DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31343 and AgaP_AGAP003692

DIOPT Version :9

Sequence 1:	NP_732652.1	Gene:	CG31343 / 326133	FlyBaseID:	FBgn0051343	Length:	961	Species:	Drosophila melanogaster
Sequence 2:	XP_562562.2	Gene:	AgaP_AGAP003692 / 3290884	VectorBaseID:	AGAP003692	Length:	932	Species:	Anopheles gambiae

Alignment Length:	993	Identity:	293/993 - (29%)
Similarity:	466/993 - (46%)	Gaps:	144/993 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 LPLSLDDGQLETKGAALFATSRVDDNSAGNYRLPNTTEPESYNVELWTNVHNGD-TEFNGTVNID 89
            |||.|....:|.  ....|||| |.:....|.||..:||.:||  |:.::.|.| ..:||||.|.
Mosquito    13 LPLILASAPVEI--VEKVATSR-DAHDDSRYLLPKVSEPINYN--LFLDITNYDFYSYNGTVEIT 72

  Fly    90 IRVLNETSNITLHYRQTSNFEATIISRD---VATPTAIPLTVTPELQREFLVLTQTTAGEAFGAN 151
            .|...:.::..|      |.:..:|:.:   |..|....:.|...:..|..........:.....
Mosquito    73 FRYTGDQNHFYL------NSDGLVIATESIKVTGPDGTDVPVANVIYMEEFEQIYFGFRDRLQTR 131

  Fly   152 TNWTITINYTGIHRSDMGGFYISSYTDDDGEQHFLATTQFESTNARHAFPCYDEPARRANFTITI 216
            ..:.|.|::.....:::.|.|.|||...: ...:||||.||||.||..|||||||:.:|.|.:.|
Mosquito   132 EQYKIAISFLNNIGTELKGLYRSSYMAGN-TTRYLATTHFESTYARSVFPCYDEPSYKATFNVKI 195

  Fly   217 HHDPSYTAISNMPVNTAATSSGV--TAFQTTPKMSTYLVAFIVSDFESTTGELNGIRQRVFSRKG 279
            .|...|.|:||||...:.|....  |.|.|||.|||||:||::|||::.:.|.:  |.|||:.:.
Mosquito   196 RHRSEYRALSNMPAINSVTVGDYTETTFDTTPLMSTYLLAFVISDFKTLSHESD--RFRVFAAES 258

  Fly   280 KQDQQEWALWSGLLVES--SLASYFGVPFALPKLDQAGIPDFSAGAMENWGLATYREQYMWWNKQ 342
            |.....:||  ..|..|  :|.::||..:.|||:|...||||:.||||||||.|:||||:.:.:.
Mosquito   259 KVAHTGYAL--EFLGNSLRTLENFFGRQYQLPKVDLIAIPDFAMGAMENWGLITFREQYLIYEEG 321

  Fly   343 NSTINLKTNIANIIGHEYAHMWFGDLVSIKWWTYLWLKEGFATLFSYESNDIAFPLWDTYQIFHV 407
            .:|...|.|||::|.||..|||||:.|:.:|||||||.||||..|.|.
Mosquito   322 VTTARTKQNIADLITHELTHMWFGNEVTPEWWTYLWLSEGFARYFEYY----------------- 369

  Fly   408 NDYNSALLNDALASAVPMTH-YVQTPSEISNRYNTFSYAKP---ASVLYMFKNAWTDKVFRTGLN 468
              ..|.::|......|.:.| :..|         |||.:.|   .|...:..|......||..||
Mosquito   370 --ITSQVMNQIFVKYVIVPHVFCST---------TFSSSLPGTSGSKFIVNNNVIGFDTFRQSLN 423

  Fly   469 KYLTKNQYTSCDEWDLFASFQE--SADELGFTLPASVDDIFSSWSHQAGYPLLTVTRNYNAGTIT 531
            .||....|.:.....|:.|.::  :.|     ||||::.||.||::..|||::||:.:....|:|
Mosquito   424 DYLRSRSYLTTRPQYLYTSIEKFRTVD-----LPASIELIFESWANTPGYPVVTVSIDRTKRTLT 483

