Protein Alignment CG31343 and Lta4h

DIOPT Version :9

• Sequence 1: NP_732652.1
• Gene: CG31343 / 326133
• FlyBaseID: FBgn0051343
• Length: 961
• Species: Drosophila melanogaster
• Sequence 2: NP_001025202.1
• Gene: Lta4h / 299732
• RGDID: 1311333
• Length: 611
• Species: Rattus norvegicus
• Alignment Length: 541
• Identity: 130/541 - (24%)
• Similarity: 204/541 - (37%)
• Gaps: 117/541 - (21%)

  Fly   101 LHYRQTSNFEATIISRDVATPTAIPLTV-------------TPELQREFLVL----TQTTAGE-- 146
            ||.|.:.:|     :|...|.|| .|||             |.:|..|.:|:    .:.|.||
  Rat    22 LHLRCSVDF-----ARRALTGTA-ALTVQSQEDNLRSLTLDTKDLTIEKVVINGQEVKYTLGESQ 80

  Fly   147 -------------AFGANTNWTITINYTGIHRSDMGGFYISSYTDDDGEQHFLATTQFESTNARH 198
                         |...|....|.|::....:|....:.....|  .|:||....:|.::.:.|.
  Rat    81 GYKGSPMEISLPIALSKNQEVVIEISFETSPKSSALQWLTPEQT--SGKQHPYLFSQCQAIHCRA 143

  Fly   199 AFPCYDEPARRANFTITIHHDPSYTAISNMPVNTAATSSGVT---------------AFQTTPKM 248
            ..||.|.|:.:.          :|||..::|....|..|.:.               .|.....:
  Rat   144 ILPCQDTPSVKL----------TYTAEVSVPKELVALMSAIRDGEAPDPEDPSRKIYRFNQRVPI 198

  Fly   249 STYLVAFIVSDFESTTGELNGIRQRVFSRKGKQDQQEWALWSGLLVESSL--ASYFGVPFALPKL 311
            ..||:|.:|...||   ...|.|..|:|.|   :|.|.:.:.....||.|  |...|.|:...:.
  Rat   199 PCYLIALVVGALES---RQIGPRTLVWSEK---EQVEKSAYEFSETESMLKIAEDLGGPYVWGQY 257

  Fly   312 DQAGI-PDFSAGAMENWGLATYREQYMWWNKQNSTINLKTNIANIIGHEYAHMWFGDLVSIKWWT 375
            |...: |.|..|.|||..|.......:..:|         :::|:|.||.:|.|.|:||:.|.|.
  Rat   258 DLLVLPPSFPYGGMENPCLTFVTPTLLAGDK---------SLSNVIAHEISHSWTGNLVTNKTWD 313

  Fly   376 YLWLKEGFATLFSYESNDIAFPLW-DTYQIFHVNDYNSALLN--DALASAVPMTHYVQTPSEISN 437
            :.||.||...   |....|...|: :.::.||.......|.|  .....:.|.|..|....::..
  Rat   314 HFWLNEGHTV---YLERHICGRLFGEKFRHFHALGGWGELQNTIKTFGESHPFTKLVVDLKDVDP 375

  Fly   438 --RYNTFSYAKPASVL-YMFKNAWTDKVFRTGLNKYLTKNQYTS--CDEWD--LFASFQESADEL 495
              .|::..|.|..::| |:.:.....:||...|..|:.|..|.|  .|:|.  |:|.|::..|.|
  Rat   376 DVAYSSIPYEKGFALLFYLEQLLGGPEVFLGFLKAYVEKFSYQSVTTDDWKSFLYAHFKDKVDLL 440

  Fly   496 GFTLPASVDDIFSSWSHQAGYPLLTVTRNYNA----GTITITQKRYVANKTDTNSATWYVPLNFA 556
            .     .||  :::|.:..|.|  .|..||:.    ..|.::|:...|.:.|.||        |:
  Rat   441 N-----QVD--WNAWLYAPGLP--PVKPNYDVTLTNACIALSQRWVTAKEEDLNS--------FS 488

  Fly   557 TANKYDYRDTSATHYLLNVTE 577
            ..:..|........:|..|.:
  Rat   489 IEDLKDLSSHQLNEFLAQVLQ 509

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG31343	NP_732652.1	Peptidase_M1	57..446	CDD:279741	95/399 (24%)
		M1_APN_2	65..517	CDD:189008	116/475 (24%)
		ERAP1_C	591..886	CDD:288671
Lta4h	NP_001025202.1	leuko_A4_hydro	6..608	CDD:274120	130/541 (24%)
		Substrate binding. /evidence=ECO:0000250|UniProtKB:P09960	135..137		1/1 (100%)
		Substrate binding. /evidence=ECO:0000250|UniProtKB:P09960	267..272		1/4 (25%)
		Substrate binding. /evidence=ECO:0000250|UniProtKB:P09960	564..566

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0308
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900