DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31343 and enpep

DIOPT Version :9

Sequence 1:	NP_732652.1	Gene:	CG31343 / 326133	FlyBaseID:	FBgn0051343	Length:	961	Species:	Drosophila melanogaster
Sequence 2:	NP_001186660.1	Gene:	enpep / 504088	ZFINID:	ZDB-GENE-050309-218	Length:	951	Species:	Danio rerio

Alignment Length:	1005	Identity:	268/1005 - (26%)
Similarity:	462/1005 - (45%)	Gaps:	165/1005 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 LLAVCSLQARLILPLSLD-DGQLETKGAALFATSRVDD-------NSAG---NYRLPNTTEPESY 67
            ::.|..:...|.:.|||: ..:.||.......|...||       |:.|   |:|||:...|..|
Zfish    26 VIVVTGVAVGLGVGLSLNSSSEKETPLPTPLPTEVPDDRPCKPSENTNGGWSNFRLPDYILPFHY 90

  Fly    68 NV----ELWTNVHNGDTEFNGTVNIDIRVLNETSNITLHYRQTSNFEATIISRDVATPTAIPLTV 128
            ::    :|.|:::.||      |::.:::...:.::.||.|.|.                  :||
Zfish    91 DLHMEPDLNTDIYTGD------VSVHLKLTQPSQHLWLHIRDTF------------------VTV 131

  Fly   129 TPELQR--------------------EFLVLTQTTAGEAFGANTNWTITINYTGIHRSDMGGFYI 173
            .|.|||                    |::|:.........|.:.::.:|:::.|.....:.|||.
Zfish   132 MPSLQRSSPSGVTSVKLKQCFEYKPQEYVVVEAAEQLSVTGPDEHYVLTLHFQGWLNGSLVGFYR 196

  Fly   174 SSYTDDDGEQHFLATTQFESTNARHAFPCYDEPARRANFTITIHHDPSYTAISNMPVNTA---AT 235
            ::| .::|....:|.|..|.|:||.:|||:|||.::|.:||:|.||.:|.|:|||||...   :.
Zfish   197 TTY-QENGVTKKIAATDHEPTDARKSFPCFDEPNKKATYTISITHDSTYKALSNMPVEKTEKLSE 260

  Fly   236 SSGVTAFQTTPKMSTYLVAFIVS--DFESTTGELNGIRQRVFSRKGKQDQQEWALWSGLLVESSL 298
            ....|:|..:.|||||||.|.|.  ||...|.: .||..|::::..:.....:|.....::....
Zfish   261 QKTKTSFMKSVKMSTYLVCFAVHQFDFVERTSK-RGIPLRIYAQPLQISTAAYAADVTQVIFDYF 324

  Fly   299 ASYFGVPFALPKLDQAGIPDFSAGAMENWGLATYREQYMWWN-KQNSTINLKTNIANIIGHEYAH 362
            ..||.:.:::.|||:..||||..||||||||.||||..:.:: |::|::| |..:|::|.||..|
Zfish   325 EEYFDMEYSIQKLDKIAIPDFGTGAMENWGLITYRETNLLFDEKESSSVN-KQRVASVIAHELVH 388

  Fly   363 MWFGDLVSIKWWTYLWLKEGFATLFSYESNDIAFPLWDTYQIFHVNDYNSALLNDALASAVPMTH 427
            .|||::|::.||..|||.||||:.|.|...:.|...|....:..:||....:::|||.|:.|:..
Zfish   389 QWFGNIVTMDWWDDLWLNEGFASFFEYIGVEEAEHDWGMRDVMLINDVYPVMVDDALLSSHPIIV 453

  Fly   428 YVQTPSEISNRYNTFSYAKPASVLYMFKNAWTDKVFRTG----LNKYLTKNQYTSCDEWDLFASF 488
            .|.:|:||::.::..||.|.||:|.|.::....:.||.|    |..||.:|..|| |.|
Zfish   454 DVSSPAEITSVFDAISYNKGASILRMLEDLLGRETFRDGCRRYLKTYLFQNAKTS-DFW------ 511

