DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31343 and Enpep

DIOPT Version :9

Sequence 1:	NP_732652.1	Gene:	CG31343 / 326133	FlyBaseID:	FBgn0051343	Length:	961	Species:	Drosophila melanogaster
Sequence 2:	NP_071587.2	Gene:	Enpep / 64017	RGDID:	621228	Length:	945	Species:	Rattus norvegicus

Alignment Length:	953	Identity:	250/953 - (26%)
Similarity:	437/953 - (45%)	Gaps:	159/953 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    49 DDNSA--GNYRLPNTTEPESYNVELWTNVHNGDTEFNGTVNIDIRVLNETSNITLHYRQTSNFEA 111
            ||.|.  .|:|||:..:|..|::|:  .|...:..:.|.|:|.:.:..:|.::.||.|:|.
  Rat    74 DDESGEWKNFRLPDFIQPVHYDLEV--KVLMEEDRYTGIVSISVNLSKDTRDLWLHIRETR---- 132

  Fly   112 TIISRDVATPTAIPLTVTPELQR-----------------EFLVLTQTTAGEAFGANTNWTITIN 159
                          :|..|||:|                 |::|:.......|...::.:.:||.
  Rat   133 --------------ITKLPELRRPSGEQVPIRRCFEYKKQEYVVIQAEEDLAATSGDSVYRLTIE 183

  Fly   160 YTGIHRSDMGGFYISSYTDDDGEQHFLATTQFESTNARHAFPCYDEPARRANFTITIHHDPSYTA 224
            :.|.....:.|||.::|| :||:...:|.|..|.|:||.:|||:|||.::|.:.|::.|...|:|
  Rat   184 FEGWLNGSLVGFYRTTYT-EDGQTKSIAATDHEPTDARKSFPCFDEPNKKATYNISLIHPKEYSA 247

  Fly   225 ISNMPVNTAATSSG---VTAFQTTPKMSTYLVAFIVSDFESTTGELNGIRQRVFSRKGK------ 280
            :|||||....|...   .|.|..:..||||||.|.|..|.|.        ||. ||.||
  Rat   248 LSNMPVEKEETLDNDWKKTTFMKSVPMSTYLVCFAVHQFTSI--------QRT-SRSGKPLTVYV 303

  Fly   281 -QDQQEWALWSGLLVES---SLASYFGVPFALPKLDQAGIPDFSAGAMENWGLATYREQYMWWNK 341
             .:|::.|.::..:.::   ....||.:.::|||||:..||||..||||||||.||||..:.::.
  Rat   304 QPNQKQTAEYAANITKAVFDFFEDYFAMEYSLPKLDKIAIPDFGTGAMENWGLVTYRETNLLYDP 368

  Fly   342 QNSTINLKTNIANIIGHEYAHMWFGDLVSIKWWTYLWLKEGFATLFSYESNDIAFPLWDTYQIFH 406
            ..|..:.:..:|:::.||..|.|||::|::.||..|||.||||:.|.:...:.|...|.......
  Rat   369 LLSASSNQQRVASVVAHELVHQWFGNIVTMDWWDDLWLNEGFASFFEFLGVNHAEADWQMLSQVL 433

  Fly   407 VNDYNSALLNDALASAVPMTHYVQTPSEISNRYNTFSYAKPASVLYMFKNAWTDKVFRTGLNKYL 471
            :.|......:|:|.|:.|:...|.||:||::.::..||:|.||:|.|.::..|.:.|:.|...||
  Rat   434 LEDVLPVQEDDSLMSSHPVVVTVSTPAEITSVFDGISYSKGASILRMLQDWITPEKFQKGCQIYL 498

  Fly   472 T----KNQYTSCDEWDLFASFQESADELGFTLPASVDDIFSSWSHQAGYPLLTVTRNYNAGTITI 532
            .    ||..|| |.||   |.::::::       .|.::..:|:.|.|||::||:...|     :
  Rat   499 ENFKFKNAKTS-DFWD---SLEKASNQ-------PVKEVMDTWTSQMGYPVVTVSGKQN-----V 547

  Fly   533 TQKR----YVANKTDTNSA---TWYVPLNFATANKYDYRDTSATHYLLNVTETVISDVEASSDDW 590
            ||||    |.|:.:...||   ||.:|:.: |.|    .:::.|.|..:..|.:..:...|.|.:
  Rat   548 TQKRFLLDYKADPSQPPSALGYTWNIPIKW-TEN----GNSNITVYYRSNREGITLNANLSGDGF 607

  Fly   591 IIVNIQNSGYYRTLYDTQNYGLITAALKSQPWRFHPRNRAQLLYDTYIFVSTDRLSHSILLELLG 655
            :.:|..:.|:||..|:.:.:..|...|.|....|...:|:..:.|.:.......|.:...|.|..
  Rat   608 LKINPDHIGFYRVNYEAETWDWIAETLSSNHMNFSSADRSSFIDDAFALARAQLLDYEKALNLTR 672

  Fly   656 YLTNEQQYAPW----STANTILTVYDRYLRGDDS--YYNFQDFVKRLIDPIFDKIGVNEIPGEHY 714
            |||:|:.:.||    |..:.|:::::     ||.  |...:.:.:..:.||.|.:|..: .|.|
  Rat   673 YLTSEKDFLPWERVISAVSYIISMFE-----DDRELYPLIETYFRSQVKPIADSLGWQD-TGSH- 730

  Fly   715 LNNYLRIVLVSLACQVGSDDCYNQSANKLSEYLYNGTAIEATLKTQAYCAGLRSTTNEI---YSR 776
            :...||..::..||::|:.:....::.....:|....:|...|:...|..|::::.||.   |:.
  Rat   731 ITKLLRASVLGFACKMGAGEALGNASQLFEAWLKGNESIPVNLRLLVYRYGMQNSGNEAAWNYTL 795

  Fly   777 VQSDLLSSSDSTDRSLFISSLGCSGSTSQLLDFLRLSLDTNNSLSYSERTSLLNSAYSRSEIGLT 841
            .|....|.:...::.|:  .|......:.|..:|.:..|.|...:....|.:...:|  :..|.:
  Rat   796 EQYQKTSLAQEKEKLLY--GLASVKDVTLLARYLEMLKDPNIIKTQDVFTVIRYISY--NSYGKS 856

  Fly   842 ASLEFLESNWEAYANLSDSAKPLDAALRGIATYVVSEKQKTRLNALVDVVEADGPSYINDDLS-- 904
            .:..:::.||:...|                .:.::::.   |..:|.:.|.     .|.:|.
  Rat   857 MAWNWIQLNWDYLVN----------------RFTINDRY---LGRIVTIAEP-----FNTELQLW 897

  Fly   905 -------------------TTIDSRITSNFAWLEVNRDPVLNW 928
                               ..:...:.:|..||::||..:..|
  Rat   898 QMQSFFAKYPNAGAGAKPREQVLETVKNNIEWLKLNRKSISEW 940

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31343	NP_732652.1	Peptidase_M1	57..446	CDD:279741	132/418 (32%)
		M1_APN_2	65..517	CDD:189008	150/485 (31%)
		ERAP1_C	591..886	CDD:288671	59/303 (19%)
Enpep	NP_071587.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	45..77		2/2 (100%)
		Peptidase_M1	84..474	CDD:279741	132/419 (32%)
		M1_APN_2	92..537	CDD:189008	150/485 (31%)
		Substrate binding. /evidence=ECO:0000250\|UniProtKB:Q07075	349..353		3/3 (100%)
		ERAP1_C	608..922	CDD:288671	63/348 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X67
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	6.020