DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31343 and erap1b

DIOPT Version :9

Sequence 1:	NP_732652.1	Gene:	CG31343 / 326133	FlyBaseID:	FBgn0051343	Length:	961	Species:	Drosophila melanogaster
Sequence 2:	NP_956500.2	Gene:	erap1b / 393175	ZFINID:	ZDB-GENE-040426-934	Length:	963	Species:	Danio rerio

Alignment Length:	985	Identity:	267/985 - (27%)
Similarity:	429/985 - (43%)	Gaps:	191/985 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    57 RLPNTTEPESYNVELWTNVHNGDTEFNGTVNIDIRVLNETSNITLHYRQTSNFEATIISRDVATP 121
            |||:|..|..||:.:..|:.:.|  |.|:|.|.|.||.:|..|.||.:......|.::..::|..
Zfish    46 RLPDTISPLHYNLLIHPNLTSLD--FTGSVQIQIEVLQDTKTIILHSKNLQISSARLLDANIAQQ 108

  Fly   122 TAIPLTVTPELQREFLVLTQT--TAGEAFGANTNWTITINYTGIHRSDMGGFYISSYTDDDGEQH 184
            ..:.:...|..|:..||..:.  ..|..:....::...::      ....|||.|:|....|:..
Zfish   109 QPLKVLEYPYFQQIALVSDKALLKRGHVYSVELHFAANLS------ESFHGFYKSTYRTSKGDVR 167

  Fly   185 FLATTQFESTNARHAFPCYDEPARRANFTITIHHDPSYTAISNMP-VNTAATSSGV--TAFQTTP 246
            .:|:||||:|:||.||||:||||.:|||::.|..:..:.|:|||| :.|....:|:  ..|..:.
Zfish   168 VVASTQFEATSARAAFPCFDEPAFKANFSVQIRREAKHIALSNMPKLRTLELKNGLFEDQFDVSV 232

  Fly   247 KMSTYLVAFIVSDFES-TTGELNGIRQRVFSRKGKQDQQEWALWSGLLVESSLASYFGVPFALPK 310
            ||||||||:|||||.| :....:|::..|::...|.||.|:||.:.:.:......||.:|:.|||
Zfish   233 KMSTYLVAYIVSDFLSISKTSQHGVQISVYAVPEKIDQAEFALDAAVKLLDFYDDYFDIPYPLPK 297

  Fly   311 --------------------LDQAGIPDFSAGAMENWGLATYREQYMWWNKQNSTINLKTNIANI 355
                                :|.|.||||.:||||||||.||||..:.::...|:.:.|..|..|
Zfish   298 QEKPTIKHAKEEFSVYIICFVDLAAIPDFQSGAMENWGLTTYRESALLFDPHKSSASDKLGITMI 362

  Fly   356 IGHEYAHMWFGDLVSIKWWTYLWLKEGFATLFSYESNDIAFPLWDTYQIFHVNDY-----NSALL 415
            |.||.||.|||:||:::||..|||.||||....:.|.:|..|      ...|.||     ..|:.
Zfish   363 IAHELAHQWFGNLVTMQWWNDLWLNEGFAKFMEFVSVNITNP------ELQVEDYFLGKCFEAME 421

  Fly   416 NDALASAVPMTHYVQTPSEISNRYNTFSYAKPASVLYMFKNAWTDKVFRTGLNKYLTKNQYTS-- 478
            .|:|:|:.|::..|:.|::|...::..||.|.|.:|.|.:...|.|:|:.|:.|||....|.:
Zfish   422 VDSLSSSHPVSTPVENPAQIQEMFDDVSYDKGACILNMLREFLTPKIFKLGIVKYLKHYSYQNTV 486

  Fly   479 -----------CDEWDL-------FASFQESADELGFTLPASVDDI-----FSSWSHQAGYPLLT 520
                       ||...|       ..|.:.||...|.:...|.|::     ..:|:.|.|:||:|
Zfish   487 NSNLWESLTNVCDSDGLDEGRLKGDESCRHSASNTGASKWHSEDELDVKAMMETWTLQEGFPLIT 551

  Fly   521 VTRNYNAGTITITQKRYVANKTD----TNSATWYVPLNFATANKYDYRDTSATHYLLNVTETVI- 580
            :.  .....:.::|:||:  |:|    |:|..|.|||.:.|:      |::..|..|..|:|.:
Zfish   552 IA--VKGREVRLSQERYL--KSDDLSQTSSFLWQVPLTYITS------DSTTVHRFLLKTKTDVL 606

  Fly   581 ---SDVEASSDDWIIVNIQNSGYYRTLYDTQNYGLITAALKSQPWRFHPRNRAQLLYDTYIFVST 642
               .:|     |||..|:..||||...|:...:..:...||.........:||.|:.:.:..||.
Zfish   607 YLPEEV-----DWIKFNVDMSGYYIVHYEGSGWDDLITLLKHNHTALSSNDRASLINNAFQLVSV 666

  Fly   643 DRLSHSILLELLGYLTNEQQYAPWSTA-NTILTVYDRYLRGDDSYYNFQDFVKRLIDPIFDKIGV 706
            .:|.....|:|..||:.|.:..|.:.. |.::.:|....:.|  ....::.:|..|..:|.|:..
Zfish   667 GKLPLDKALDLTLYLSKETEIMPVTQGFNELVPLYKLMEKRD--MVELENQMKGYILQLFQKLIE 729

  Fly   707 NEI------PGEHYLNNYLRIVLVSLACQVGSDDCYNQSANKLSEYLYNGTAIEATLKTQAY--- 762
            .::      ..|..|.:||.:    ..|..|...|.:.:                   ||.:
Zfish   730 QQLWTDEGSVSERMLRSYLLL----FGCVRGHPPCVSNA-------------------TQLFNLW 771

  Fly   763 --CAGLRSTTNEIYSRVQSDLLSSSDSTD-------RSLFIS-------SLGCSGSTSQLLDFLR 811
              ..|..|..|::...|.|....:.|..|       .|:::|       :|..|....:|...:.
Zfish   772 RDSDGNMSLPNDVTMAVFSVGARTEDGWDFLFEKYKESMYVSMKSRIKQALMTSPLDHKLKWMME 836

  Fly   812 LSLDTNNSLSYSERTSLLNSAYSRSEIGLTASLEFLESNWEAYANLSDSAKPLDAALRGIATYV- 875
            .||:  ..|..::....:.::.||:......:.:||::||::.      .|..|.....||..|
Zfish   837 QSLE--GELIKTQDLPYVVTSVSRNPKAYKHAWDFLQANWDSL------IKKFDLGSHSIAHMVV 893

  Fly   876 -VSEKQKTR--------------------LNALVDVVEADGPSYINDDLSTTIDSRITSNFAWLE 919
             |:.:..||                    |..:...||                 .|..|..|::
Zfish   894 GVTNQYSTREMLAEVRNFFSLLQPETGAELRCIQQAVE-----------------NIEENIRWMD 941

  Fly   920 VNRDPVLNWI 929
            .|...:..|:
Zfish   942 KNLPLLKAWL 951

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31343	NP_732652.1	Peptidase_M1	57..446	CDD:279741	146/419 (35%)
		M1_APN_2	65..517	CDD:189008	165/507 (33%)
		ERAP1_C	591..886	CDD:288671	67/342 (20%)
erap1b	NP_956500.2	Peptidase_M1	46..453	CDD:279741	146/420 (35%)
		M1_APN_2	54..548	CDD:189008	165/507 (33%)
		ERAP1_C	615..932	CDD:288671	69/366 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170590545
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0308
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X67
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	7	6.850