DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31343 and anpepa

DIOPT Version :9

Sequence 1:	NP_732652.1	Gene:	CG31343 / 326133	FlyBaseID:	FBgn0051343	Length:	961	Species:	Drosophila melanogaster
Sequence 2:	NP_001038326.1	Gene:	anpepa / 558452	ZFINID:	ZDB-GENE-030131-4781	Length:	946	Species:	Danio rerio

Alignment Length:	992	Identity:	260/992 - (26%)
Similarity:	447/992 - (45%)	Gaps:	144/992 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 LLAVCSLQARLILPLSLDDGQLETKGAALFATSRVDDNS-----------------AGNYRLPNT 61
            ::.|||:...:::              |:|...:|.:|.                 ..:.|||::
Zfish    17 VITVCSVGCLVVM--------------AVFFQIQVGNNKPTPPPRPILPTPLPTDLPESLRLPDS 67

  Fly    62 TEPESYNV----ELWTNVHNGDTE----FNGTVNIDIRVLNETSNITLHYRQTSNFEATIIS-RD 117
            ..||||||    .|:..:.|..||    |.|...:.:.....:|.:.||   ..|...|.:. |.
Zfish    68 LIPESYNVFLQPYLYAAITNNYTEQSYLFTGNSTVRVNCTKTSSRVFLH---VHNINVTAVEVRK 129

  Fly   118 VATPTAIPLTVTPELQRE--FLVLTQTTAGEAFGANTNWTITINYTGIHRSDMGGFYISSY---- 176
            ..|...:||......:.|  ||.:....   |...|..:.|...:.|....|:.|||.|.|
Zfish   130 SDTNEKLPLKGYQIFKNETNFLDIHLEV---AIKENGTYDIFTEFEGELLEDLTGFYASRYTGKG 191

  Fly   177 TDDDGEQHFLATTQFESTNARHAFPCYDEPARRANFTITIHHDPSYTAISN-----MPVNTAATS 236
            |||:.|:.||||:..:.|:||..|||:||||.:|.|||||.|.|...|.||     ..:....|.
Zfish   192 TDDEDEERFLATSLLQPTDARTVFPCFDEPAMKAVFTITIIHRPEIRARSNEDGDPRTIQINGTD 256

  Fly   237 SGVTAFQTTPKMSTYLVAFIVSDFESTTGELNGIRQRVFSRKGKQD-----QQEWALWSGLLVES 296
            ...|.|:.|.|||:||:.||:.|..:.:....|.|.::... |:.:     ..::||.:...:.|
Zfish   257 WIRTTFKPTKKMSSYLLGFIIYDTHTFSYVSKGTRTKIHVH-GRSEAIDAGHADYALETTETILS 320

  Fly   297 SLASYFGVPFALPKLDQAGIPDFSAGAMENWGLATYREQYMWWNKQNSTINLKTNIANIIGHEYA 361
            ...:.||:.:.:.|:||..:|||...||||||..:|:|..:.::|:.::...:..:..:|.||.|
Zfish   321 HYENIFGLRYPMSKIDQIALPDFGVRAMENWGFISYQESGLLYDKETASTFDEEQVTTLIAHELA 385

  Fly   362 HMWFGDLVSIKWWTYLWLKEGFATLFSYESNDIAFPLWDTYQIFHVNDYNSALLNDALASAVPMT 426
            |.|||:||::.||..|||||||||..||:..:...  ||...:..:.:..:|...|:|.::.|::
Zfish   386 HQWFGNLVTMSWWNDLWLKEGFATYMSYKGVEAVG--WDLKDLIVLREIQTAFQMDSLNTSHPLS 448

  Fly   427 ---HYVQTPSEISNRYNTFSYAKPASVLYMFKNAWTDKVFRTGLNKYLTKNQYTSC---DEWDLF 485
               :.|||.|:||..::..:|:|.|:||.|......:..|..|:..||:|.|:.:.   |.|:.
Zfish   449 MNAYDVQTSSQISELFDDITYSKGAAVLRMLATRMGENEFMKGVKMYLSKFQFENTVPKDLWEC- 512

