Protein Alignment CG31343 and ERAP1

DIOPT Version :10

• Sequence 1: NP_732652.1
• Gene: CG31343 / 326133
• FlyBaseID: FBgn0051343
• Length: 961
• Species: Drosophila melanogaster
• Sequence 2: XP_005272072.1
• Gene: ERAP1 / 51752
• HGNCID: 18173
• Length: 951
• Species: Homo sapiens
• Alignment Length: 1010
• Identity: 290/1010 - (28%)
• Similarity: 455/1010 - (45%)
• Gaps: 154/1010 - (15%)

  Fly     3 RWLLNSFSLIL--LLAVCSLQARLILPLSLDDGQLETKGAALFATSRVDDNSA---GNYRLPNTT 62
            :|.|.:.|.:|  |||        :|.:|.......|:     |:.:..|.:.   ...|||...
Human     7 KWSLATMSFLLSSLLA--------LLTVSTPSWCQSTE-----ASPKRSDGTPFPWNKIRLPEYV 58

  Fly    63 EPESYNVELWTNVHNGDTEFNGTVNIDIRVLNETSNITLHYRQTSNFEATIISRDVATPTAIPLT 127
            .|..|::.:..|:..  ..|.||..::|.....||.|.||........||:........:..||.
Human    59 IPVHYDLLIHANLTT--LTFWGTTKVEITASQPTSTIILHSHHLQISRATLRKGAGERLSEEPLQ 121

  Fly   128 VTPELQREFLVLTQTTAGEAFGANTNWTITINYTGIHRSDMGGFYISSYTDDDGEQHFLATTQFE 192
            |....::|.:.|   .|.|.......:|:.|:|.|.......|||.|:|...:||...||:||||
Human   122 VLEHPRQEQIAL---LAPEPLLVGLPYTVVIHYAGNLSETFHGFYKSTYRTKEGELRILASTQFE 183

  Fly   193 STNARHAFPCYDEPARRANFTITIHHDPSYTAISNMP-VNTAATSSGVTA--FQTTPKMSTYLVA 254
            .|.||.||||:||||.:|:|:|.|..:|.:.|||||| |.:...:.|:..  |..|.||||||||
Human   184 PTAARMAFPCFDEPAFKASFSIKIRREPRHLAISNMPLVKSVTVAEGLIEDHFDVTVKMSTYLVA 248

  Fly   255 FIVSDFESTTG-ELNGIRQRVFSRKGKQDQQEWALWSGLLVESSLASYFGVPFALPKLDQAGIPD 318
            ||:|||||.:. ..:|::..|::...|.:|.::||.:.:.:......||.:|:.|||.|.|.|||
Human   249 FIISDFESVSKITKSGVKVSVYAVPDKINQADYALDAAVTLLEFYEDYFSIPYPLPKQDLAAIPD 313

  Fly   319 FSAGAMENWGLATYREQYMWWNKQNSTINLKTNIANIIGHEYAHMWFGDLVSIKWWTYLWLKEGF 383
            |.:||||||||.||||..:.::.:.|:.:.|..|...:.||.||.|||:||:::||..|||.|||
Human   314 FQSGAMENWGLTTYRESALLFDAEKSSASSKLGITMTVAHELAHQWFGNLVTMEWWNDLWLNEGF 378

  Fly   384 ATLFSYESNDIAFPLWDTYQIFHVNDY-----NSALLNDALASAVPMTHYVQTPSEISNRYNTFS 443
            |....:.|..:      |:....|.||     ..|:..|||.|:.|::..|:.|::|...::..|
Human   379 AKFMEFVSVSV------THPELKVGDYFFGKCFDAMEVDALNSSHPVSTPVENPAQIREMFDDVS 437

