Protein Alignment CG31343 and RNPEP

DIOPT Version :9

• Sequence 1: NP_732652.1
• Gene: CG31343 / 326133
• FlyBaseID: FBgn0051343
• Length: 961
• Species: Drosophila melanogaster
• Sequence 2: NP_064601.3
• Gene: RNPEP / 6051
• HGNCID: 10078
• Length: 650
• Species: Homo sapiens
• Alignment Length: 548
• Identity: 121/548 - (22%)
• Similarity: 182/548 - (33%)
• Gaps: 138/548 - (25%)

  Fly    39 GAA---LFATSRVDDNSAGNYRLPNTTEPESYNVELWTNVH-------------NGDTEFNGTVN 87
            |||   |.:...||..||.|:|.          .|| .::|             .|....:||..
Human    11 GAARRPLHSAQAVDVASASNFRA----------FEL-LHLHLDLRAEFGPPGPGAGSRGLSGTAV 64

  Fly    88 IDIRVLNE--TSNITLHYRQTSNFEATIISRD-------VATPTAI------------------P 125
            :|:|.|..  .:.:.|.........|..:.|:       .|.|.:.                  |
Human    65 LDLRCLEPEGAAELRLDSHPCLEVTAAALRRERPGSEEPPAEPVSFYTQPFSHYGQALCVSFPQP 129

  Fly   126 LTVTPELQREFLVLTQTTAGEAFGANTNWTITINYTGIHRSDMGGFYISSYTDDDGEQHFLATTQ 190
            ......||    ||.....||  |....| :....|.                  |::.....||
Human   130 CRAAERLQ----VLLTYRVGE--GPGVCW-LAPEQTA------------------GKKKPFVYTQ 169

  Fly   191 FESTNARHAFPCYDEPARRANFTITIHHDPSYTAISNMPVNT-AATSSGVTAFQTTPKMSTYLVA 254
            .::...|..|||:|.||.:..::..|.....:||:  |..:| .........||....:.:||:|
Human   170 GQAVLNRAFFPCFDTPAVKYKYSALIEVPDGFTAV--MSASTWEKRGPNKFFFQMCQPIPSYLIA 232

  Fly   255 FIVSDFESTTGELNGIRQRVFSRKGKQDQQEWALWSGLLVESSLASYFGV-------------PF 306
            ..:.|..|  .|: |.|.||           ||  ...|::::...|.||             |:
Human   233 LAIGDLVS--AEV-GPRSRV-----------WA--EPCLIDAAKEEYNGVIEEFLATGEKLFGPY 281

  Fly   307 ALPKLDQAGI-PDFSAGAMENWGLATYREQYMWWNKQNSTINLKTNIANIIGHEYAHMWFGDLVS 370
            ...:.|...: |.|..|.|||..|.......:..::         ::|::|.||.:|.|||:||:
Human   282 VWGRYDLLFMPPSFPFGGMENPCLTFVTPCLLAGDR---------SLADVIIHEISHSWFGNLVT 337

  Fly   371 IKWWTYLWLKEGFATLFSYESNDIAFPLWDTYQIFHVNDYNSALLN---DALASAVPMTHY---V 429
            ...|...||.|||........:.|.|..  .|....... ..|||.   |......|:...   :
Human   338 NANWGEFWLNEGFTMYAQRRISTILFGA--AYTCLEAAT-GRALLRQHMDITGEENPLNKLRVKI 399

  Fly   430 QTPSEISNRYNTFSYAKP-ASVLYMFKNAWTDKVFRTGLNKYLTKNQYTSCDEWDLFASFQESAD 493
            :...:..:.||...|.|. ..|.|:.........|.:.|..|:.:.::.|....|....:.|...
Human   400 EPGVDPDDTYNETPYEKGFCFVSYLAHLVGDQDQFDSFLKAYVHEFKFRSILADDFLDFYLEYFP 464

  Fly   494 ELGFTLPASVDDI----FSSWSHQAGYP 517
            ||   ....||.|    |..|.:..|:|
Human   465 EL---KKKRVDIIPGFEFDRWLNTPGWP 489

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG31343	NP_732652.1	Peptidase_M1	57..446	CDD:279741	94/449 (21%)
		M1_APN_2	65..517	CDD:189008	110/517 (21%)
		ERAP1_C	591..886	CDD:288671
RNPEP	NP_064601.3	leuko_A4_hydro	24..634	CDD:274120	116/535 (22%)
		M1_LTA4H	24..484	CDD:189006	114/528 (22%)
		Substrate binding. /evidence=ECO:0000250	298..302		2/3 (67%)
		Leuk-A4-hydro_C	504..644	CDD:286244

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0308
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810