  Fly   486 ASFQESADELGFTLPASVDDIFSSWSHQAGYPLLTVTRNYNAGTITITQKRYVANKTDTNSATWY 550
                     |.......||:...:|:.:.|||:||:..:    |...:|::::..|...:.:.|:
Zfish   513 ---------LNMDTHIKVDEFMKTWTEEVGYPVLTIITD----TGDTSQEQFLLKKEGGHDSLWH 564

  Fly   551 VPLNFAT--ANKYDYRDTSATHYLLNVTETVISDVEASSDDWIIVNIQNSGYYRTLYDTQNYGLI 613
            :|:.:.|  |...::     .::..:.....|.|.:...|:|::.||..:|:||..||.:|:..:
Zfish   565 IPIKYMTLKAGVKEF-----PNFFTDKGPDPIPDFKIGKDNWLLANINCTGFYRVNYDEENWNRL 624

  Fly   614 TAALKSQPWRFHPR-NRAQLLYDTYIFVSTDRLSHSILLELLGYLTNEQQYAPWSTANTILTVYD 677
            ||.|:.. .|..|. ||.||:.|.:......||:.:|.|.|..||.|:.:|.||.:|...|..:.
Zfish   625 TAQLQKN-HRIIPLINRGQLIDDAFNLARAHRLNVTIALNLTKYLINDLEYIPWESALKNLDFFT 688

  Fly   678 RYLRGDDSYYNFQDFVKRLIDPI---FDKIGVN-EIPGEHYLNNYLRIVLVSLACQVGSDDCYNQ 738
            ......:.|.....:::.|:.|:   :::..:| .||.|.|.:...::..:::||..|..:|...
Zfish   689 LMFDRSEVYGPIMKYLRNLVTPLYEEYEEYTINGTIPIEKYTDQCNQVNAITVACSNGLPECITM 753

  Fly   739 SANKLSEYLYNGTAIEATLKTQAYCAGLRSTTNEIYSRVQSDLLSSSDSTDRSLFISSLGCSGST 803
            :.:..|:|......|...|:...||:.:.|...:.:..|..:...::.:.::.....:|.|:...
Zfish   754 AKDLFSDYKNGSNPIHPNLRRAVYCSAVASGDEDDWEYVWEEYQKATVAAEKDKLRYALSCTKEI 818

  Fly   804 SQLLDFLRLSL--------DTNNSLSYSERTSLLNSAYSRSEIGLTASLEFLESNW-----EAYA 855
            ..|..:|:.:|        |..:::||          .:::..|...:.:|:..:|     |..|
Zfish   819 WLLNRYLQYTLEPSKIRKMDMVSTISY----------IAQNVAGQPLAWDFIRGHWSYITQEYGA 873

  Fly   856 NLSDSAKPLDAALRGIATYVVSE--KQKTRLNALVDVVEADGPSYINDD-------LSTTIDSRI 911
            .:......||...:..:|.|..|  ||..|             ..|.||       |...|: |.
Zfish   874 GIISLGSLLDVVTKRFSTEVELEELKQLQR-------------EQIQDDKWIAARALEQVIE-RT 924

  Fly   912 TSNFAWLEVNRDPVLNW 928
            .:|..|::.|:..|.:|
Zfish   925 AANIIWVKENKQVVKDW 941

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31343	NP_732652.1	Peptidase_M1	57..446	CDD:279741	137/416 (33%)
		M1_APN_2	65..517	CDD:189008	151/482 (31%)
		ERAP1_C	591..886	CDD:288671	72/314 (23%)
anpepa	NP_001038326.1	Peptidase_M1	63..472	CDD:279741	137/417 (33%)
		M1_APN_2	71..535	CDD:189008	151/482 (31%)
		ERAP1_C	602..923	CDD:288671	77/345 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	105	1.000	Domainoid score	I6573
eggNOG	1	0.900	-	-		E1_COG0308
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X67
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	8	7.920