DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31343 and TRHDE

DIOPT Version :9

Sequence 1:	NP_732652.1	Gene:	CG31343 / 326133	FlyBaseID:	FBgn0051343	Length:	961	Species:	Drosophila melanogaster
Sequence 2:	NP_037513.2	Gene:	TRHDE / 29953	HGNCID:	30748	Length:	1069	Species:	Homo sapiens

Alignment Length:	1003	Identity:	276/1003 - (27%)
Similarity:	478/1003 - (47%)	Gaps:	104/1003 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 SLILLLAVCSLQARLILPLSLDD-GQLETKGA--------------ALFATSRVDDNS------- 52
            ||:.||||..|  .::|.|..|: |...|.||              :|..::|.:.::
Human    92 SLVALLAVTML--AVLLSLRFDECGASATPGADGGPSGFPERGGNGSLPGSARRNHHAGGDSWQP 154

  Fly    53 -AGNYRLPNTT-------------------------EPESYNVELWTNVHNGDTEFNGTVNIDIR 91
             ||....|.||                         :|..||:.|...:.|  ..|:|.||::|.
Human   155 EAGGVASPGTTSAQPPSEEEREPWEPWTQLRLSGHLKPLHYNLMLTAFMEN--FTFSGEVNVEIA 217

  Fly    92 VLNETSNITLHYRQTSNFEATIISRDVATPTAIPLT---VTPELQREFLVLTQTTAGEAFGANTN 153
            ..|.|..:.||..:.: .|...::.|.|. .|:|:.   :.|:.|...:||.:|     ..|..|
Human   218 CRNATRYVVLHASRVA-VEKVQLAEDRAF-GAVPVAGFFLYPQTQVLVVVLNRT-----LDAQRN 275

  Fly   154 WTITINYTGIHRSDMGGFYISSYTDDDGEQHFLATTQFESTNARHAFPCYDEPARRANFTITIHH 218
            :.:.|.|..:..:::.||:.|||. ..||:.||..|||..|:||.||||:|||..:|.|.|:|.|
Human   276 YNLKIIYNALIENELLGFFRSSYV-LHGERRFLGVTQFSPTHARKAFPCFDEPIYKATFKISIKH 339

  Fly   219 DPSYTAISNMPVNTAA--TSSGVT-AFQTTPKMSTYLVAFIVSDF---ESTTGELNGIRQRVFSR 277
            ..:|.::|||||.|:.  ....|| .|..||.||||.:|:.:.:|   |:||  .:|:..|:::|
Human   340 QATYLSLSNMPVETSVFEEDGWVTDHFSQTPLMSTYYLAWAICNFTYRETTT--KSGVVVRLYAR 402

  Fly   278 KG--KQDQQEWALWSGLLVESSLASYFGVPFALPKLDQAGIPDFSAGAMENWGLATYREQYMWWN 340
            ..  ::...::||.....:......||.||::|||||...:|.....|||||||:.:.||.:..:
Human   403 PDAIRRGSGDYALHITKRLIEFYEDYFKVPYSLPKLDLLAVPKHPYAAMENWGLSIFVEQRILLD 467

  Fly   341 KQNSTINLKTNIANIIGHEYAHMWFGDLVSIKWWTYLWLKEGFATLFSYESNDIAFPLWD-TYQI 404
            ...|:|:...::..:|.||..|.||||||:..||..:|||||||..|.:...|..:|.|: ..|.
Human   468 PSVSSISYLLDVTMVIVHEICHQWFGDLVTPVWWEDVWLKEGFAHYFEFVGTDYLYPGWNMEKQR 532

  Fly   405 FHVNDYNSALLNDALASAVPMTHYVQTPSEISNRYNTFSYAKPASVLYMFKNAWTDKVFRTGLNK 469
            |..:..:..:|.|.|||:.|::..|...::|...::..:|.|.|:::.|..|.....||:.||..
Human   533 FLTDVLHEVMLLDGLASSHPVSQEVLQATDIDRVFDWIAYKKGAALIRMLANFMGHSVFQRGLQD 597

