DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31343 and erap1a

DIOPT Version :9

Sequence 1:	NP_732652.1	Gene:	CG31343 / 326133	FlyBaseID:	FBgn0051343	Length:	961	Species:	Drosophila melanogaster
Sequence 2:	XP_009303348.1	Gene:	erap1a / 564068	ZFINID:	ZDB-GENE-091113-7	Length:	933	Species:	Danio rerio

Alignment Length:	1002	Identity:	277/1002 - (27%)
Similarity:	443/1002 - (44%)	Gaps:	150/1002 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 WLLNSFSLILLLAVCSLQA----------RLILPLSLDDGQLETKGAALFATSRVDDNSAGNYRL 58
            :|...|...|:...|:|.|          :.:||...|                       ..||
Zfish     3 FLAKYFHFTLVALFCALFAGNHAMTVNKNKTVLPFPWD-----------------------KMRL 44

  Fly    59 PNTTEPESYNVELWTNVHNGDTEFNGTVNIDIRVLNETSNITLHYRQTSNFEATIISRDVATPTA 123
            |...:|:.|::.:..|:.:  ..|.|.|.|.|.|..:|..|.||            |:::....|
Zfish    45 PEIVKPQHYDLLIHPNLTS--LTFTGEVQIQIEVKQDTRAIILH------------SKNLQVSKA 95

  Fly   124 IPLTVTPELQREFLVLTQTTAGEAFGA-NTNWTITINYTGIH-------RSDMGGFYISSYTDDD 180
            :.|........:.|.:::..|.|.... :..:|.......:|       .....|||...||.:.
Zfish    96 LLLGSRQHHHHQDLQISEFEANEQIALFSEGFTFEKGSHVVHLEFYANLSDSFHGFYKGQYTTNS 160

  Fly   181 GEQHFLATTQFESTNARHAFPCYDEPARRANFTITIHHDPSYTAISNMP-VNTAATSSGV--TAF 242
            ||...||:||||.|:||.||||:||||.:|||||.:..:..:.:||||| :.|...:.|:  ..|
Zfish   161 GEVRMLASTQFEPTHARAAFPCFDEPAFKANFTIRVRRESRHISISNMPKLRTVELADGILEDQF 225

  Fly   243 QTTPKMSTYLVAFIVSDFESTTGE-LNGIRQRVFSRKGKQDQQEWALWSGLLVESSLASYFGVPF 306
            .|..||||||||||:.||.|.:.: .:|:...|::...|..|.|:||.:.:.:......||.:|:
Zfish   226 DTMVKMSTYLVAFIICDFHSISKKSQHGVEISVYTVPEKISQAEYALDTAVTMLDFYDEYFDIPY 290

  Fly   307 ALPKLDQAGIPDFSAGAMENWGLATYREQYMWWNKQNSTINLKTNIANIIGHEYAHMWFGDLVSI 371
            .|||.|.|.||||.:||||||||:||||..:.::.:.|:.:.|..|..:|.||.||.|||:||::
Zfish   291 PLPKHDLAAIPDFQSGAMENWGLSTYRESGLLFDPEKSSSSDKLGITKVIAHELAHQWFGNLVTM 355

  Fly   372 KWWTYLWLKEGFATLFSYESNDIAFPLWDTYQIFHVNDY-----NSALLNDALASAVPMTHYVQT 431
            :||..|||.||||....|.|.:|      |:....||||     .:||..|:|:|:.|::..|:.
Zfish   356 QWWNDLWLNEGFAKFMEYVSVNI------THPELQVNDYFLEKCFTALSVDSLSSSHPVSTPVEN 414

  Fly   432 PSEISNRYNTFSYAKPASVLYMFKNAWTDKVFRTGLNKYLTKNQYTSCDEWDLFASFQE--SADE 494
            |:|||..::..||.|.|.:|.|.::..|.:||:.|:..||.|:.|.:.....|:.|...  ::|.
Zfish   415 PAEISEMFDDVSYRKGACILNMLRDFLTPEVFKYGIINYLKKHSYQNTVNSHLWESLTNICTSDG 479

