DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31343 and Lvrn

DIOPT Version :9

Sequence 1:	NP_732652.1	Gene:	CG31343 / 326133	FlyBaseID:	FBgn0051343	Length:	961	Species:	Drosophila melanogaster
Sequence 2:	XP_038953134.1	Gene:	Lvrn / 502160	RGDID:	1562779	Length:	993	Species:	Rattus norvegicus

Alignment Length:	965	Identity:	267/965 - (27%)
Similarity:	433/965 - (44%)	Gaps:	145/965 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 LLNSFSLILLLAV---------CS------LQARLILPLSLD--DGQLETKGA----ALFATS-- 46
            ||...:.:||||:         |:      |.:.|:...||.  .||..|:..    :...||
  Rat    18 LLAGLTAVLLLALVVLAALYGSCAHVQSSELDSHLVKDTSLSPPGGQEWTQPTPAHESTVGTSQD 82

  Fly    47 -RVDDNSAGNYRLPNTTEPESYNVELW-----TNVHNGDTEFNGTVNIDIRVLNETSNITLH--- 102
             |.......:.|||....|..|::|||     .|:......|.|.|||.:|....||.:.||
  Rat    83 WRPPSGPWDHLRLPPWLVPLHYDLELWPRLQPDNLSTPSLTFTGRVNITVRCTVATSTLLLHSFF 147

  Fly   103 --YRQTSNFEATIISRDVATPTAIPL-TVTPELQREFLVLTQTTAGEAFGANTNWTITINYTG-I 163
              |:|...:.........||...:|| .|...|..:::||   ..|::....:::.:..:::| :
  Rat   148 LNYKQVEVWGPLAPDTRNATVGRVPLENVWFALDMQYVVL---DLGQSLDPGSSYELNFDFSGQV 209

  Fly   164 HRSDMGGFYISSYTDDDGEQHFLATTQFESTNARHAFPCYDEPARRANFTITIHHDPSYTAISNM 228
            .:....|.:::.|||:| :...|..||.|.|.|||.|||:||||.:|.|.|||.|.|.|.|:|||
  Rat   210 LQEGSEGLFLNLYTDED-QLRALIATQMEPTFARHVFPCFDEPALKATFNITIIHHPGYVALSNM 273

  Fly   229 P-------VNTAATSSGVTAFQTTPKMSTYLVAFIVSDFESTTGELNGIRQRVFSRKGKQDQQEW 286
            |       ::...:...||:|.|||:|.|||||.::.||:..:....|...||::||..
  Rat   274 PQLGQSHRIDVNGSRWTVTSFHTTPRMPTYLVALVICDFDYVSRTERGKEIRVWARKDD------ 332

  Fly   287 ALWSGLL---------VESSLASYFGVPFALPKLDQAGIPDFSAGAMENWGLATYREQYMWWNKQ 342
             :..|.|         |.|.|...|.:.:.|||.|...:|.|..||||||||..: :..:.....
  Rat   333 -IADGYLDFAANHTGPVFSFLEDLFNISYPLPKTDIIALPTFVNGAMENWGLMIF-DASLLLELD 395

  Fly   343 NSTINLKTNIANIIGHEYAHMWFGDLVSIKWWTYLWLKEGFATLFSYESNDIAFPLWDTYQIFHV 407
            :.....:..|.:|:.||..|.|||:||::.||..:||.||||:.|.....:..:|......||.:
  Rat   396 DDLPEKRAMILSILSHEVGHQWFGNLVTMSWWNNIWLNEGFASYFEVGLTNYFYPKVPRNMIFFL 460

  Fly   408 NDYNSALLND----ALASAVPMTHYVQTPSEISNRYNTFSYAKPASVLYMFKNAWTDKVFRTGLN 468
            ...:..|.:|    :.|.:.|:.::.:| .||:..::.::|.|.|.:.:|.....:..:|...|.
  Rat   461 TVLHDILEDDHSLESRAVSTPVENFTET-REINRLFDIYTYKKGACMAWMLAGFLSQHLFINALK 524

  Fly   469 KYLTKNQYTSCDEWDLFASFQESADELGFT-LPASVDDIFSSWSHQAGYPLLTVTRNYNAGTITI 532
            .||....|::.::.||:...|.:.||.... |||:|..|..||:||:|:|::|:    ||.|..:
  Rat   525 SYLETFSYSNAEQDDLWRHIQMAIDEQSIIHLPATVKRIMDSWTHQSGFPVITL----NASTGVV 585

  Fly   533 TQKRY----VANKTDTNSATWYVPLNFATANKYDYRDTSATHYLLNVTETVI------------- 580
            .|:.:    |.|:|..:..||.||: |...|              .:|:.::
  Rat   586 KQEPFYLERVENQTLLSHNTWIVPI-FWMKN--------------GITQPLVWLDKSSMIFPGMK 635

  Fly   581 -SDVEASSDDWIIVNIQNSGYYRTLYDTQNYGLITAALKSQPWRFHPRNRAQLLYDTYIFVSTDR 644
             ||   |..||:|:|...:||||..||...:..:...|:..|......||.||:.|.:.....:.
  Rat   636 LSD---SDSDWVILNFNVTGYYRVNYDKLGWKKLNQQLEKDPKAIPVINRLQLVSDAFALSKNNY 697

  Fly   645 LSHSILLELLGYLTNEQQYAPWSTANTIL----TVYDRYLRGDDSYYNF----QDFVKRL--IDP 699
            :.....|:|..|:..|.:...|......|    .|||     ..:||.:    :.|:|||  |..
  Rat   698 IEIETALDLTKYIAKEDEILVWFEVLVNLINREVVYD-----VKNYYLYPLLKKYFLKRLNSIWT 757

  Fly   700 IFDKIGVNEIPGEHYLNNYLRIV----LVSLACQVGSDDCYNQSANKLSEYL-YNGTAIEATLKT 759
            |:..| :.|.... ..:|:|.::    ....||.:|.:||...|.....::: :..|||...::.
  Rat   758 IYSAI-IRENMAS-LQDNFLSLLPLKKFFETACWLGLEDCLQLSRELFRKWMAHPETAIPPQIEK 820

  Fly   760 QAYCAGLRSTTNEIYSRVQSDLLSSSDSTDRSLF--ISSLGCSGSTSQLLDFLRLSLDTNNSLSY 822
            ...|..:...:|:.:..:.:..::.::..: .||  :.::|||.....|..|:...:....| .:
  Rat   821 VVLCNAIALGSNKDWDFLFNLYINKTEEQE-DLFHLVHAMGCSKDPRTLNRFMEYDITVFPS-RF 883

  Fly   823 SERTSLLNSAYSRSEIGLTASLEFLESNWEAYANLSDSAKPLDAALRGIATYVVS 877
            :| |:|: ...:.||:|...:.:||.:||.|... |.|..||      :..|.||
  Rat   884 NE-TNLI-EVVAESEVGRYVAKDFLINNWVAVYE-SPSLSPL------LQQYFVS 929

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31343	NP_732652.1	Peptidase_M1	57..446	CDD:279741	133/420 (32%)
		M1_APN_2	65..517	CDD:189008	152/484 (31%)
		ERAP1_C	591..886	CDD:288671	73/304 (24%)
Lvrn	XP_038953134.1	M1_APN-Q_like	102..569	CDD:341064	149/479 (31%)
Lvrn	XP_038953134.1	ERAP1_C	643..915	CDD:403137	67/282 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166349299
Domainoid	1	1.000	108	1.000	Domainoid score	I6298
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.950