  Fly   470 YLTKNQYTSCDEWDLFASFQESADELGFTLPASVDDIFSSWSHQAGYPLLTVTRNYNA-GTITIT 533
            |||.::|.:....||:.:..|:....|..:  ::.::...|:.|.|||::|:..|..| ..|.||
Human   598 YLTIHKYGNAARNDLWNTLSEALKRNGKYV--NIQEVMDQWTLQMGYPVITILGNTTAENRIIIT 660

  Fly   534 QKRYV--------ANKTDTNSATWYVPLNFATANKYDYRDTSATHYLLNVTE-TVISDVEASSDD 589
            |:.::        |.|...||..|.:||.....|: .:..:.|..::.|.:| ..|:.::..|
Human   661 QQHFIYDISAKTKALKLQNNSYLWQIPLTIVVGNR-SHVSSEAIIWVSNKSEHHRITYLDKGS-- 722

  Fly   590 WIIVNIQNSGYYRTLYDTQNYGLITAALKSQPWRFHPRNRAQLLYDTYIFVSTDRLSHSILLELL 654
            |::.||..:||:|..||.:|:.|:...|..........|||.|:.|.:.......|..:|.||::
Human   723 WLLGNINQTGYFRVNYDLRNWRLLIDQLIRNHEVLSVSNRAGLIDDAFSLARAGYLPQNIPLEII 787

  Fly   655 GYLTNEQQYAPWSTANTILTVYDRYLRGDDSYYNFQDFVKRLIDPIFDKIG--VNEIPGE----H 713
            .||:.|:.:.||..|:..|...|:.|...::|..|.:::.:.:...:.|:|  .|...|.    .
Human   788 RYLSEEKDFLPWHAASRALYPLDKLLDRMENYNIFNEYILKQVATTYIKLGWPKNNFNGSLVQAS 852

  Fly   714 YLNNYLRIVLVSLACQVGSDDCYNQSANKLSEYL-YNGTAIEATLKTQAYCAGLRSTTNEIYSRV 777
            |.:..||..::.|||..|:..|:.|::..:|::: .|...|...::...||.|:.....:::..:
Human   853 YQHEELRREVIMLACSFGNKHCHQQASTLISDWISSNRNRIPLNVRDIVYCTGVSLLDEDVWEFI 917

  Fly   778 QSDLLSSSDSTDRSLFISSLGCSGSTSQLLDFLRLSLDTNNSLSYSERTSLLNSAYSRSEIGLTA 842
            .....|::..:::.:.:.:|.||...:.|...|.|||::...|.......:::.|  |:..|...
Human   918 WMKFHSTTAVSEKKILLEALTCSDDRNLLNRLLNLSLNSEVVLDQDAIDVIIHVA--RNPHGRDL 980

  Fly   843 SLEFLESNWEAYANLSDSAKPLDAAL-RGIATYVVSEKQKTRLNALVDVVEADGPSYINDDLSTT 906
            :.:|....|:........|..:::.| .|:..::.:|.:...|...:.  ..||.:..:  .|..
Human   981 AWKFFRDKWKILNTRYGEALFMNSKLISGVTEFLNTEGELKELKNFMK--NYDGVAAAS--FSRA 1041

  Fly   907 IDSRITSNFAWLEVNRDPVLNWIEDSLK 934
            ::: :.:|..|..:.:|.:..|:..:|:
Human  1042 VET-VEANVRWKMLYQDELFQWLGKALR 1068

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31343	NP_732652.1	Peptidase_M1	57..446	CDD:279741	139/425 (33%)
		M1_APN_2	65..517	CDD:189008	154/463 (33%)
		ERAP1_C	591..886	CDD:288671	69/302 (23%)
TRHDE	NP_037513.2	M1_APN-Q_like	193..638	CDD:341064	152/458 (33%)
TRHDE	NP_037513.2	ERAP1_C	723..1047	CDD:403137	73/330 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165155382
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0308
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X67
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.850