DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31343 and npepps

DIOPT Version :9

Sequence 1:	NP_732652.1	Gene:	CG31343 / 326133	FlyBaseID:	FBgn0051343	Length:	961	Species:	Drosophila melanogaster
Sequence 2:	NP_001157499.1	Gene:	npepps / 407726	ZFINID:	ZDB-GENE-060524-3	Length:	872	Species:	Danio rerio

Alignment Length:	912	Identity:	259/912 - (28%)
Similarity:	433/912 - (47%)	Gaps:	95/912 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    57 RLPNTTEPESYNVELWTNVHNGDTEFNGTVNIDIRVLNETSNITLHYRQTSNFEATIISRDVATP 121
            |||....|.:|.:.|..::  .|..|.|.:...:.|...|:.|.::....          |:.|.
Zfish     9 RLPTDVYPVNYGLRLKPDL--VDFTFEGKLEAAVEVTQGTNQIVMNCADI----------DIITA 61

  Fly   122 TAIP-----LTVTP-ELQREFLVLT---QTTAGEAFGANTNWTITINYTGIHRSDMGGFYISSYT 177
            :.:|     :..|. ..|.|...:|   .:|..:..|     ::.|::.|.....|.|||.|.|:
Zfish    62 SFVPDGGEEINATGFNYQNEDEKVTLCFPSTLQKGSG-----SLKIDFVGELNDKMKGFYRSKYS 121

  Fly   178 DDDGEQHFLATTQFESTNARHAFPCYDEPARRANFTITIHHDPSYTAISNMPV----NTAATSSG 238
             ..||..:.|.||||:|:||.||||:||||.:|.|.||:.......|:|||.|    ..|...|.
Zfish   122 -SSGEVRYAAVTQFEATDARRAFPCWDEPAIKATFDITLIVPKDRVALSNMNVVDRKPYAEDQSL 185

  Fly   239 V-TAFQTTPKMSTYLVAFIVSDFESTTGE-LNGIRQRVFSRKGKQDQQEWALWSGLLVESSLASY 301
            | ..|.|||.||||||||::.:::....: .:|:..||::..||.:|.::||............|
Zfish   186 VEVKFATTPIMSTYLVAFVIGEYDFVESQSSDGVTVRVYTPVGKAEQGKFALEVATKTLPFYKDY 250

  Fly   302 FGVPFALPKLDQAGIPDFSAGAMENWGLATYREQYMWWNKQNSTINLKTNIANIIGHEYAHMWFG 366
            |.||:.|||:|...|.||:|||||||||.||||..:..:.:||..:.:..:|.::|||.||.|||
Zfish   251 FSVPYPLPKIDLIAIADFAAGAMENWGLVTYRETALLIDPKNSCASSRQWVALVVGHELAHQWFG 315

  Fly   367 DLVSIKWWTYLWLKEGFATLFSYESNDIAFPLWDTYQIFHVNDYNSALLNDALASAVPMTHYVQT 431
            :||:::|||:|||.||||:...|...|..||.:|.:..|...||..||..|||.::.|:...|..
Zfish   316 NLVTMEWWTHLWLNEGFASWIEYLCVDHCFPEYDIWTQFVSADYTRALDLDALDNSHPIEVDVGH 380

  Fly   432 PSEISNRYNTFSYAKPASVLYMFKNAWTDKVFRTGLNKYLTKNQYTSCDEWDLFASFQESADELG 496
            |||:...::..||:|.|||:.|..|...|:.||.|:|.||.|.|:.:....||:...::::.:
Zfish   381 PSEVDEIFDAISYSKGASVIRMLHNYIGDEDFRKGMNAYLLKFQHKNASTEDLWECLEQASGK-- 443

  Fly   497 FTLPASVDDIFSSWSHQAGYPLLTVTRNYNAG--TITITQKRYVAN--KTDTNSATWYVPLNFAT 557
                 .:..:.:||:.|.|:|::.|.:..:..  .:.|:||::.|:  :.|.:...|.||::..|
Zfish   444 -----PIAAVMNSWTKQMGFPIIVVDQEQHGSDRVLKISQKKFCASGPRNDEDCPNWMVPISICT 503

  Fly   558 ANKYDYRDTSA--THYLLNVTETVISDVEASSDDWIIVNIQNSGYYRTLYDTQNYGLITAALKS- 619
            :     .|.|.  |..||:..||.::....:.|.||.:|....|:||..|.       :|.|:|
Zfish   504 S-----EDPSCTKTKILLDQPETTVNITNVAPDHWIKINPGTVGFYRIQYS-------SAMLESL 556

  Fly   620 ----QPWRFHPRNRAQLLYDTYIFVSTDRLSHSILLELLGYLTNEQQYAPWSTANTILTVYDRYL 680
                :.....|.:|..|..|.:.......:|...:|:::....||..|..||..:..|.|....|
Zfish   557 LPGIRDLTLLPVDRLGLQNDLFSLARAGMISTVEVLKVMEAFVNEPNYTVWSDLSCNLGVLSSLL 621

  Fly   681 RGDDSYYNFQDFVKRLIDPIFDKIGVNEIPGEHYLNNYLRIVLVSLACQVGSDDCYNQSANKLSE 745
            ...|.:.:.|:|::.|..||..|:|.:...||.:|:..||.:::....:.|......::..:..|
Zfish   622 SHTDFHEDIQEFIRDLFTPIGMKLGWDSRTGEGHLDALLRGLVLGKLGKAGHKATLEEARRRFRE 686

  Fly   746 YLYNGTAIEATLKTQAYCAGLR---STTNEIYSRV--QSDLLSSSDSTDRSLFISSLGCSGSTSQ 805
            ::.....:.|.|::..|...|:   |||.:...::  |:|:....:..:|.|  .::.......:
Zfish   687 HVEGKQILSADLRSPVYLTVLKHGDSTTLDTMLKLHKQADMQEEKNRIERVL--GAIPAPDLIQR 749

  Fly   806 LLDFLRLSLDTNNSLSYSERTSLLNSAYSRSEIGLTASLEFLESNWEAYANLSDSAKPLDAALRG 870
            :|:|.     .:..:...:..|::......|:.|..|:.:|::.|||...|            |.
Zfish   750 VLNFA-----LSEEVRPQDTVSVIGGVAGSSKQGRKAAWKFVKDNWEELHN------------RY 797

  Fly   871 IATYVVSEKQKTRLNAL-VDVVEADGPSYINDDLSTTID-------SRITSNFAWLEVNRDPVLN 927
            ...:::|...|..::.. :|.:.|:..|:.....:...:       ..|..|.|||:.:.|.:..
Zfish   798 QGGFLISRLIKLTVDGFAIDKMAAEVKSFFESHHAPAAERTVQQCCENILLNAAWLKRDADDIHQ 862

  Fly   928 WI 929
            ::
Zfish   863 YL 864

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31343	NP_732652.1	Peptidase_M1	57..446	CDD:279741	146/403 (36%)
		M1_APN_2	65..517	CDD:189008	163/466 (35%)
		ERAP1_C	591..886	CDD:288671	63/304 (21%)
npepps	NP_001157499.1	Peptidase_M1	9..396	CDD:279741	146/404 (36%)
		M1_APN_2	17..459	CDD:189008	163/466 (35%)
		ERAP1_C	534..845	CDD:288671	66/336 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0308
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X67
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.820