DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG31343 and LNPEP

DIOPT Version :9

Sequence 1:NP_732652.1 Gene:CG31343 / 326133 FlyBaseID:FBgn0051343 Length:961 Species:Drosophila melanogaster
Sequence 2:NP_005566.2 Gene:LNPEP / 4012 HGNCID:6656 Length:1025 Species:Homo sapiens


Alignment Length:978 Identity:279/978 - (28%)
Similarity:449/978 - (45%) Gaps:138/978 - (14%)


- Green bases have known domain annotations that are detailed below.


  Fly    11 LILLLAVCSLQAR----------LILPLSLDDGQLETKGAALFATSRVDDNSAGNYRLPNTTEPE 65
            :|.||..|:....          ||.|.:       |.| .||..:::        |||....|.
Human   127 VIYLLPRCTFTKEGCHKKNQSIGLIQPFA-------TNG-KLFPWAQI--------RLPTAVVPL 175

  Fly    66 SYNVELWTNVHNGDTEFNGTVNIDIRVLNETSNITLHYRQTSNFEATIISRDVATPTAIPLTVTP 130
            .|.:.|..|:.:  ..|.|:|.|.::.|..|.||.||          ....:::..|.:....:.
Human   176 RYELSLHPNLTS--MTFRGSVTISVQALQVTWNIILH----------STGHNISRVTFMSAVSSQ 228

  Fly   131 ELQREFLVLT-----QTTAGEAFGANTNWTITINYTGIHRSDMGGFYISSYTDDDGEQHFLATTQ 190
            |.|.|.|...     ...|.||..|..|:|:.|.|:....|...|||..||||:..|:.:.|.||
Human   229 EKQAEILEYAYHGQIAIVAPEALLAGHNYTLKIEYSANISSSYYGFYGFSYTDESNEKKYFAATQ 293

  Fly   191 FESTNARHAFPCYDEPARRANFTITIHHDPSYTAISNMPVNTAAT-SSGVT--AFQTTPKMSTYL 252
            ||...||.||||:||||.:|.|.|.|..|..|||:||||..::.. ..|:.  .|..:.||||||
Human   294 FEPLAARSAFPCFDEPAFKATFIIKIIRDEQYTALSNMPKKSSVVLDDGLVQDEFSESVKMSTYL 358

  Fly   253 VAFIVSDFESTTGELNGIRQRVFSRKGKQDQQEWALWSGLLVESSLASYFGVPFALPKLDQAGIP 317
            |||||.:.::.:.::||....:::...|..|..:||.:.:.:.....:||.:.:.|.|||...||
Human   359 VAFIVGEMKNLSQDVNGTLVSIYAVPEKIGQVHYALETTVKLLEFFQNYFEIQYPLKKLDLVAIP 423

  Fly   318 DFSAGAMENWGLATYREQYMWWNKQNSTINLKTNIANIIGHEYAHMWFGDLVSIKWWTYLWLKEG 382
            ||.|||||||||.|:||:.:.::...|::..:..:..||.||.||.|||:||::|||..|||.||
Human   424 DFEAGAMENWGLLTFREETLLYDSNTSSMADRKLVTKIIAHELAHQWFGNLVTMKWWNDLWLNEG 488

  Fly   383 FATLFSYESNDIAFPLWDTYQIFHVNDYNSALLNDALASAVPMTHYVQTPSEISNRYNTFSYAKP 447
            |||...|.|.:..|....:|:.| ::.....:..|:|.|:.|::..||:..:|...:::.||.|.
Human   489 FATFMEYFSLEKIFKELSSYEDF-LDARFKTMKKDSLNSSHPISSSVQSSEQIEEMFDSLSYFKG 552

  Fly   448 ASVLYMFKNAWTDKVFRTGLNKYLTKNQYTSCDEWDLFASFQESADELGFTLPASVDDIFSSWSH 512
            :|:|.|.|...::.||:..:..||..:.|.|....||:.||.|..::   ||  .|..:..:|:.
Human   553 SSLLLMLKTYLSEDVFQHAVVLYLHNHSYASIQSDDLWDSFNEVTNQ---TL--DVKRMMKTWTL 612