  Fly   495 L--------GF------TLPAS---------VDDIFSSWSHQAGYPLLTVTRNYNAGTITITQKR 536
            |        ||      ..|||         |..|..:|:.|.|:||:||  ......:|:.|:|
Zfish   480 LDSGRLKLDGFCSKHTAETPASKWFKEDSVDVGAIMDTWTLQEGFPLITV--EVKGQEVTLKQER 542

  Fly   537 YVANKTDTNSAT--WYVPLNFATANKYDYRDTSATHYLLNVTETVISDVEASSDDWIIVNIQNSG 599
            ::.....:||::  |.|||.:.|:.     ..:...:||.....|....|  ..:||..|:...|
Zfish   543 FLKGAESSNSSSFLWQVPLTYITSG-----SNAVQRFLLKTERDVFYLPE--KVEWIKFNVDLRG 600

  Fly   600 YYRTLYDTQNYGLITAALKSQPWRFHPRNRAQLLYDTYIFVSTDRLSHSILLELLGYLTNEQQYA 664
            ||...|::..:..:...|:.....|...:||.|::|.:..||.:::.....|.|..||:.|.:..
Zfish   601 YYIVHYESGGWDCLIKQLRMNHTVFSSNDRASLIHDIFQLVSIEKVPLDKALNLSLYLSKESEIM 665

  Fly   665 PWSTA-NTILTVYDRYLRGD--DSYYNFQDFVKRLIDPIFDK--IGVNEIPGEHYLNNYLRIVLV 724
            |.:.. :.::.:|....:.|  :.....:..:.:|..|:.|:  ...|....|..|.|||.:
Zfish   666 PVTQGFSELVPLYKLMEKRDMQELENQLKSHLVKLFQPLIDRQSWSDNGSVSERMLRNYLLL--- 727

  Fly   725 SLACQVGSDDCYNQSANKLSEY------LYNGTAIEATLKTQAYCAGLRSTTN-----EIYSRVQ 778
             .||......|.:.:.....::      ::..|.:...:    |..|.|:...     |.|.|
Zfish   728 -FACVRRYPSCVSTATQLFHKWKESDGKMWLPTDVSLVV----YTEGARTDDGWDFLLEKYKR-- 785

  Fly   779 SDLLSSSDSTDRSLFISSLGCSGSTSQLLDFLRLSLDTNNSLSYSERTSLLNSAYSRSEIGLTAS 843
                 |...:::.:..::|..|....:|...|..|.: ...:...:..|:|.|. |::..|...:
Zfish   786 -----SVSPSEKWMIKAALSYSPLAHKLQWLLERSSE-GEIMKTQDLPSMLISV-SKNPKGFKLA 843

  Fly   844 LEFLESNWEAYANLSDSAKPLDAALRGIATYVVSEKQKTRLNALVDVVEADGPSYINDDLS--TT 906
            .:||:|||      ....|..|.....|:..||....:.....::|.||....|...|..|  .:
Zfish   844 WDFLKSNW------GKLVKKFDLGSSAISRVVVGVTDQYSTKEMLDEVELFFGSLAQDQGSGLRS 902

  Fly   907 ID---SRITSNFAWLEVNRDPVLNWIE 930
            |.   .:|..|..|::.|...:..|::
Zfish   903 IQQALEKIQQNILWMDRNVPLLKAWLD 929

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31343	NP_732652.1	Peptidase_M1	57..446	CDD:279741	149/405 (37%)
		M1_APN_2	65..517	CDD:189008	171/493 (35%)
		ERAP1_C	591..886	CDD:288671	62/310 (20%)
erap1a	XP_009303348.1	Peptidase_M1	43..430	CDD:279741	149/406 (37%)
		M1_APN_2	52..525	CDD:189008	171/492 (35%)
		ERAP1_C	592..909	CDD:288671	69/339 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170590549
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0308
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X67
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	7	6.850