DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31343 and CG6071

DIOPT Version :9

Sequence 1:	NP_732652.1	Gene:	CG31343 / 326133	FlyBaseID:	FBgn0051343	Length:	961	Species:	Drosophila melanogaster
Sequence 2:	NP_648488.1	Gene:	CG6071 / 39308	FlyBaseID:	FBgn0036186	Length:	962	Species:	Drosophila melanogaster

Alignment Length:	1010	Identity:	225/1010 - (22%)
Similarity:	391/1010 - (38%)	Gaps:	205/1010 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    63 EPESYNVELWTNVHNGD--TEFNGTVNIDIRVLNETS-------NITLH------YRQTS--NFE 110
            :|..||:.:.|.:.:.|  .:|.|.|:|||.....|.       |||:.      ||..|  ...
  Fly    23 KPLRYNLTILTRLGSEDEQNQFEGIVSIDIEATQPTRVIYLNSLNITISRQRTWIYRWASGRKIG 87

  Fly   111 ATIISRDVATPTAIPLTVTPELQREFLVLTQTTAGEAFGANTNWTITINYTG-IHRSDMGGFYIS 174
            |..|.|.:...:.|.:.:...|:          :||.:      |:.:.::| :.||...|::..
  Fly    88 ALQIKRIIKKTSLIKIVIELPLR----------SGEIY------TLNMLFSGNLDRSQQYGYFAG 136

  Fly   175 SYTDDDGEQHFLATTQFESTNARHAFPCYDEPARRANFTITIHHDPSYTAISNMPVNTAATSSGV 239
            .|  |...:.|.:.|:.|...|...|||:|:|..|..:.||:.||..|.|:||||.........:
  Fly   137 YY--DKTPRVFYSATRLEPDYAHTVFPCFDDPRFRTPYNITLVHDRKYVALSNMPPVEEKPYKEI 199

  Fly   240 -----TAFQTTPKMSTYLVAFIVSDFESTTGELNGIRQRVFSRKGKQDQQEWALWSGLLVESSLA 299
                 |.|..:|.::|..|.:.:...|           :|:|...... :...:||...:...||
  Fly   200 ENYVSTTFMGSPPLATQQVMWTLHQLE-----------KVYSGPAAAG-ENITVWSRPHLAEKLA 252

  Fly   300 ----------SYFGVPFALP---------KLDQAGIPDFSAGAMENWGLATYREQYMWWNKQNST 345
                      |.:...||.|         |:|...:|.::. .....|:..|.|..: .:.||..
  Fly   253 KVPEMTPNLFSKYETLFAYPLPKGADWGGKVDHVVLPRYTE-MYSGQGIMVYGEDIV-DSGQNGL 315

  Fly   346 INLKTNIANIIGHEYAHMWFGDLVSIKWWTYLWLKEGFATLFSYESNDIAFPLWDTYQIFHVNDY 410
            .:|:..:|.::    |..|.|.||:::.....:::.|   :..|.|..:.....:.|...|::..
  Fly   316 ESLQETLAELV----ARQWNGLLVNLEDSDEEYVRNG---INYYLSVQVMAMDKEAYNTTHLSKT 373

  Fly   411 N-SALLNDALASAVPMTHYVQTPSEISNRYNTFSYAKPASVLYMFKNAWTDKVFRTGLNKYLTKN 474
            . ..|.:|:||....:...|:     .:.:......|...:::|.|.|..||:|..||.::..:.
  Fly   374 RLDVLYHDSLAKVKSIATDVK-----ESGHQKLRKKKMCLLIHMLKVALGDKLFLKGLQEFFKRY 433

  Fly   475 QYTSCDEWDLFASFQESADE-----LGFTLPASVDDIFSSWSHQAGYPLLTVTRNYNAGTITITQ 534
            ..:|....:|:..||..|..     .|.:||.    :..||..|.|:|||||.|:.....:||||
  Fly   434 ANSSASSKELWEEFQRGARRSHQLPTGVSLPT----VMESWMKQPGFPLLTVQRDDAKQIVTITQ 494

  Fly   535 KRYVANKTDTNS-ATWYVPLNFATAN-----------KYDYRDTSATHYLLNVTETVISDVEASS 587
            .||.....|.:| ..|:||:.:...|           :.:.||.....::            |:.
  Fly   495 SRYYQKYLDNSSNDCWWVPVAYIVRNLTLPQVEWLGCQKNSRDILELSHI------------ANP 547

  Fly   588 DDWIIVNIQNSGYYRTLYDTQNYGLITAALKSQPWRFHPRNRAQLLYDTYIFVSTDRLSHSILLE 652
            :||:::|:..:...|..||:.|..||:.||:....:....:|.||:.|......:.||.:::.|.
  Fly   548 EDWLLINVDAAVPLRVFYDSYNLQLISEALRQDFTQIPELSRIQLVDDALSLSWSGRLPYNVTLN 612

  Fly   653 LLGYLTNEQQYAPWSTANTILTVYDRYLRGDDSYYNFQDFVKRLIDPIF--------------DK 703
            ::.||:||.....|.||...|......:|....:..|:.::::||:|.|              .:
  Fly   613 VISYLSNETSVLVWETALLNLEKLQSIMRMTTGFRIFKLYMQKLIEPAFKTTLNSLSTKARTGSE 677

  Fly   704 IGVN-------------------------------------------------EIPGEHYLNNYL 719
            |.:|                                                 |.|.....:..|
  Fly   678 IPINTKSPVTTESSGTTESPDTTESPDTAESPDTTESSNTTESPDTTESSDTTESPDTTKSDLSL 742

  Fly   720 RIVLVSLACQVGSDDCYNQSANKLSEYL--YNGTAIEATLKTQAYCAGLRSTTNEIYSRVQSDLL 782
            ..:|..||||....:|...:..:....:  .:.::|...::....|.|:|:.....:..|:....
  Fly   743 SAILYRLACQFEIKECLTDAQQRFQAAMDQKSSSSIPEEIREIVLCRGIRNGLEVHWIMVRDMFF 807

  Fly   783 SSSDSTDRSLFISSLGCSGSTSQLLDFLRLSLDTNNSLSYSERTSLLNSAYSRSEIGLTASLEFL 847
            .|.:..:||:.::||.|:.....:...|..:|| :..:..:...||| ||..||.:|.....:||
  Fly   808 ESENDKERSILLNSLSCTTEYWAMQKLLSWALD-SKKVPRTMTASLL-SAVLRSPLGYYVGKQFL 870

  Fly   848 ESNWEAYANLSDSAKPLDAALRGIATYVVSEKQKTRLNALVDVVEADGPSYINDDLSTTIDS--- 909
            ..:.:......|....|...:..::|       |...:||.|.:..:.||.:...||:|::|
  Fly   871 IDHSKEILRSKDVKLILTPFINAMST-------KAEFSALNDHLHRNLPSSMVSGLSSTLESGLD 928

  Fly   910 ----RITSNFAWLEVNRDPVLNWIEDSLKENGSPS 940
                |....|..|:..||..|    |...:|.|.|
  Fly   929 RVNWRNNLYFDLLKAIRDFTL----DDGPKNSSDS 959

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31343	NP_732652.1	Peptidase_M1	57..446	CDD:279741	93/425 (22%)
		M1_APN_2	65..517	CDD:189008	113/499 (23%)
		ERAP1_C	591..886	CDD:288671	69/359 (19%)
CG6071	NP_648488.1	GluZincin	25..477	CDD:301352	113/499 (23%)
CG6071	NP_648488.1	ERAP1_C	551..929	CDD:288671	78/386 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45462098
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0308
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	6	5.850