DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31343 and lnpep

DIOPT Version :9

Sequence 1:	NP_732652.1	Gene:	CG31343 / 326133	FlyBaseID:	FBgn0051343	Length:	961	Species:	Drosophila melanogaster
Sequence 2:	XP_021331684.1	Gene:	lnpep / 322814	ZFINID:	ZDB-GENE-030131-1534	Length:	1026	Species:	Danio rerio

Alignment Length:	904	Identity:	247/904 - (27%)
Similarity:	422/904 - (46%)	Gaps:	85/904 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    57 RLPNTTEPESYNVELWTNVHNGDTEFNGTVNIDIRVLNETSNITLHYRQTSNFEATIISRDVATP 121
            |||.:..|..||:.|..::::  ..|.|.|:|.:.|::||.||.||....:..:.|...::...
Zfish   177 RLPVSVHPVHYNISLHPDLNS--MTFQGNVSIVVLVMHETKNIILHSSDMNIIKVTFDDKEYRF- 238

  Fly   122 TAIPLTVTPELQREFLVLTQTTAGEAFGANTNWTITINYTGIHRSDMGGFYISSYTDDDGEQHFL 186
                |...|..|...........|:       :.:..:|.....:...|||.|||.|..|.:..|
Zfish   239 ----LEYKPWQQIAIKFPEDLKKGQ-------YVLKFSYKANLSNSYDGFYNSSYVDTAGTKRVL 292

  Fly   187 ATTQFESTNARHAFPCYDEPARRANFTITIHHDPSYTAISNMP--VNTAATSSGV--TAFQTTPK 247
            |.||||...||.||||:||||.::.|.:.:..:..|.::||||  ..|....:|:  ..|:::.|
Zfish   293 AATQFEPLAARKAFPCFDEPAFKSTFVVKMTREAKYISLSNMPKIKTTDLNENGLQEDEFESSVK 357

  Fly   248 MSTYLVAFIVSDFESTTGELNGIRQRVFSRKGKQDQQEWALWSGLLVESSLASYFGVPFALPKLD 312
            ||||||||||::|.|.:..::.....|::...|:||..:||.:...:.....::|.:.:.|.|||
Zfish   358 MSTYLVAFIVAEFSSHSKNVSKTTVSVYAVPDKKDQVHYALETACKLLKFYNTFFEIEYPLSKLD 422

  Fly   313 QAGIPDFSAGAMENWGLATYREQYMWWNKQNSTINLKTNIANIIGHEYAHMWFGDLVSIKWWTYL 377
            ...||||.|||||||||.|:||..:....|:|..: |..:.::|.||.||.|||:||:::||..|
Zfish   423 LVAIPDFLAGAMENWGLITFRETTLLVGNQSSRFD-KQLVTSVIAHELAHQWFGNLVTMRWWNDL 486

  Fly   378 WLKEGFATLFSYESNDIAFPLWDTYQIFHVNDYNSALLNDALASAVPMTHYVQTPSEISNRYNTF 442
            ||.|||||...|.|.:..||..| ..|..:|....||..|||.|:.|::.:|.||.::...:::.
Zfish   487 WLNEGFATYMQYMSIENVFPDLD-IDIEFLNVRFKALAKDALNSSHPVSTFVSTPEQVEEMFDSV 550

  Fly   443 SYAKPASVLYMFKNAWTDKVFRTGLNKYLTKNQYTSCDEWDLFASFQESADELGFTLPASVDDIF 507
            ||.|.||:|.|......|..|..|:.:||.....::.:..||:.|..:.:.:     ..:|.::.
Zfish   551 SYEKGASILLMLNATLRDGEFHKGVIEYLQNYNLSNTESKDLWNSLSQVSKQ-----SLNVSEMM 610

  Fly   508 SSWSHQAGYPLLTVTRNYNAGTITITQKRYVANK---TDTNSATWYVPLNFATANKYDYRDTSAT 569
            ::|:...|:||:||.|  |...:|::|:.::.|.   || :|:.|::||.:...:....|.....
Zfish   611 NTWTVHKGFPLVTVKR--NGPQVTLSQEHFLLNAENGTD-DSSLWHIPLTYVNDSCSVLRSCKQV 672

  Fly   570 HYLLNVTETVISDVEASSD-----DWIIVNIQNSGYYRTLYDTQNYGLITAALKSQPWRFHPRNR 629
            .:|        .|.||:..     .|:..|.::.|:|...||.|.:..:.:|||.........::
Zfish   673 FHL--------KDKEATLQLPGQVKWLKFNFRSDGFYIVHYDEQGWSDLISALKVDVNVLPSEDK 729

  Fly   630 AQLLYDTYIFVSTDRLSHSILLELLGYLTNEQQYAPWSTANTILTVYDRYL--RGDDSYYNFQDF 692
            |.|:.:.:......::|...:|.|:.|:.||.:.||.:.|.:.|....|.|  |.|   .|....
Zfish   730 AALINNIFALSRLGKVSFRQVLNLMDYIRNETETAPLTEALSQLGQIYRLLDKRSD---LNLASS 791

  Fly   693 VKRLIDPIFDKI----------GVNEIPGEHYLNNYLRIVLVSLACQVGSDDCYNQSANKLSEYL 747
            :...|:..|..:          .|:::.        ||..|:..||.:...:|..|:.....::|
Zfish   792 MTTYIESHFGSLMESQSWEVETSVSKMT--------LRSALLETACALNRPNCTTQARRLFDQWL 848

  Fly   748 YNGTAIEATLKTQAYCAGLRSTTNEIYSRVQSDLLSSSDSTDRSLFISSLGCSGSTSQLLDFLRL 812
            .:...::...........:.:.|:|.:|::......|...|::...:.:|..:....:::..|:.
Zfish   849 ASNKTLQIPSDLMRTVFKVAAKTDEGWSKLLGSYKHSIYDTEKRKMLEALASTQDVRKIIWVLQK 913

  Fly   813 SLDTNNSLSYSERTSLLNSAYSRSEIGLTASLEFLESNWEAYANLSDSAKPLDA-ALRGIATYVV 876
            |||  .|...::...|:.....|...|...:.:|::.|||...    ...|:.: |::.|.|...
Zfish   914 SLD--GSEIQNQEFPLVIHTVCRDFAGYLYAWDFMKENWEKIT----QKFPIGSFAIQSIITSTT 972

  Fly   877 SE-KQKTRLNALVDVVEADGPS-----YINDDLSTTIDSRITSNFAWLEVNRDPVLNWI 929
            |: ..||.|..:.:...:.|..     .:.:.:.|     |..|..|:|.|.:.:.:|:
Zfish   973 SQFSTKTHLAEVQNFFSSLGAKGSQMRIVQEAIET-----IKHNMRWMEKNLNTLQSWL 1026

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31343	NP_732652.1	Peptidase_M1	57..446	CDD:279741	139/392 (35%)
		M1_APN_2	65..517	CDD:189008	151/455 (33%)
		ERAP1_C	591..886	CDD:288671	63/308 (20%)
lnpep	XP_021331684.1	M1_APN_2	185..620	CDD:189008	151/455 (33%)
lnpep	XP_021331684.1	ERAP1_C	690..1009	CDD:314669	66/340 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170590560
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X67
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.950