DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31343 and Trhde

DIOPT Version :9

Sequence 1:	NP_732652.1	Gene:	CG31343 / 326133	FlyBaseID:	FBgn0051343	Length:	961	Species:	Drosophila melanogaster
Sequence 2:	NP_666353.2	Gene:	Trhde / 237553	MGIID:	2384311	Length:	1066	Species:	Mus musculus

Alignment Length:	1008	Identity:	273/1008 - (27%)
Similarity:	472/1008 - (46%)	Gaps:	113/1008 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 SLILLLAVCSLQARLILPLSLD-----------DGQL----ETKGAALFATSRVDDNSAG----- 54
            |::.||||..|  .::|.|..|           ||.|    |....:.|..|...::.||
Mouse    88 SIVALLAVTML--AVLLSLRFDECGASAAMPGTDGGLGGFPERDSNSSFPGSARRNHHAGGESSQ 150

  Fly    55 -----------------------------NYRLPNTTEPESYNVELWTNVHNGDTEFNGTVNIDI 90
                                         ..||....:|..||:.|...:.|  ..|:|.||::|
Mouse   151 RESGEVGTPGTPSAQPPSEEEREQWQPWTQLRLSGHLKPLHYNLMLTAFMEN--FTFSGEVNVEI 213

  Fly    91 RVLNETSNITLHYRQTSNFEATIISRDVATPTAIPLT---VTPELQREFLVLTQTTAGEAFGANT 152
            ...|.|..:.||..:.: .|...::.|.|. .|:|:.   :.|:.|...:||.:|     ..|..
Mouse   214 ACRNATRYVVLHASRVA-VEKVQVAEDRAF-GAVPVAGFFLYPQTQVLVVVLNRT-----LDAQR 271

  Fly   153 NWTITINYTGIHRSDMGGFYISSYTDDDGEQHFLATTQFESTNARHAFPCYDEPARRANFTITIH 217
            ::.:.|.|..:..:::.||:.|||. ..||:.||..|||..|:||.||||:|||..:|.|.|:|.
Mouse   272 HYNLKIIYNALIENELLGFFRSSYV-IHGERRFLGVTQFSPTHARKAFPCFDEPIYKATFKISIK 335

  Fly   218 HDPSYTAISNMPVNTAA--TSSGVT-AFQTTPKMSTYLVAFIVSDF---ESTTGELNGIRQRVFS 276
            |..:|.::|||||.|:.  ....|| .|..||.||||.:|:.:.:|   |:||  .:|:..|:::
Mouse   336 HQATYLSLSNMPVETSVFEEDGWVTDHFSQTPLMSTYYLAWAICNFTYRETTT--KSGVVVRLYA 398

  Fly   277 RKG--KQDQQEWALWSGLLVESSLASYFGVPFALPKLDQAGIPDFSAGAMENWGLATYREQYMWW 339
            |..  ::...::||.....:......||.||::|||||...:|.....|||||||:.:.||.:..
Mouse   399 RPDAIRRGSGDYALHITKRLIEFYEDYFKVPYSLPKLDLLAVPKHPYAAMENWGLSIFVEQRILL 463

  Fly   340 NKQNSTINLKTNIANIIGHEYAHMWFGDLVSIKWWTYLWLKEGFATLFSYESNDIAFPLWD-TYQ 403
            :...|:|:...::..:|.||..|.||||||:..||..:|||||||..|.:...|..:|.|: ..|
Mouse   464 DPSVSSISYLLDVTMVIVHEICHQWFGDLVTPVWWEDVWLKEGFAHYFEFVGTDYLYPAWNMEKQ 528

  Fly   404 IFHVNDYNSALLNDALASAVPMTHYVQTPSEISNRYNTFSYAKPASVLYMFKNAWTDKVFRTGLN 468
            .|..:..:..:|.|.|||:.|::..|...::|...::..:|.|.|:::.|..|.....||:.||.
Mouse   529 RFLTDVLHEVMLLDGLASSHPVSQEVLRATDIDRVFDWIAYKKGAALIRMLANFMGHSVFQRGLQ 593

