRYVANKTD-----TNSATWYVPLNFATANKYD----YRDTSATHYLLNVTETVISDVEAS 586
            .:.|:.:..:|.:     ::::||.||: |...|...    :.|.|...:    ....:||   |
Mouse   585 VVKQEPFYLDKVENQTLLSHNSTWIVPI-FWMKNGIPQPLVWLDKSNMMF----PGMKLSD---S 641

  Fly   587 SDDWIIVNIQNSGYYRTLYDTQNYGLITAALKSQPWRFHPRNRAQLLYDTYIFVSTDRLSHSILL 651
            ..||:|:|...:||||..||...:..::..|:..|......||.||:.|.:.....:.:.....|
Mouse   642 DSDWVILNFNVTGYYRVNYDELGWKKLSEQLEKDPKAIPVINRLQLVSDAFALTKNNYIEIETAL 706

  Fly   652 ELLGYLTNEQQYAPWSTANTILTVYDRYLRGDDSYYNFQDFVKRLIDPIFDKI--GVNEIPGEHY 714
            :|..|:..|.:...|  ...:|.:.:|.:..|.:.|.....:|:.:...|:.|  ..:.|..|:.
Mouse   707 DLTKYIAEEDEILVW--FEVLLNLINREVIYDVNNYALYPLLKKYLLKRFNSIWNTYSAIIRENV 769

  Fly   715 L---NNYLRIV----LVSLACQVGSDDCYNQSANKLSEY-LYNGTAIEATLKTQAYCAGLRSTTN 771
            .   :|||.:.    :...||.:|.:||...|.....:: .:..|||...::....|:.:...::
Mouse   770 ASLQDNYLSLFSLERIFETACWLGLEDCLQLSRELFKKWTAHPETAIPPQIENAVLCSAVALGSD 834

  Fly   772 EIYSRVQSDLLSSSDSTD---RSLFISSLGCSGSTSQLLDFLRLSLDTNNSLSYSERTSLLNSAY 833
            :.:..:.:..:::::..|   |...:.::.||.....|..|:..:: |..|.::||...::  ..
Mouse   835 KDWDFLFNLYINTTEEEDESRRRRLVHAMSCSKDPWILNRFMEYAI-TAVSSNFSETNIIV--VV 896

  Fly   834 SRSEIGLTASLEFLESNW----EAYANLSDSAKPLDAALRGIATYVVSEKQKTRLNALVD----- 889
            :.||:|...:.:||..||    |.|     ....|||.:..:...|.:::|.|.|.....
Mouse   897 ATSEVGRYIAKDFLMDNWVAVTERY-----GMDWLDALVPVLGRTVSTDQQVTELQHFFSTVLEE 956

  Fly   890 ----VVEADGPSYINDDLSTTIDSRITSNFAWLEVN 921
                ||:|...:....:|..  ..||.....||..|
Mouse   957 HQRVVVQAKLQAMKTKNLQN--KKRIARVVEWLRKN 990

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31343	NP_732652.1	Peptidase_M1	57..446	CDD:279741	135/426 (32%)
		M1_APN_2	65..517	CDD:189008	153/490 (31%)
		ERAP1_C	591..886	CDD:288671	68/311 (22%)
Lvrn	NP_083284.1	Peptidase_M1	94..504	CDD:279741	135/427 (32%)
		M1_APN_2	102..575	CDD:189008	153/490 (31%)
		Substrate binding. /evidence=ECO:0000250	376..380		3/3 (100%)
		ERAP1_C	646..964	CDD:288671	70/327 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167845869
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0308
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.750