Protein Alignment CG31343 and LTA4H

DIOPT Version :9

• Sequence 1: NP_732652.1
• Gene: CG31343 / 326133
• FlyBaseID: FBgn0051343
• Length: 961
• Species: Drosophila melanogaster
• Sequence 2: NP_000886.1
• Gene: LTA4H / 4048
• HGNCID: 6710
• Length: 611
• Species: Homo sapiens
• Alignment Length: 573
• Identity: 127/573 - (22%)
• Similarity: 222/573 - (38%)
• Gaps: 113/573 - (19%)

  Fly    85 TVNIDIRVLNETSNITLHYRQTSNFEATIISRDVATPTAIPLTVTPELQREFLVLTQTTAGE--- 146
            :|:...|.|..|:.:|:. .|..|..:.::  |....|...:.:..:..:..|...|:..|.
Human    27 SVDFTRRTLTGTAALTVQ-SQEDNLRSLVL--DTKDLTIEKVVINGQEVKYALGERQSYKGSPME 88

  Fly   147 -----AFGANTNWTITINYTGIHRSDMGGFYISSYTDDDGEQHFLATTQFESTNARHAFPCYDEP 206
                 |...|....|.|::....:|....:.....|  .|::|....:|.::.:.|...||.|.|
Human    89 ISLPIALSKNQEIVIEISFETSPKSSALQWLTPEQT--SGKEHPYLFSQCQAIHCRAILPCQDTP 151

  Fly   207 ARRANFTITIHHDPSYTAISNMPVNTAATSSGVTAFQT-TPK--------------MSTYLVAFI 256
            :.:.          :|||..::|....|..|.:...:| .|:              :..||:|.:
Human   152 SVKL----------TYTAEVSVPKELVALMSAIRDGETPDPEDPSRKIYKFIQKVPIPCYLIALV 206

  Fly   257 VSDFESTTGELNGIRQRVFSRKGKQDQQEWALWSGLLVESSL--ASYFGVPFALPKLDQAGI-PD 318
            |...||   ...|.|..|:|.|   :|.|.:.:.....||.|  |...|.|:...:.|...: |.
Human   207 VGALES---RQIGPRTLVWSEK---EQVEKSAYEFSETESMLKIAEDLGGPYVWGQYDLLVLPPS 265

  Fly   319 FSAGAMENWGLATYREQYMWWNKQNSTINLKTNIANIIGHEYAHMWFGDLVSIKWWTYLWLKEGF 383
            |..|.|||..|.......:..:|         :::|:|.||.:|.|.|:||:.|.|.:.||.||.
Human   266 FPYGGMENPCLTFVTPTLLAGDK---------SLSNVIAHEISHSWTGNLVTNKTWDHFWLNEGH 321

  Fly   384 ATLFSYESNDIAFPLW-DTYQIFHVNDYNSALLND--ALASAVPMTHYVQTPSEISN--RYNTFS 443
            ..   |....|...|: :.::.|:.......|.|.  ......|.|..|...::|..  .|::..
Human   322 TV---YLERHICGRLFGEKFRHFNALGGWGELQNSVKTFGETHPFTKLVVDLTDIDPDVAYSSVP 383

  Fly   444 YAKPASVL-YMFKNAWTDKVFRTGLNKYLTKNQYTS--CDEWD--LFASFQESADELGFTLPASV 503
            |.|..::| |:.:.....::|...|..|:.|..|.|  .|:|.  |::.|::..|.|.     .|
Human   384 YEKGFALLFYLEQLLGGPEIFLGFLKAYVEKFSYKSITTDDWKDFLYSYFKDKVDVLN-----QV 443

  Fly   504 DDIFSSWSHQAGYPLLTVTRNYNA----GTITITQKRYVANKTDTNSATWYVPLNFATANKYDYR 564
            |  :::|.:..|.|  .:..||:.    ..|.::|:...|.:.|.||           .|..|.:
Human   444 D--WNAWLYSPGLP--PIKPNYDMTLTNACIALSQRWITAKEDDLNS-----------FNATDLK 493

  Fly   565 DTSATHYLLNVTETVISDVEASSDDWIIVNIQNS----GYYRTLYDTQNYGLI 613
            |.| :|.|               ::::...:|.:    |:.:.:.:..|:..|
Human   494 DLS-SHQL---------------NEFLAQTLQRAPLPLGHIKRMQEVYNFNAI 530

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG31343	NP_732652.1	Peptidase_M1	57..446	CDD:279741	89/391 (23%)
		M1_APN_2	65..517	CDD:189008	108/467 (23%)
		ERAP1_C	591..886	CDD:288671	4/27 (15%)
LTA4H	NP_000886.1	leuko_A4_hydro	6..608	CDD:274120	127/573 (22%)
		Substrate binding. /evidence=ECO:0000269|PubMed:18804029	135..137		1/1 (100%)
		Substrate binding. /evidence=ECO:0000269|PubMed:18804029	267..272		1/4 (25%)
		Inhibitor ARM1 binding. /evidence=ECO:0000269|PubMed:24591641	362..365		1/2 (50%)
		Substrate binding. /evidence=ECO:0000269|PubMed:18804029	564..566

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0308
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810