  Fly   469 KYLTKNQYTSCDEWDLFASFQESADELGFTLPASVDDIFSSWSHQAGYPLLTVTRNYNA-GTITI 532
            .|||.::|.:....||:.:..|:....|..:  ::.::...|:.|.|||::|:..|..| ..|.|
Mouse   594 DYLTIHKYGNAARNDLWNTLSEALRRNGKYV--NIQEVMDQWTLQMGYPVITILGNTTAENRILI 656

  Fly   533 TQKRYV--------ANKTDTNSATWYVPLNFATANKYDYRDTSATHYLLNVTE-TVISDVEASSD 588
            ||:.::        |.:...:|..|.:||.....|: .:..:.|..::.|.:| ..|:.::..|
Mouse   657 TQQHFIYDIGAKTKALQLQNSSYLWQIPLTIVVGNR-SHVSSEAIIWVSNKSEHHRIAYLDRGS- 719

  Fly   589 DWIIVNIQNSGYYRTLYDTQNYGLITAALKSQPWRFHPRNRAQLLYDTYIFVSTDRLSHSILLEL 653
             ||:.||..:||:|..||.:|:.|:...|..........|||.|:.|.:.......|..:|.||:
Mouse   720 -WILGNINQTGYFRVNYDLRNWRLLIDQLIRNHEVLSVSNRAALIDDAFSLARAGYLPQNIPLEI 783

  Fly   654 LGYLTNEQQYAPWSTANTILTVYDRYLRGDDSYYNFQDFVKRLIDPIFDKIG--VNEIPGE---- 712
            :.||:.|:.:.||..|:..|...|:.|...::|..|.:::.:.:...:.|:|  .|...|.
Mouse   784 IRYLSEEKDFLPWHAASRALYPLDKLLDRMENYNIFNEYILKQVATTYIKLGWPRNNFNGSLVQA 848

  Fly   713 HYLNNYLRIVLVSLACQVGSDDCYNQSANKLSEYL-YNGTAIEATLKTQAYCAGLRSTTNEIYSR 776
            .|.:..||..::.|||..|:..|:.|::..:|::: .|...|...::...||.|:.....:::..
Mouse   849 SYQHEELRREVIMLACSFGNKHCHQQASTLISDWISSNRNRIPLNVRDIVYCTGVSLLDEDVWEF 913

  Fly   777 VQSDLLSSSDSTDRSLFISSLGCSGSTSQLLDFLRLSLDTNNSLSYSERTSLLNSAYSRSEIGLT 841
            :.....|::..:::.:.:.:|.||...:.|...|.|||::...|.......:::.|  |:..|..
Mouse   914 IWMKFHSTTAVSEKKILLEALTCSDDRNLLSRLLNLSLNSEVVLDQDAIDVIIHVA--RNPHGRD 976

  Fly   842 ASLEFLESNWEAYANLSDSAKPLDAAL-RGIATYVVSEKQKTRLNALVDVVEADGPSYINDDLST 905
            .:.:|....|:........|..:::.| .|:..::.:|.:...|...:       .||  |.:::
Mouse   977 LAWKFFRDKWKILNTRYGEALFMNSKLISGVTEFLNTEGELKELKNFM-------KSY--DGVAS 1032

  Fly   906 TIDSR----ITSNFAWLEVNRDPVLNWIEDSLK 934
            ...||    :.:|..|....:|.:..|:..:::
Mouse  1033 ASFSRAVETVEANVRWKRFYQDELFQWLGKAMR 1065

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31343	NP_732652.1	Peptidase_M1	57..446	CDD:279741	137/400 (34%)
		M1_APN_2	65..517	CDD:189008	153/463 (33%)
		ERAP1_C	591..886	CDD:288671	70/302 (23%)
Trhde	NP_666353.2	M1_APN-Q_like	190..635	CDD:341064	151/458 (33%)
Trhde	NP_666353.2	ERAP1_C	720..1044	CDD:378732	76/334 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167845835
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X67
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.950