DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31343 and si:ch211-106j24.1

DIOPT Version :9

Sequence 1:	NP_732652.1	Gene:	CG31343 / 326133	FlyBaseID:	FBgn0051343	Length:	961	Species:	Drosophila melanogaster
Sequence 2:	XP_021327531.1	Gene:	si:ch211-106j24.1 / 555478	ZFINID:	ZDB-GENE-130530-595	Length:	960	Species:	Danio rerio

Alignment Length:	1008	Identity:	291/1008 - (28%)
Similarity:	461/1008 - (45%)	Gaps:	161/1008 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 LLLAVCSLQARLILPLSLDDGQLETKGAALFA---------TSRVDDNSAGNYRLPNTTEPESYN 68
            ::||..:|..  |:.||:...:.::|..|...         |.:..:.....||||:|..|:.||
Zfish    16 MILAAIALVT--IIALSVVYNREKSKNTAKLTNATTSAVPPTPKPSNEPWDKYRLPDTLSPQYYN 78

  Fly    69 VELWTNV---HNGDTEFNGTVNIDIRVLNETSNITLHYRQTSNFEATIISRDVATPTAIPLTVTP 130
            :.||..:   .||...|.|..::....:.:|..|.:|   ::....|:.:...|..|.:.....|
Zfish    79 ITLWPQMVMDANGMYIFTGISDVMFTCVKKTDLILIH---SNKLNLTLFNGRHAKLTGMSGVTAP 140

  Fly   131 -------ELQREFLVLTQTTAGEAFGANTNWTITINYTGIHRSDMGGFYISSYTDDDGEQHFLAT 188
                   :.|.::||:  ...|:.....:.|..| .:||....|:.|||.|.|. :|||:..:|.
Zfish   141 AIKSTWLQTQTQYLVI--QLKGKLNPGKSYWLHT-EFTGELADDLEGFYRSEYM-EDGEKKIIAI 201

  Fly   189 TQFESTNARHAFPCYDEPARRANFTITIHHDPSYTAISN-------------MPVNTAATSSGVT 240
            ||.::|.||.||||:|||..:|.|.|.:.||...||:||             |||..       |
Zfish   202 TQMQATYARKAFPCFDEPGMKAVFNIILIHDRGMTALSNSQEIRTEDVIIDEMPVTR-------T 259

  Fly   241 AFQTTPKMSTYLVAFIVSDFESTTGE-LNGIRQRVFSRKGKQD--QQEWALWSGLLVESSLASYF 302
            .|:.|.:||||||||:||||.....| ..|:..|:::||...|  |.::||.....:.....||:
Zfish   260 TFEPTARMSTYLVAFVVSDFSYINNEDKAGVLVRIWARKKAIDDGQGDYALSITQPILEFFESYY 324

  Fly   303 GVPFALPKLDQAGIPDFSAGAMENWGLATYREQYMWWNKQNSTINLKTNIANIIGHEYAHMWFGD 367
            ...:.|.|.||..:|||::||||||||.||||..:.::.|.|....|..||.::.||.||||||:
Zfish   325 NTSYPLSKSDQVALPDFNSGAMENWGLVTYRETALLYDPQTSANGNKQRIATVVSHELAHMWFGN 389

  Fly   368 LVSIKWWTYLWLKEGFATLFSYESNDIAFPLWDTYQIFHVNDYNSALLNDALASAVPMT---HYV 429
            ||::|||..|||.||||:...|...|.|.|.|:......:.|...|...|:|.|:.|::   ..|
Zfish   390 LVTLKWWNDLWLNEGFASYVEYLGADHAEPTWNIKDQIILYDMQRAFAVDSLTSSHPLSRKEEEV 454

  Fly   430 QTPSEISNRYNTFSYAKPASVLYMFKNAWTDKVFRTGLNKYLTKNQYTSCDEWDLFASFQESADE 494
            .||:|||..::|.||:|.|:||.|.....|:.||..||:.||.:..:.|....||:...|:|.|:
Zfish   455 NTPAEISEMFSTISYSKGAAVLKMLSEFLTEPVFAKGLSNYLKQFAFGSSVHSDLWDHLQKSLDQ 519

