DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31343 and ERAP1

DIOPT Version :9

Sequence 1:	NP_732652.1	Gene:	CG31343 / 326133	FlyBaseID:	FBgn0051343	Length:	961	Species:	Drosophila melanogaster
Sequence 2:	XP_005272072.1	Gene:	ERAP1 / 51752	HGNCID:	18173	Length:	951	Species:	Homo sapiens

Alignment Length:	1010	Identity:	290/1010 - (28%)
Similarity:	455/1010 - (45%)	Gaps:	154/1010 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 RWLLNSFSLIL--LLAVCSLQARLILPLSLDDGQLETKGAALFATSRVDDNSA---GNYRLPNTT 62
            :|.|.:.|.:|  |||        :|.:|.......|:     |:.:..|.:.   ...|||...
Human     7 KWSLATMSFLLSSLLA--------LLTVSTPSWCQSTE-----ASPKRSDGTPFPWNKIRLPEYV 58

  Fly    63 EPESYNVELWTNVHNGDTEFNGTVNIDIRVLNETSNITLHYRQTSNFEATIISRDVATPTAIPLT 127
            .|..|::.:..|:..  ..|.||..::|.....||.|.||........||:........:..||.
Human    59 IPVHYDLLIHANLTT--LTFWGTTKVEITASQPTSTIILHSHHLQISRATLRKGAGERLSEEPLQ 121

  Fly   128 VTPELQREFLVLTQTTAGEAFGANTNWTITINYTGIHRSDMGGFYISSYTDDDGEQHFLATTQFE 192
            |....::|.:.|   .|.|.......:|:.|:|.|.......|||.|:|...:||...||:||||
Human   122 VLEHPRQEQIAL---LAPEPLLVGLPYTVVIHYAGNLSETFHGFYKSTYRTKEGELRILASTQFE 183

  Fly   193 STNARHAFPCYDEPARRANFTITIHHDPSYTAISNMP-VNTAATSSGVTA--FQTTPKMSTYLVA 254
            .|.||.||||:||||.:|:|:|.|..:|.:.|||||| |.:...:.|:..  |..|.||||||||
Human   184 PTAARMAFPCFDEPAFKASFSIKIRREPRHLAISNMPLVKSVTVAEGLIEDHFDVTVKMSTYLVA 248

  Fly   255 FIVSDFESTTG-ELNGIRQRVFSRKGKQDQQEWALWSGLLVESSLASYFGVPFALPKLDQAGIPD 318
            ||:|||||.:. ..:|::..|::...|.:|.::||.:.:.:......||.:|:.|||.|.|.|||
Human   249 FIISDFESVSKITKSGVKVSVYAVPDKINQADYALDAAVTLLEFYEDYFSIPYPLPKQDLAAIPD 313

  Fly   319 FSAGAMENWGLATYREQYMWWNKQNSTINLKTNIANIIGHEYAHMWFGDLVSIKWWTYLWLKEGF 383
            |.:||||||||.||||..:.::.:.|:.:.|..|...:.||.||.|||:||:::||..|||.|||
Human   314 FQSGAMENWGLTTYRESALLFDAEKSSASSKLGITMTVAHELAHQWFGNLVTMEWWNDLWLNEGF 378

  Fly   384 ATLFSYESNDIAFPLWDTYQIFHVNDY-----NSALLNDALASAVPMTHYVQTPSEISNRYNTFS 443
            |....:.|..:      |:....|.||     ..|:..|||.|:.|::..|:.|::|...::..|
Human   379 AKFMEFVSVSV------THPELKVGDYFFGKCFDAMEVDALNSSHPVSTPVENPAQIREMFDDVS 437

  Fly   444 YAKPASVLYMFKNAWTDKVFRTGLNKYLTKNQYTSC---DEWDLFASF----------------- 488
            |.|.|.:|.|.:...:...|::|:.:||.|:.|.:.   |.||..||.
Human   438 YDKGACILNMLREYLSADAFKSGIVQYLQKHSYKNTKNEDLWDSMASICPTDGVKGMDGFCSRSQ 502