  Fly   513 QAGYPLLTVTRNYNAGTITITQKRYVAN------KTDTNSATWYVPLNFAT--ANKYDYRDTSAT 569
            |.|:||:||.:  ....:.|.|:|:..|      .:|| |..|::||::.|  .|...|:..|..
Human   613 QKGFPLVTVQK--KGKELFIQQERFFLNMKPEIQPSDT-SYLWHIPLSYVTEGRNYSKYQSVSLL 674

  Fly   570 HY---LLNVTETVISDVEASSDDWIIVNIQNSGYYRTLYDTQNYGLITAALKSQPWRFHPRNRAQ 631
            ..   ::|:||.|:         |:.|||..:|||...|...::..:...||..|:....::||.
Human   675 DKKSGVINLTEEVL---------WVKVNINMNGYYIVHYADDDWEALIHQLKINPYVLSDKDRAN 730

  Fly   632 LLYDTYIFVSTDRLSHSILLELLGYLTNEQQYAPWSTANTILTVYDRYLRGDDSYYN------FQ 690
            |:.:.:......::......:|:.||.||...||.:.|          |...|..||      :.
Human   731 LINNIFELAGLGKVPLKRAFDLINYLGNENHTAPITEA----------LFQTDLIYNLLEKLGYM 785

  Fly   691 DFVKRLIDPIFDKIGVNEIPGEHYLN------NYLRIVLVSLACQVGSDDCYNQSANKLSEYL-Y 748
            |...||:..:| |:..|:|..:.:.:      ..||..|:..||.....:|...:.....::: .
Human   786 DLASRLVTRVF-KLLQNQIQQQTWTDEGTPSMRELRSALLEFACTHNLGNCSTTAMKLFDDWMAS 849

  Fly   749 NGT-AIEATLKTQAYCAGLRSTTNEIYSRVQSDLLSSSDSTDRSLFISSLGCSGSTSQLLDFLRL 812
            ||| ::...:.|..:..|.:  |::.:|.:....:|.....:::..:.:|..|....:|...::.
Human   850 NGTQSLPTDVMTTVFKVGAK--TDKGWSFLLGKYISIGSEAEKNKILEALASSEDVRKLYWLMKS 912

  Fly   813 SLDTNN----SLSYSERTSLLNSAYSRSEIGLTASLEFLESNWEAYANLSDSAKPLDA-ALRGI- 871
            ||:.:|    .||:..||      ..|...|...:.:|::.||    |......||.: .::.| 
Human   913 SLNGDNFRTQKLSFIIRT------VGRHFPGHLLAWDFVKENW----NKLVQKFPLGSYTIQNIV 967

  Fly   872 --ATYVVSEKQKTRLNALVDVVEADGPSYINDDLSTTIDSR--------ITSNFAWLEVNRDPVL 926
              :||:.|  .||.|:.:        .::..:....|...|        |..|..|:|.|...:.
Human   968 AGSTYLFS--TKTHLSEV--------QAFFENQSEATFRLRCVQEALEVIQLNIQWMEKNLKSLT 1022

  Fly   927 NWI 929
            .|:
Human  1023 WWL 1025

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG31343NP_732652.1 Peptidase_M1 57..446 CDD:279741 144/396 (36%)
M1_APN_2 65..517 CDD:189008 162/459 (35%)
ERAP1_C 591..886 CDD:288671 71/316 (22%)
LNPEPNP_005566.2 Dileucine internalization motif. /evidence=ECO:0000255 53..54
Dileucine internalization motif. /evidence=ECO:0000255 76..77
Tankyrase binding 96..101
M1_APN_2 175..617 CDD:189008 162/459 (35%)
Substrate binding. /evidence=ECO:0000250 428..432 3/3 (100%)
ERAP1_C 689..1009 CDD:314669 75/352 (21%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165155404
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG0308
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D110058at2759
OrthoFinder 1 1.000 - - FOG0000044
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR11533
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X67
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
76.850

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