DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31343 and rnpep

DIOPT Version :9

Sequence 1:	NP_732652.1	Gene:	CG31343 / 326133	FlyBaseID:	FBgn0051343	Length:	961	Species:	Drosophila melanogaster
Sequence 2:	NP_001002741.1	Gene:	rnpep / 437014	ZFINID:	ZDB-GENE-040718-241	Length:	626	Species:	Danio rerio

Alignment Length:	726	Identity:	142/726 - (19%)
Similarity:	255/726 - (35%)	Gaps:	167/726 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 ETKGAALFATSRVDDNSAGNYRLPNTTEPESYNVELWTNVHNGDTEFNGTVNIDIRVLNET-SNI 99
            ::|...|::....|..::.::|   ..:.|.::::|  .|.......:||..|:::.:.:: |.:
Zfish     3 KSKTLTLYSDKAEDVATSSSFR---QFKIEHFHLDL--KVDFLQKSISGTETIELQCIQDSQSEL 62

  Fly   100 TLHYRQTSNFEATIISRDVATPTAIPLTVTPELQREFLVLTQTTAG--------EAFGANTNWTI 156
            .|....:.:.....:|::....|          :.|||....|:.|        .||.::....:
Zfish    63 QLDIHPSLSVHEITLSQNARDWT----------RTEFLTQDFTSYGTTLLVKFPTAFSSDDKLQL 117

  Fly   157 TINYTGIHRSDMGGFYISSYTDDDGEQHFLATTQFESTNARHAFPCYDEPARRANFTITIHHDPS 221
            .|.||.   :|..|..........|:......||.::...|..|||:|.||.::.::..:.....
Zfish   118 AIRYTA---TDGPGVCWLEPEQTAGKLKPYVFTQGQAVLNRSCFPCFDTPAVKSTYSAAVQVPDG 179

  Fly   222 YTAISNMPVNTAATSSGVTAFQTTPKMSTYLVAFIVSDFESTTGELNGIRQRVFS-----RKGKQ 281
            :||:.:........:.|...|.....:..||||..|.|.:|  .|: |.|.||::     :..||
Zfish   180 FTAVMSANKWEQRKADGAFLFTMEHPIPAYLVALAVGDLQS--AEV-GPRTRVWTEPCLLQAAKQ 241

  Fly   282 DQQEWALWSGLLVESSLA---SYFGVPFALPKLDQAGI-PDFSAGAMENWGLATYREQYMWWNKQ 342
            :...       ::|..|:   ..|| |:...:.|...: |.|..|.|||..|.......:..::
Zfish   242 EYDN-------VIEDFLSVGEKLFG-PYVWGRYDVLFMPPSFPFGGMENPCLTFVTPCLLAGDR- 297

  Fly   343 NSTINLKTNIANIIGHEYAHMWFGDLVSIKWWTYLWLKEGFATLFSYESNDIAFPLW-DTYQIFH 406
                    ::|::|.||..|.|||:||:...|...||.|||.   .|....:...|: :.|....
Zfish   298 --------SLADVIVHEICHSWFGNLVTNATWGDFWLNEGFT---MYAQRRVCRELYGEAYTCLE 351

  Fly   407 VNDYNSALLN---DALASAVPMTHY---VQTPSEISNRYNTFSYAKP-ASVLYMFKNAWTDKVFR 464
            ... ..|||.   |......|:...   ::...:..:.||...|.|. ..|.|:.........|.
Zfish   352 AAT-GKALLRQHMDNTGEDHPLNKLRVKIEPGVDPDDTYNETPYEKGFCFVSYLAHLTGDQSRFD 415

  Fly   465 TGLNKYLTKNQYTSCDEWDLFASFQESADELGFTLPASVDDI-FSSWSHQAGYPLLTVTRNYNAG 528
            |.|..|:.|.::.|....|....:.|...||.......::.: |.||.:..|:|.
Zfish   416 TFLKAYVEKFKFRSVLAEDALEFYLEYFPELKERNVHKIEGLDFDSWLNVPGWPP---------- 470

  Fly   529 TITITQKRYVANKTDTNSATWYVPLNFATANKYDYRDTSATHYLLNVTETVISDVEASSDDWIIV 593
                                 |||            |.||       .:|::...|..::.|:..
Zfish   471 ---------------------YVP------------DLSA-------GQTLMKPAELLAEKWLSH 495

  Fly   594 NIQNSGY----------YRTLYDTQNYGLITAALKSQPWRFHPRNRAQLLYDTYIFVSTDRLSHS 648
            |:.....          |:|:|      .:...|:..|.   |....:.|.:.|..:.  :.:::
Zfish   496 NLDLESICKTDLKSWKTYQTVY------FLDRILEKSPL---PDGNLKKLEECYSQII--KSNNA 549

  Fly   649 ILLELLGYLTNEQQYAP-----------WSTANTILTVYDRYLRGDDS----------------Y 686
            .|......:..:.||:|           .......|.||.....|.:.                :
Zfish   550 ELKVRWAQIVAKNQYSPGFQHIRDFLSSQGKQKYTLPVYRALWNGSEETKALAIEMFSATSGQLH 614

  Fly   687 YNFQDFVKRLI 697
            .|.:::||::|
Zfish   615 VNVRNYVKKII 625

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31343	NP_732652.1	Peptidase_M1	57..446	CDD:279741	91/413 (22%)
		M1_APN_2	65..517	CDD:189008	107/478 (22%)
		ERAP1_C	591..886	CDD:288671	21/144 (15%)
rnpep	NP_001002741.1	leuko_A4_hydro	16..623	CDD:274120	138/709 (19%)
		M1_LTA4H	16..464	CDD:189006	108/489 (22%)
		Leuk-A4-hydro_C	484..624	CDD:286244	22/150 (15%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0308
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.900