  Fly   489 ---------QESADELGFTLPASVDDIFSSWSHQAGYPLLTVT-RNYNAGTITITQKRYVANK-- 541
                     ||..|         |..:.::|:.|.|:||:|:| |..|   :.:.|:.|:...
Human   503 HSSSSSHWHQEGVD---------VKTMMNTWTLQKGFPLITITVRGRN---VHMKQEHYMKGSDG 555

  Fly   542 -TDTNSATWYVPLNFATANKYDYRDTSATHYLLNVTETVI----SDVEASSDDWIIVNIQNSGYY 601
             .|| ...|:|||.|.|:.      :...|..|..|:|.:    .:||     ||..|:..:|||
Human   556 APDT-GYLWHVPLTFITSK------SDMVHRFLLKTKTDVLILPEEVE-----WIKFNVGMNGYY 608

  Fly   602 RTLYDTQNYGLITAALKSQPWRFHPRNRAQLLYDTYIFVSTDRLSHSILLELLGYLTNEQQYAP- 665
            ...|:...:..:|..||.........:||.|:.:.:..||..:||....|:|..||.:|.:..|
Human   609 IVHYEDDGWDSLTGLLKGTHTAVSSNDRASLINNAFQLVSIGKLSIEKALDLSLYLKHETEIMPV 673

  Fly   666 WSTANTILTVYDRYLRGD--DSYYNFQDFVKRLIDPIFDKI------GVNEIPGEHYLNNYLRIV 722
            :...|.::.:|....:.|  :....|:.|:.||:..:.||.      .|:|        ..||..
Human   674 FQGLNELIPMYKLMEKRDMNEVETQFKAFLIRLLRDLIDKQTWTDEGSVSE--------RMLRSQ 730

  Fly   723 LVSLACQVGSDDCYNQSANKLSEYL-YNGT---AIEATLKTQAYCAGLRSTT--NEIYSRVQSDL 781
            |:.|||......|..::.....::. .||.   .::.||  ..:..|.:||.  :.:||:.|..|
Human   731 LLLLACVHNYQPCVQRAEGYFRKWKESNGNLSLPVDVTL--AVFAVGAQSTEGWDFLYSKYQFSL 793

  Fly   782 LSSSDSTDRSLFISSLGCSGSTSQLLDFLRLSLDTNNSLSYSERTSLLNSAYSRSEIGLTASLEF 846
                .||::|....:| |.....:.|.:|.......:.:...|...:| :...|:.:|...:.:|
Human   794 ----SSTEKSQIEFAL-CRTQNKEKLQWLLDESFKGDKIKTQEFPQIL-TLIGRNPVGYPLAWQF 852

  Fly   847 LESNWEAYANLSDSAKPLDAALRGIATYVVSE----KQKTRLNALVDVVEADG-PSYINDD---- 902
            |..||      :...:..:.....||..|:..    ..:|||.      |..| .|.:.::
Human   853 LRKNW------NKLVQKFELGSSSIAHMVMGTTNQFSTRTRLE------EVKGFFSSLKENGSQL 905

  Fly   903 --LSTTIDSRITSNFAWLEVNRDPVLNWIEDSLKE 935
              :..||:: |..|..|::.|.|.:..|::....|
Human   906 RCVQQTIET-IEENIGWMDKNFDKIRVWLQSEKLE 939

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31343	NP_732652.1	Peptidase_M1	57..446	CDD:279741	149/397 (38%)
		M1_APN_2	65..517	CDD:189008	167/489 (34%)
		ERAP1_C	591..886	CDD:288671	72/313 (23%)
ERAP1	XP_005272072.1	M1_APN_2	61..531	CDD:189008	167/489 (34%)
ERAP1	XP_005272072.1	ERAP1_C	597..916	CDD:314669	78/347 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165155393
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0308
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X67
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.850