DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31343 and anpepb

DIOPT Version :9

Sequence 1:	NP_732652.1	Gene:	CG31343 / 326133	FlyBaseID:	FBgn0051343	Length:	961	Species:	Drosophila melanogaster
Sequence 2:	NP_001082794.1	Gene:	anpepb / 322533	ZFINID:	ZDB-GENE-030131-1253	Length:	965	Species:	Danio rerio

Alignment Length:	949	Identity:	292/949 - (30%)
Similarity:	467/949 - (49%)	Gaps:	86/949 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 TKGAA--LFATSRVDDNSAGN-----YRLPNTTEPESYNVELWTNVH---NGDTEFNGTVNIDIR 91
            |||..  :.||:.:......|     :|||.|..||:|.|.||..:.   .|...|.|..::..|
Zfish    51 TKGPTTNVPATTNIPTTVPSNEPWDQWRLPQTLSPETYKVTLWPRLQKNAEGLYIFTGDSSVVFR 115

  Fly    92 VLNETSNITLHYRQTSNFEATIISR--DVATPTAIPLTVTPELQREFLVL-TQTTAGEAFGANTN 153
            .:..|..|.:|..:.:..::|.:..  ....|..:...:.|:.|...:.| .:.||||::...|
Zfish   116 CVENTDLILIHSNKLTIKDSTTLKALGGNPAPNIVSTKMYPKTQYMAIWLDRELTAGESYELYT- 179

  Fly   154 WTITINYTGIHRSDMGGFYISSYTDDDGEQHFLATTQFESTNARHAFPCYDEPARRANFTITIHH 218
                 .:.|....|:||||.|.|.|::|....:||||.::|:||.||||:||||.:|.|.|.:.|
Zfish   180 -----EFVGELSDDLGGFYRSEYYDENGVLKVVATTQMQATDARKAFPCFDEPAMKAVFNIVLLH 239

  Fly   219 DPSYTAISN------MPVNTAATSSGVTAFQTTPKMSTYLVAFIVSDFESTTGELNGIRQRVFSR 277
            ||...|:||      :||.....|...|.|..|.||||||:|||||:|.....:|:.::.|:|:|
Zfish   240 DPGTVALSNGVVIEEIPVTVDGISLTKTTFAPTEKMSTYLLAFIVSEFTYIEQKLDDLQIRIFAR 304

  Fly   278 KGKQD--QQEWALWSGLLVESSLASYFGVPFALPKLDQAGIPDFSAGAMENWGLATYREQYMWWN 340
            |...|  |.|:||.....:......|:...:.|||.||..:|||:|||||||||.||||..:.::
Zfish   305 KEAIDANQGEYALSVTGKILRFFEEYYNSSYPLPKSDQIALPDFNAGAMENWGLITYRETALLYD 369

  Fly   341 KQNSTINLKTNIANIIGHEYAHMWFGDLVSIKWWTYLWLKEGFATLFSYESNDIAFPLWDTYQIF 405
            ::.|:...|..:..:|.||.||.|||:||:|:||..|||.||||:...|...|.|.|||:...:.
Zfish   370 EEMSSNGNKERVVTVIAHELAHQWFGNLVTIRWWNDLWLNEGFASYVEYLGADEAEPLWNIKDLI 434

  Fly   406 HVNDYNSALLNDALASAVPMT---HYVQTPSEISNRYNTFSYAKPASVLYMFKNAWTDKVFRTGL 467
            .:||.:.....|||||:.|::   ..||.|.:||..::|.||:|.||||.|..|..::.||..||
Zfish   435 VLNDVHRVFAIDALASSHPLSSKEEDVQRPEQISEVFDTISYSKGASVLRMLSNFLSEDVFTQGL 499

