DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31343 and ANPEP

DIOPT Version :9

Sequence 1:	NP_732652.1	Gene:	CG31343 / 326133	FlyBaseID:	FBgn0051343	Length:	961	Species:	Drosophila melanogaster
Sequence 2:	NP_001141.2	Gene:	ANPEP / 290	HGNCID:	500	Length:	967	Species:	Homo sapiens

Alignment Length:	1017	Identity:	291/1017 - (28%)
Similarity:	484/1017 - (47%)	Gaps:	133/1017 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MARWLLNSFSL----ILL--LAVCSLQARLILPLSLDDGQLETKGA----------ALFATSR-- 47
            ||:....|.||    |||  .|||:     |:.||:...|.:.|.|          :..||:.
Human     1 MAKGFYISKSLGILGILLGVAAVCT-----IIALSVVYSQEKNKNANSSPVASTTPSASATTNPA 60

  Fly    48 ----VDDNSAGN-YRLPNTTEPESYNVEL---WTNVHNGDTEFNGTVNIDIRVLNETSNITLHYR 104
                :|.:.|.| ||||||.:|:||.|.|   .|....|...|.|:..:.......|..|.:|.:
Human    61 SATTLDQSKAWNRYRLPNTLKPDSYRVTLRPYLTPNDRGLYVFKGSSTVRFTCKEATDVIIIHSK 125

  Fly   105 QTSNFEAT----IISRDV--ATPTAIPLTVTPELQREFLVLTQTTAGEAFGA---NTNWTITINY 160
            :. |:..:    ::.|.|  :.|..|..|...| ..|:||:      ...|:   ::.:.:...:
Human   126 KL-NYTLSQGHRVVLRGVGGSQPPDIDKTELVE-PTEYLVV------HLKGSLVKDSQYEMDSEF 182

  Fly   161 TGIHRSDMGGFYISSYTDDDGEQHFLATTQFESTNARHAFPCYDEPARRANFTITIHHDPSYTAI 225
            .|....|:.|||.|.|.:.: .:..:||||.::.:||.:|||:||||.:|.|.||:.|....||:
Human   183 EGELADDLAGFYRSEYMEGN-VRKVVATTQMQAADARKSFPCFDEPAMKAEFNITLIHPKDLTAL 246

  Fly   226 SNMPVNTAAT------SSGVTAFQTTPKMSTYLVAFIVSDFESTTGEL-NGIRQRVFSRKG--KQ 281
            |||.....:|      :..||.|.|||||||||:|||||:|:....:. ||:..|:::|..  ..
Human   247 SNMLPKGPSTPLPEDPNWNVTEFHTTPKMSTYLLAFIVSEFDYVEKQASNGVLIRIWARPSAIAA 311

  Fly   282 DQQEWALWSGLLVESSLASYFGVPFALPKLDQAGIPDFSAGAMENWGLATYREQYMWWNKQNSTI 346
            ...::||.....:.:..|.::..|:.|||.||.|:|||:|||||||||.||||..:.::..:|:.
Human   312 GHGDYALNVTGPILNFFAGHYDTPYPLPKSDQIGLPDFNAGAMENWGLVTYRENSLLFDPLSSSS 376

  Fly   347 NLKTNIANIIGHEYAHMWFGDLVSIKWWTYLWLKEGFATLFSYESNDIAFPLWDTYQIFHVNDYN 411
            :.|..:..:|.||.||.|||:||:|:||..|||.||||:...|...|.|.|.|:...:..:||..
Human   377 SNKERVVTVIAHELAHQWFGNLVTIEWWNDLWLNEGFASYVEYLGADYAEPTWNLKDLMVLNDVY 441

  Fly   412 SALLNDALASAVPMT---HYVQTPSEISNRYNTFSYAKPASVLYMFKNAWTDKVFRTGLNKYLTK 473
            ..:..|||||:.|::   ..:.||::||..::..||:|.||||.|..:..::.||:.||..||..
Human   442 RVMAVDALASSHPLSTPASEINTPAQISELFDAISYSKGASVLRMLSSFLSEDVFKQGLASYLHT 506