  Fly   489 QESADELGFTLPASVDDIFSSWSHQAGYPLLTVTRNYNAGT-ITITQKRYVAN-KTDTNSAT--- 548
            :..|||.|  ||  |.||..:|:.|.|||:|::|   |..| ..:||.|::.: ..|.:..|
Zfish   512 KALADESG--LP--VADIMDTWTKQMGYPVLSLT---NTDTEAKLTQTRFLLDPNADPSQPTTPL 569

  Fly   549 ---WYVPLNFATANKYDYRDTSATHYLL--NVTETVISDVEASSDDWIIVNIQNSGYYRTLYDTQ 608
               |.:|:      |:...|::...::.  ..||.|||....:::..|.||..:.|:||..:..|
Zfish   570 GYKWTIPV------KWKALDSTNNSFIFEKGQTEAVISGYSHATNGLIKVNKDHMGFYRVNHHDQ 628

  Fly   609 NYGLITAALKSQPWRFHPRNRAQLLYDTYIFVSTDRLSHSILLELLGYLTNEQQYAPWSTANTIL 673
            .:..|...|......:...:|:..:.|.:.....|.:.:.....|..||.:|.:|..|...:..:
Zfish   629 MWSDIAEQLLMDHQVYDATDRSSYIDDIFALGRADMVDYGNAFNLTRYLADETEYIVWDRVSASI 693

  Fly   674 TVYDRYLRGDDS--YYNFQDFVKRLIDPIFDKIGVNEIPGEHYLNNYLRIVLVSLACQVGSDDCY 736
            : |.|.:..||:  |..||...:..:..|..::|..:...:  ....||.:::.:|||:|..:..
Zfish   694 S-YVREMLADDTVLYPLFQKLFRGHVQKISRELGWKDEGNQ--TQRLLREIVLGIACQMGDQEAL 755

  Fly   737 NQSANKLSEYLYNGT--AIEATLKTQAYCAG-LRSTTNEIYSRVQSDLLSSSDSTDRSLFISSLG 798
            :|:::..:::: .||  ::...|:...|..| :.|.|.|.:..:....||::.:.::...:..|
Zfish   756 DQASDIFNKWI-KGTIGSVPVNLRLLVYRYGMMNSGTEESWEIMFQKYLSATLAQEKDKLLYGL- 818

  Fly   799 CSGSTSQLLDFLRLSLDTNNSLSYSERTSLLNSAYSRSEIGLTASLEFLESNWEAYANLSDSAKP 863
            .|.....||..| |....|.|:..|:....|....|||..|...:.:::..||:...|
Zfish   819 ASVKNIHLLHRL-LEATKNESIIRSQDVFTLVQYVSRSSDGKIMAWDWMTLNWDYLVN------- 875

  Fly   864 LDAALRGIATYVVSEKQKTRLNALVDVVEADGPSYINDDLSTTID-------------------- 908
                     .|.::::...||           |:.|....|:.:.
Zfish   876 ---------RYTINDRNLGRL-----------PARITTTYSSNLQLWKMEHFFALHPNAGAGEMP 920

  Fly   909 -----SRITSNFAWLEVNRDPVLNWIEDSL 933
                 ..:.:|..|:|.|:|.:..|:|:::
Zfish   921 RKQALETVKNNIEWVERNKDEIRFWLENNV 950

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31343	NP_732652.1	Peptidase_M1	57..446	CDD:279741	133/418 (32%)
		M1_APN_2	65..517	CDD:189008	157/485 (32%)
		ERAP1_C	591..886	CDD:288671	64/299 (21%)
enpep	NP_001186660.1	Peptidase_M1	80..473	CDD:279741	133/419 (32%)
		M1_APN_2	89..536	CDD:189008	157/484 (32%)
		ERAP1_C	611..927	CDD:288671	67/348 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X67
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	6.020