  Fly   495 L-GFTLPASVDDIFSSWSHQAGYPLLTV-TRNYNAGTITITQKRY-------VANKTDTNSATWY 550
            . |..||.|:.:|.|.|..|.|:|::|: ||..|     ::||.:       |..|::.| ..|:
Zfish   520 APGMKLPRSIHEIMSRWILQMGFPVITIDTRTGN-----VSQKHFLVEKDAVVERKSEFN-YEWF 578

  Fly   551 VPLNFATANKYDYRD------TSATHYLLNVTETVISDVEASSDDWIIVNIQNSGYYRTLYDTQN 609
            ||:.:  ..|...:|      .||.|          ..::.|..:|::.|.:.|||:|..||..|
Zfish   579 VPIKW--MKKGQVQDQMWLLQKSAIH----------KPMKVSKGEWVLANHKVSGYFRVNYDHGN 631

  Fly   610 YGLITAALKSQPWRFHPRNRAQLLYDTYIFVSTDRLSHSILLELLGYLTNEQQYAPWSTA----N 670
            :..:.:.|::........||||:|.|.:.......::.::.|....||..|::|.||..|    |
Zfish   632 WERLLSQLETNHQTIPVVNRAQILDDAFNLARASIINITLALRTTKYLVREREYIPWEAALRSLN 696

  Fly   671 TILTVYDRYLRGDDSYYNFQDFVKRLIDPIFDKIGV-----NEIPGEHYLNNYLRIVLVSLACQV 730
            ....::||    ::.|...|.::|:.:.|:|:..|.     .::|..| .:.:.:|:.:||||..
Zfish   697 YFFQLFDR----NEVYGALQAYLKKQVKPLFEHFGTISSNWTKVPNGH-TDQFTQIIALSLACGT 756

  Fly   731 GSDDCYNQSANKLSEYLYNG--TAIEATLKTQAYC----AGLRSTTNEIYSRVQSDLLSSSDSTD 789
            |.:.|...:.:...:::.|.  ..|...|::..||    ||.....|..:...|...:::.....
Zfish   757 GVEGCREITKSWFKKWMQNPRVNPIHPNLRSTVYCNAIAAGGADEWNFGWQMFQKATVAAEAVKL 821

  Fly   790 RSLFISSLGCSGSTSQLLDFLRLSLDTNNSLSYSERTSLLNSAYSRSEIGLTAS--------LEF 846
            |    ::|.|: ....||         |..|.||.....:....:.|.||..||        .:|
Zfish   822 R----AALACT-KVPWLL---------NRYLEYSINPEKIRKQDATSTIGYIASNVIGQPLAWDF 872

  Fly   847 LESNWEAY------ANLSDSAKPLDAALRGIATYVVSEKQKTRLNALVDVVEADGPSYINDDLST 905
            :.:||:.:      .:.:.|....|...:....:.:|:.::                :..|:..|
Zfish   873 VRANWDYFFKVYGTGSFTFSRLISDITSKFCTPFELSQLKR----------------FQKDNAET 921

  Fly   906 TIDS----------RITSNFAWLEVNRDPVLNW 928
            ...|          |.|:...||..|::|||.|
Zfish   922 GFGSGTQALQQAIERTTAKIKWLAENKEPVLQW 954

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31343	NP_732652.1	Peptidase_M1	57..446	CDD:279741	152/417 (36%)
		M1_APN_2	65..517	CDD:189008	174/481 (36%)
		ERAP1_C	591..886	CDD:288671	70/323 (22%)
si:ch211-106j24.1	XP_021327531.1	M1_APN_2	77..543	CDD:189008	174/479 (36%)
si:ch211-106j24.1	XP_021327531.1	PepN	170..943	CDD:223385	249/834 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170590585
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X67
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	7	6.950