  Fly   474 NQYTSCDEWDLFASFQESADELGFTLPASVDDIFSSWSHQAGYPLLTVTRNYNAGTITITQKRYV 538
            ..|.:....:|:...||:.:.....||.:|.||.:.|:.|.|:|::||    :..|.|::|:.::
Human   507 FAYQNTIYLNLWDHLQEAVNNRSIQLPTTVRDIMNRWTLQMGFPVITV----DTSTGTLSQEHFL 567

  Fly   539 ANKTDTN-------SATWYVPLNFATANKYDYRD--TSATHYLLNVTETVISDV-EASSDDWIIV 593
            .: .|:|       :..|.||:.       ..||  ....::|::|...  :|: ..|.::|:::
Human   568 LD-PDSNVTRPSEFNYVWIVPIT-------SIRDGRQQQDYWLIDVRAQ--NDLFSTSGNEWVLL 622

  Fly   594 NIQNSGYYRTLYDTQNYGLITAALKSQPWRFHPRNRAQLLYDTYIFVSTDRLSHSILLELLGYLT 658
            |:..:||||..||.:|:..|...|:.........||||::.|.:...|..::..::.|....:|.
Human   623 NLNVTGYYRVNYDEENWRKIQTQLQRDHSAIPVINRAQIINDAFNLASAHKVPVTLALNNTLFLI 687

  Fly   659 NEQQYAPWSTANTILTVYDRYLRGDDSYYNFQDFVKRLIDPIFDKIGVN-----EIPGEHYLNNY 718
            .|:||.||..|.:.|:.:.......:.|...::::|:.:.|:|.....|     ||| |:.::.|
Human   688 EERQYMPWEAALSSLSYFKLMFDRSEVYGPMKNYLKKQVTPLFIHFRNNTNNWREIP-ENLMDQY 751

  Fly   719 LRIVLVSLACQVGSDDCYNQSANKLSEYLY--NGTAIEATLKTQAYCAGLRSTTNEIYSRVQSDL 781
            ..:..:|.||..|..:|....:....:::.  |...|...|::..||..:.....|.:.......
Human   752 SEVNAISTACSNGVPECEEMVSGLFKQWMENPNNNPIHPNLRSTVYCNAIAQGGEEEWDFAWEQF 816

  Fly   782 LSSSDSTDRSLFISSLGCSGSTSQLLDFLRLSLDTNNSLSYSERTSLLNS--------AYSRSEI 838
            .:::...:.....::|.||.....|          |..|||:....|:..        :.:.:.|
Human   817 RNATLVNEADKLRAALACSKELWIL----------NRYLSYTLNPDLIRKQDATSTIISITNNVI 871

  Fly   839 GLTASLEFLESNWE-----------AYANLSDSAKPLDAALRGIATYVVSEKQKTRLNALVDVVE 892
            |.....:|::|||:           :::||      :.|..|..:|    |.:..:|.......|
Human   872 GQGLVWDFVQSNWKKLFNDYGGGSFSFSNL------IQAVTRRFST----EYELQQLEQFKKDNE 926

  Fly   893 ADGPSYINDDLSTTIDSRITSNFAWLEVNRDPVLNWIEDSLK 934
            ..|.......|...:: :..:|..|::.|::.||.|..::.|
Human   927 ETGFGSGTRALEQALE-KTKANIKWVKENKEVVLQWFTENSK 967

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31343	NP_732652.1	Peptidase_M1	57..446	CDD:279741	148/412 (36%)
		M1_APN_2	65..517	CDD:189008	166/475 (35%)
		ERAP1_C	591..886	CDD:288671	68/320 (21%)
ANPEP	NP_001141.2	Cytosolic Ser/Thr-rich junction	33..68		6/34 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	40..62		3/21 (14%)
		Metalloprotease	69..967		270/942 (29%)
		M1_APN-Q_like	84..545	CDD:341064	164/469 (35%)
		Necessary and sufficient to mediate interaction with HCoV-229E. /evidence=ECO:0000269\|PubMed:1350662, ECO:0000269\|PubMed:8887485	288..295		0/6 (0%)
		Substrate binding. /evidence=ECO:0000269\|PubMed:22932899	352..356		3/3 (100%)
		ERAP1_C	619..946	CDD:403137	72/348 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165155438
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0308
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X67
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.850