  Fly   468 NKYLTKNQYTSCDEWDLFASFQESADELGFTLPASVDDIFSSWSHQAGYPLLTVTRNYNAGTITI 532
            ..||...::.:....||:...|.:.||.|..||.||.||...|..|.|:|::|:    |..|..|
Zfish   500 RTYLEHFKFNNTVYTDLWDHLQMAVDETGTELPRSVKDIMDRWVLQMGFPVVTI----NTVTGQI 560

  Fly   533 TQKRYVAN---KTDTN--SATWYVPLNFATANKYDYRDTSATHYLLNVTETVISDVEASSDDWII 592
            :|:.::.:   |.:.:  :..|:||:.: |.|     :.....|.|....|...|::.::::|::
Zfish   561 SQEHFLLDPETKPEPSEFNYEWFVPITW-TKN-----EAIKPQYWLLQKNTQFDDMKTNANEWVL 619

  Fly   593 VNIQNSGYYRTLYDTQNYGLITAALKSQPWRFHPRNRAQLLYDTYIFVSTDRLSHSILLELLGYL 657
            .||...||||..||.||:..:..||::........|||||:.|.:.......:..::.|....:|
Zfish   620 ANINTVGYYRVNYDEQNWERLLNALQTSRESIPVINRAQLIDDAFNLAKAGIIKTTLALRTTEFL 684

  Fly   658 TNEQQYAPWSTANTILTVYDRYLRGDDS--YYNFQDFVKRLIDPIF-------DKIGVNEIPGEH 713
            ..|.:|.||.:|...|..:  ||..|.|  |.:.|.::::.:.|:|       |..||   |..|
Zfish   685 DVETEYMPWQSALNNLDYF--YLMFDRSEVYGHMQAYIRKQVTPLFEYFTELTDWQGV---PDNH 744

  Fly   714 YLNNYLRIVLVSLACQVGSDDCYNQSANKLSEYLYNG--TAIEATLKTQAYCAGLRSTTNEIYSR 776
             ...|.::..:.:||.:|..:|.:...:...|::.|.  ..|.|.|::..||:.:.:...|.:..
Zfish   745 -TEQYNQVNALRVACSIGLKNCTDLVTSWFGEWMNNEDVNPIHANLRSTVYCSAIAAGGAEEWEF 808

  Fly   777 VQSDLLSSSDSTDRSLFISSLGCSGSTSQLLDFLRLSLDTNNSLSYSERTSLLNSAYSRSEIGLT 841
            .......:|.::::....:::.|:.....|..:|..:||. |.:...:.||.:.|..|... |.:
Zfish   809 AWKMFEKTSVASEKDKLRAAMACATQPWLLNRYLEYTLDA-NKIRKQDATSTIVSIASNVG-GQS 871

  Fly   842 ASLEFLESNWE-----------AYANLSDSAKPLDAALRGIATYVVSEKQKTRLNALVDVVEADG 895
            .:.:|:.:|||           :::||          :.|:.....:|.:..:|....:..|..|
Zfish   872 LAWDFVRANWEYIFNQYGGGSFSFSNL----------INGVTKRFSTEFELKQLMQFKEDNEHIG 926

  Fly   896 PSYINDDLSTTIDSRITSNFAWLEVNRDPVLNWIEDSLK 934
            ....:..:..:|: |..:|..|:|.|:..||.|.:|..|
Zfish   927 FGSGSLAIQQSIE-RTKANIKWVEQNKADVLQWFKDQSK 964

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31343	NP_732652.1	Peptidase_M1	57..446	CDD:279741	155/405 (38%)
		M1_APN_2	65..517	CDD:189008	178/468 (38%)
		ERAP1_C	591..886	CDD:288671	73/316 (23%)
anpepb	NP_001082794.1	Peptidase_M1	78..479	CDD:279741	155/406 (38%)
		M1_APN_2	88..549	CDD:189008	177/466 (38%)
		ERAP1_C	618..940	CDD:288671	76/340 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170590593
Domainoid	1	1.000	105	1.000	Domainoid score	I6573
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X67
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	8	7.950