  Fly   532 ITQKRY-VANKTDT--NSATWYVPLNFAT--ANKYDYRDTSATHYLLNVTETVISDVEASSDDWI 591
            .:|||: :.|:.||  .:..:|:|:|:.|  ....::.||:.|.:|.....|....:||.. :|:
Mosquito   484 ASQKRFWMPNELDTPPQNMLFYIPVNYGTNVPTSTNFEDTTPTFWLTPQDPTATVSLEAGV-EWV 547

  Fly   592 IVNIQNSGYYRTLYDTQNYGLITAALKSQPWRFHPR----NRAQLLYDTYIFVSTDRLSHSILLE 652
            :||.|.:||||..||.:::..:...|.|:  :|..:    |||||:.|.........:.:.:.|.
Mosquito   548 VVNKQQTGYYRVNYDDESWHKLIEVLNSE--QFEDQLPVINRAQLVDDVANLARAGEVGYDVALS 610

  Fly   653 LLGYLTNEQQYAPWSTANTILTVYDRYLRGDDSYYNFQDFVKRLIDPIFDKI----GVNEIPGEH 713
            |:.||..|.:|.||:||...|...||.....:.|..|:.|::.:...:::.|    .:::|...|
Mosquito   611 LMQYLERETEYIPWATAYNALLHLDRMFSSHEEYSRFETFLRTITGCMYENILLTGPMDQISRLH 675

  Fly   714 YLNNYLRIVLVSLACQVGSDDCYNQS---ANKLSEYLYNGTAIEATLKTQAYCAGLR---STTNE 772
            ..|.      |.|||..|...|.:.:   |||..:  .:...|...::...:||..:   :|.|
Mosquito   676 RGNT------VYLACYSGVKKCLDDAHALANKAVQ--DSSFTIPEEVQASVFCALHKYPSATLN- 731

  Fly   773 IYSRVQSDL----LSSSDSTDR----SLFISSLGCSGSTSQLLDFLRLSLDTNNSLSYSERTSLL 829
                ||:||    ::|::|.:.    :.|::|:||:.:.:.:..:|.||     :.:|   ..|.
Mosquito   732 ----VQTDLFEKYVTSANSPEDLDMINRFLASVGCARNETIMEYYLTLS-----AYNY---PGLP 784

  Fly   830 NSAYSRSEIGL----------TASLEFLESNWEAYANLSDSAKPLDAALRGIATYVVSEKQKTRL 884
            .:|..||:|.|          .|:|::|..::.....|..|..|:...|        ..:..|||
Mosquito   785 VTAGQRSQIYLGLINGSPGTRQAALQYLYEHFSTVTYLLTSVTPIFTEL--------GNRINTRL 841

  Fly   885 --NALVDVVEADGPSYINDDLSTTIDSRIT---SNFAWLEVNRDPVLNWIEDSLKEN------GS 938
              ..|.::|:..| ..:........|:.:.   .|..|:|.:.:.:.:|:.:...|.      |.
Mosquito   842 QHEVLKNIVDEYG-HMLTTAAKAAADAALVKAEQNIRWIEKHAESITSWLVEQDYEGTTAQPPGG 905

  Fly   939 PSLTSSITTILVSAMALL 956
            .::..|:...:....|:|
Mosquito   906 GAVAYSVGIAVAFGCAIL 923

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31343	NP_732652.1	Peptidase_M1	57..446	CDD:279741	141/397 (36%)
		M1_APN_2	65..517	CDD:189008	159/465 (34%)
		ERAP1_C	591..886	CDD:288671	82/328 (25%)
AgaP_AGAP003692	XP_562562.2	Peptidase_M1	42..374	CDD:279741	134/363 (37%)
		M1_APN_2	49..469	CDD:189008	159/465 (34%)
		ERAP1_C	547..>819	CDD:288671	75/294 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0308
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X67
TreeFam	0	0.000	Not matched by this tool.
	5	4.820