  Fly   444 YAKPASVLYMFKNAWTDKVFRTGLNKYLTKNQYTSC---DEWDLFASF----------------- 488
            |.|.|.:|.|.:...:...|::|:.:||.|:.|.:.   |.||..||.
Human   438 YDKGACILNMLREYLSADAFKSGIVQYLQKHSYKNTKNEDLWDSMASICPTDGVKGMDGFCSRSQ 502

  Fly   489 ---------QESADELGFTLPASVDDIFSSWSHQAGYPLLTVT-RNYNAGTITITQKRYVANK-- 541
                     ||..|         |..:.::|:.|.|:||:|:| |..|   :.:.|:.|:...
Human   503 HSSSSSHWHQEGVD---------VKTMMNTWTLQKGFPLITITVRGRN---VHMKQEHYMKGSDG 555

  Fly   542 -TDTNSATWYVPLNFATANKYDYRDTSATHYLLNVTETVI----SDVEASSDDWIIVNIQNSGYY 601
             .|| ...|:|||.|.|:.      :...|..|..|:|.:    .:||     ||..|:..:|||
Human   556 APDT-GYLWHVPLTFITSK------SDMVHRFLLKTKTDVLILPEEVE-----WIKFNVGMNGYY 608

  Fly   602 RTLYDTQNYGLITAALKSQPWRFHPRNRAQLLYDTYIFVSTDRLSHSILLELLGYLTNEQQYAP- 665
            ...|:...:..:|..||.........:||.|:.:.:..||..:||....|:|..||.:|.:..|
Human   609 IVHYEDDGWDSLTGLLKGTHTAVSSNDRASLINNAFQLVSIGKLSIEKALDLSLYLKHETEIMPV 673

  Fly   666 WSTANTILTVYDRYLRGD--DSYYNFQDFVKRLIDPIFDKI------GVNEIPGEHYLNNYLRIV 722
            :...|.::.:|....:.|  :....|:.|:.||:..:.||.      .|:|        ..||..
Human   674 FQGLNELIPMYKLMEKRDMNEVETQFKAFLIRLLRDLIDKQTWTDEGSVSE--------RMLRSQ 730

  Fly   723 LVSLACQVGSDDCYNQSANKLSEYL-YNGT---AIEATLKTQAYCAGLRSTT--NEIYSRVQSDL 781
            |:.|||......|..::.....::. .||.   .::.||  ..:..|.:||.  :.:||:.|..|
Human   731 LLLLACVHNYQPCVQRAEGYFRKWKESNGNLSLPVDVTL--AVFAVGAQSTEGWDFLYSKYQFSL 793

  Fly   782 LSSSDSTDRSLFISSLGCSGSTSQLLDFLRLSLDTNNSLSYSERTSLLNSAYSRSEIGLTASLEF 846
                .||::|....:| |.....:.|.:|.......:.:...|...:| :...|:.:|...:.:|
Human   794 ----SSTEKSQIEFAL-CRTQNKEKLQWLLDESFKGDKIKTQEFPQIL-TLIGRNPVGYPLAWQF 852

  Fly   847 LESNWEAYANLSDSAKPLDAALRGIATYVVSE----KQKTRLNALVDVVEADG-PSYINDD---- 902
            |..||      :...:..:.....||..|:..    ..:|||.      |..| .|.:.::
Human   853 LRKNW------NKLVQKFELGSSSIAHMVMGTTNQFSTRTRLE------EVKGFFSSLKENGSQL 905

  Fly   903 --LSTTIDSRITSNFAWLEVNRDPVLNWIEDSLKE 935
              :..||:: |..|..|::.|.|.:..|::....|
Human   906 RCVQQTIET-IEENIGWMDKNFDKIRVWLQSEKLE 939

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG31343	NP_732652.1	M1_APN-Q_like	65..510	CDD:341064	164/482 (34%)
		ERAP1_C	590..889	CDD:463368	73/317 (23%)
ERAP1	XP_005272072.1	M1_APN-Q_like	61..526	CDD:341064	165/484 (34%)
		ERAP1_C	597..916	CDD:463368	78/347 (22%)