DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31343 and Aopep

DIOPT Version :9

Sequence 1:	NP_732652.1	Gene:	CG31343 / 326133	FlyBaseID:	FBgn0051343	Length:	961	Species:	Drosophila melanogaster
Sequence 2:	NP_001276853.1	Gene:	Aopep / 72061	MGIID:	1919311	Length:	823	Species:	Mus musculus

Alignment Length:	538	Identity:	108/538 - (20%)
Similarity:	180/538 - (33%)	Gaps:	174/538 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   117 DVATPTAIP----------LTVTP-----ELQREFLVLTQTT----------------AGEAFGA 150
            |||   |:|          |..||     |:.|:.:.|....                .||....
Mouse   160 DVA---AVPGLEKFTKAPKLLATPEKLRCEIVRDLVALPADAWREQLDCYTRCSQAPGCGELLID 221

  Fly   151 NTNWTITINYTGI-------------HRSDMGGFYISSYTDDDGEQHFLATTQFESTNARHAFPC 202
            :.||::.|..||.             :::...|..::..||.:|..  ...|.....|.|..|||
Mouse   222 SDNWSLRIRKTGTSTPADFPRAIRIWYKTKPEGQSVAWTTDQNGRP--CVYTMGSPINNRALFPC 284

  Fly   203 YDEPARRANFTITIHHDPSYTAISN------------------------MPVNTAATSSGVTAFQ 243
            .:.|...:.:..|:....|:..:.:                        ||.:|.|.:.|... :
Mouse   285 QEPPVAMSTWQATVRAAASFVVLMSGENSAKPTPLREGYMSWHYYVTMPMPASTFAIAVGCWT-E 348

  Fly   244 TTPK-------MSTYLVAFIVSD----FESTTGEL--------------NGIRQRVFSRKGKQDQ 283
            ..||       |:.:.:....|:    :::|...:              :.|..|||:....:..
Mouse   349 MKPKASPPDDLMTEHSLPLSPSEADLRYDNTCNHMEYPCRFQSASAASQDIIPYRVFAPVCLEGA 413

  Fly   284 -QEWALWSGLLVESSLASYFGV----PFALPKLDQAGIPDFSAGAMENWGLATYREQYMWWNKQN 343
             ||..||   |:.|.|::...|    ||:  :||...:|.    ...:.|:|:....::    ..
Mouse   414 CQEALLW---LIPSCLSAAHSVLGTHPFS--RLDILIVPT----NFPSLGMASPHIIFL----SQ 465

  Fly   344 STINLKTNIANIIG----HEYAHMWFGDLVSIKWWTYLWLKEGFAT----LFSYESNDI------ 394
            ||:   |..:::.|    ||.||.|||..:..:.||..||.|||||    :|..|:..:
Mouse   466 STL---TGTSHLCGTRLCHEIAHSWFGLAIGARDWTEEWLSEGFATHLEDIFWAEAQQLPPHEAL 527

  Fly   395 ------AFPLW-----------DTYQIFHVNDYNSALLNDALASAV-----PMTHYVQTPSEISN 437
                  |...|           :..|:...|...:..::.:.||.|     |...::|.
Mouse   528 EQQELRACLRWHRLQDELRNSPEGMQVLRPNKEETGHVSASGASVVKHGLNPEKGFMQV------ 586

  Fly   438 RYNTFSYAKPASVLYMFKNAWTDKVFRTGLNKYLTKNQYTSCDEWDLFASFQESADE---LGFTL 499
                 .|.|...:|........:|::...|.|::...........|......|:..|   ||.
Mouse   587 -----HYLKGYFLLRFLTRTLGEKIYFPFLRKFVHLFHGQLILSQDFLQMLLENIPENKRLGL-- 644

  Fly   500 PASVDDIFSSWSHQAGYP 517
              ||::|...|...:|.|
Mouse   645 --SVENIVRDWLECSGIP 660

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31343	NP_732652.1	Peptidase_M1	57..446	CDD:279741	92/462 (20%)
		M1_APN_2	65..517	CDD:189008	107/536 (20%)
		ERAP1_C	591..886	CDD:288671
Aopep	NP_001276853.1	GluZincin	186..634	CDD:301352	90/477 (19%)
		Leuk-A4-hydro_C	680..821	CDD:286244
		Nucleolar localization signal. /evidence=ECO:0000269\|PubMed:17803194	693..703
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167845880
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0308
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.830