DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31343 and trhde.2

DIOPT Version :9

Sequence 1:	NP_732652.1	Gene:	CG31343 / 326133	FlyBaseID:	FBgn0051343	Length:	961	Species:	Drosophila melanogaster
Sequence 2:	XP_690889.2	Gene:	trhde.2 / 562409	ZFINID:	ZDB-GENE-070705-89	Length:	994	Species:	Danio rerio

Alignment Length:	947	Identity:	267/947 - (28%)
Similarity:	432/947 - (45%)	Gaps:	134/947 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 LLNSFSLILLLAVCSLQARLILPLSLDDGQLETKGAAL---FATSRVDDNSAGN----------- 55
            |:..|::.:|..:......:.|.:|.:....|:.||..   .:.|:...:..||
Zfish    39 LVLGFAISILTLIIVTAIAITLSVSFERCAAESSGALAANGSSNSKWKQSRDGNISHRDSEDGQQ 103

  Fly    56 ----YRLPNTTEPESYNVELWTNVHNGDTEFNGTVNIDIRVLNETSNITLHYRQTSNFEATIISR 116
                .|||.|..|..|::.|  .||..:..|:|.|||:...:|.|..|.|| ......:..::..
Zfish   104 PWRHLRLPATLRPRHYDLRL--TVHMENFSFSGEVNIEFECVNSTKLIVLH-SDRLELDKVLVFS 165

  Fly   117 DVATPTAIPLTVTPELQREF-----LVLTQTTAGEAFGANTNWTITINYTGIHRSDMGGFYISSY 176
            |.....|:      .:||.|     .|.......|.....| :.|.|.:|.....::.||:.|||
Zfish   166 DSKKAGAM------RIQRRFHYQPKQVYVIALHREMKPLRT-YKINITFTAHIEHELLGFFRSSY 223

  Fly   177 TDDDGEQHFLATTQFESTNARHAFPCYDEPARRANFTITIHHDPSYTAISNMPVN-TAATSSG-- 238
            . .:||:.|||.|||..|:||.||||:|||..:|.|.:::.|:.||.::|||||. |.:...|
Zfish   224 M-LNGERRFLAVTQFSPTHARKAFPCFDEPIYKATFRVSLKHESSYQSLSNMPVEATTSDEDGWV 287

  Fly   239 VTAFQTTPKMSTYLVAFIVSDF---ESTTGELNGIRQRVFSRKGKQDQQEWALWSG-----LLVE 295
            ...|..||:||||.:|:.|.:|   |:...  ||:..|:::|..       |:.||     |.:.
Zfish   288 TNHFSRTPRMSTYYLAWAVCNFTYKEAVAD--NGVLIRLYARPD-------AIQSGSGDYALRIT 343

  Fly   296 SSL----ASYFGVPFALPKLDQAGIPDFSAGAMENWGLATYREQYMWWNKQNSTINLKTNIANII 356
            ..|    ..||.|.::|||||...:|.....|||||||:.:.||.:..:...|:.:.:..:..::
Zfish   344 KRLLQFYQDYFKVKYSLPKLDLLAVPKHPYAAMENWGLSVFVEQKILLDPDVSSFSYQMELTMVV 408

  Fly   357 GHEYAHMWFGDLVSIKWWTYLWLKEGFATLFSYESNDIAFPLWD-TYQIFHVNDYNSALLNDALA 420
            .||..|.||||||:..||..:|||||||..|.|...|..||.|: ..|.|..:..:..:|.|.||
Zfish   409 VHEICHQWFGDLVTPVWWEDVWLKEGFAHYFEYIGTDFLFPKWNMEKQRFLTDVLHEVMLLDGLA 473

  Fly   421 SAVPMTHYVQTPSEISNRYNTFSYAKPASVLYMFKNAWTDKVFRTGLNKYLTKNQYTSCDEWDLF 485
            |:.|::..|...::|...::..:|.|.|:::.|..|.....:|:..||.||..:.|.:....||:
Zfish   474 SSHPISQQVFEATDIDRVFDWIAYKKGAALIRMLANVMGQTLFQRALNDYLMTHMYGNAARDDLW 538

  Fly   486 ASFQESADELGFTLPASVDDIFSSWSHQAGYPLLTVTRNYNA-GTITITQKRYVANKTD------ 543
            ....|:....|..:  ::..:...|:.|.|||::|:::|.:. .:|||:|:.:|.: ||
Zfish   539 NKLSEAMQREGKDI--NITQVMDRWTLQMGYPVVTISKNDSLDNSITISQEHFVYD-TDAKIQNP 600

  Fly   544 ---TNSATWYVPLNFATANKYDYRDTSATHYLLNVTETVISDVEAS---------SDDWIIVNIQ 596
               ..|..|.:||..|..|        |:|.   .|||:|.....|         .:.|::.||.
Zfish   601 ELFNKSFQWQIPLTLAVGN--------ASHI---STETIIWVTNKSEAHRVGHVVGETWLLGNIN 654

  Fly   597 NSGYYRTLYDTQNYGLITAALKSQPWRFHPRNRAQLLYDTYIFVSTDRLSHSILLELLGYLTNEQ 661
            .:||:|..||..|:.|:...|...|......|||.|:.|.:.......|..::.|:::.||:.|.
Zfish   655 QTGYFRVNYDLHNWKLLIQQLTRNPTIISVGNRAGLIDDVFNLARAGYLPQNVPLQMISYLSQET 719

  Fly   662 QYAPWSTANTILTVYDRYLRGDDSYYNFQDFVKRLIDPIFDKIG------VNEIPGEHYLNNYLR 720
            ::.||..|:..|...|:.|.....:..|.|:|.|.::|.:.|:|      ...:....|....|:
Zfish   720 EFLPWHAASRALYQLDKLLDRTLDHSLFSDYVLRQVEPKYHKLGWPATSPDGSLMHSAYQTEELQ 784

  Fly   721 IVLVSLACQVGSDDCYNQSANKLSEYL-YNGTAIEATLKTQAYCAGLRSTTNEIYSRVQSDLLSS 784
            ..::.|||..|:..|:.|:.:.:|::: .|...|...::...||.|:.....:::..:.....||
Zfish   785 REVIMLACSFGNKHCHRQAVSLISDWISSNKNRIPPNVRDIVYCTGVSLMDEDVWEFIWMKFHSS 849

  Fly   785 SDSTDRSLFISSLGCSGSTSQLLDFLRLSLDTN----------------NSLS-------YSERT 826
            :..:::.:.:.:|.||.:...|...|.|||.::                |.|.       :.|:.
Zfish   850 TAVSEKKVLLEALTCSDNIFLLNRLLNLSLTSDLVPDQDVIDVIIHVARNPLGRHLAWRYFREKW 914

  Fly   827 SLLNSAY-------SRSEIGLTASLEFLESNWEAYAN 856
            .:|||.|       |:...|:|   |||  |.||..|
Zfish   915 DILNSRYGEALFMNSKLISGVT---EFL--NTEAELN 946

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31343	NP_732652.1	Peptidase_M1	57..446	CDD:279741	139/409 (34%)
		M1_APN_2	65..517	CDD:189008	151/472 (32%)
		ERAP1_C	591..886	CDD:288671	75/303 (25%)
trhde.2	XP_690889.2	Peptidase_M1	109..500	CDD:279741	139/410 (34%)
		M1_APN_2	118..568	CDD:189008	151/471 (32%)
		ERAP1_C	649..968	CDD:288671	75/303 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170590527
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0308
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11533
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X67
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.940