DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31343 and LVRN

DIOPT Version :9

Sequence 1:	NP_732652.1	Gene:	CG31343 / 326133	FlyBaseID:	FBgn0051343	Length:	961	Species:	Drosophila melanogaster
Sequence 2:	NP_776161.3	Gene:	LVRN / 206338	HGNCID:	26904	Length:	990	Species:	Homo sapiens

Alignment Length:	937	Identity:	261/937 - (27%)
Similarity:	443/937 - (47%)	Gaps:	116/937 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    57 RLPNTTEPESYNVELWTNVH-----NGDTEFNGTVNIDIRVLNETSNITLH--YRQTSNFEATII 114
            |||....|..|::|||..:.     .|...|.|.|||.:|....||.:.||  ::.....|.
Human    97 RLPPWLVPLHYDLELWPQLRPDELPAGSLPFTGRVNITVRCTVATSRLLLHSLFQDCERAEV--- 158

  Fly   115 SRDVATPTAIPLTV--TP------ELQREFLVLTQTTAGEAFGANTNWTITINYTGIHRSDM-GG 170
             |...:|.....||  .|      .|..|::||   ...|.....:::.:.::::|:.:.|: .|
Human   159 -RGPLSPGTGNATVGRVPVDDVWFALDTEYMVL---ELSEPLKPGSSYELQLSFSGLVKEDLREG 219

  Fly   171 FYISSYTDDDGEQHFLATTQFESTNARHAFPCYDEPARRANFTITIHHDPSYTAISNMP------ 229
            .:::.|| |.||:..|..:|.|.|.||:.|||:||||.:|.|.||:.|.|||.|:||||
Human   220 LFLNVYT-DQGERRALLASQLEPTFARYVFPCFDEPALKATFNITMIHHPSYVALSNMPKLGQSE 283

  Fly   230 ---VNTAATSSGVTAFQTTPKMSTYLVAFIVSDFESTTGELNGIRQRVFSRK-----GKQDQQEW 286
               ||.:..:  ||.|.|||.|.||||||::.|::.......|...|:::||     |..|   :
Human   284 KEDVNGSKWT--VTTFSTTPHMPTYLVAFVICDYDHVNRTERGKEIRIWARKDAIANGSAD---F 343

  Fly   287 ALWSGLLVESSLASYFGVPFALPKLDQAGIPDFSAGAMENWGLATYREQYMWWNKQNSTINLKTN 351
            ||.....:.|.|...|.:.::|||.|...:|.|...|||||||..:.|..:....::.....||.
Human   344 ALNITGPIFSFLEDLFNISYSLPKTDIIALPSFDNHAMENWGLMIFDESGLLLEPKDQLTEKKTL 408

  Fly   352 IANIIGHEYAHMWFGDLVSIKWWTYLWLKEGFATLFSYESNDIAFPLWDTYQIFHVNDYNSALLN 416
            |:.::.||..|.|||:||::.||..:||.||||:.|.:|..:...|.....:||..|..::.|..
Human   409 ISYVVSHEIGHQWFGNLVTMNWWNNIWLNEGFASYFEFEVINYFNPKLPRNEIFFSNILHNILRE 473

  Fly   417 D-ALAS-AVPMTHYVQTPSEISNRYNTFSYAKPASVLYMFKNAWTDKVFRTGLNKYLTKNQYTSC 479
            | ||.: ||.|.......|||...::.|:|:|.||:..|......:.:|.:.|..||....|::.
Human   474 DHALVTRAVAMKVENFKTSEIQELFDIFTYSKGASMARMLSCFLNEHLFVSALKSYLKTFSYSNA 538

  Fly   480 DEWDLFASFQESADELG-FTLPASVDDIFSSWSHQAGYPLLTVTRNYNAGTITITQKRY----VA 539
            ::.||:..||.:.|:.. ..|||::.:|..||:||:|:|::|:    |..|..:.|:.:    :.
Human   539 EQDDLWRHFQMAIDDQSTVILPATIKNIMDSWTHQSGFPVITL----NVSTGVMKQEPFYLENIK 599

  Fly   540 NKT-DTNSATWYVPLNF---ATANKYDYRDTSATHYLLNVTETVISDVEASSDDWIIVNIQNSGY 600
            |:| .|::.||.||:.:   .|.....:.|.|:..:    .|..:||   |..||:|:|:..:||
Human   600 NRTLLTSNDTWIVPILWIKNGTTQPLVWLDQSSKVF----PEMQVSD---SDHDWVILNLNMTGY 657

  Fly   601 YRTLYDTQNYGLITAALKSQPWRFHPRNRAQLLYDTYIFVSTDRLSHSILLELLGYLTNEQQYAP 665
            ||..||...:..:...|:..|......:|.||:.|.:.....:.:.....|||..||..|.:...
Human   658 YRVNYDKLGWKKLNQQLEKDPKAIPVIHRLQLIDDAFSLSKNNYIEIETALELTKYLAEEDEIIV 722

  Fly   666 WSTANTILTVYDRYLRGDDSYYNFQDFVKR-------LIDPIFDKIGVNEIPGEHYL---NNYLR 720
            |.|  .::.:..|.|..:.:.|:....:||       ||..|:     :.|..|:.|   ::||.
Human   723 WHT--VLVNLVTRDLVSEVNIYDIYSLLKRYLLKRLNLIWNIY-----STIIRENVLALQDDYLA 780

  Fly   721 IV----LVSLACQVGSDDCYNQSANKLSEYL-YNGTAIEATLKTQAYCAGLRSTTNEIYSRVQSD 780
            ::    |...||.:|.:||...|....:::: :....|...:|....|.|:...:::.:..:.:.
Human   781 LISLEKLFVTACWLGLEDCLQLSKELFAKWVDHPENEIPYPIKDVVLCYGIALGSDKEWDILLNT 845

  Fly   781 LLSSSDSTDRSLFISSLGCSGSTSQLLDFLRLSLDTNNSLSYSERTSLLNSAYSRSEIGLTASLE 845
            ..::::..::.....::.||.....|..::..::.|  |...|..|:::....| ||:|...:.:
Human   846 YTNTTNKEEKIQLAYAMSCSKDPWILNRYMEYAIST--SPFTSNETNIIEVVAS-SEVGRYVAKD 907

  Fly   846 FLESNWEAYANLSDSAKPLD---------------AALRGIATYVVSEKQKTRLNALVDVVEADG 895
            ||.:||:|.:....:...::               ..|:...:.::.|.|:.|::|.:..::
Human   908 FLVNNWQAVSKRYGTQSLINLIYTIGRTVTTDLQIVELQQFFSNMLEEHQRIRVHANLQTIK--- 969

  Fly   896 PSYINDDL-STTIDSRITSNFAWLEVN 921
                |::| :..:.:||.   |||..|
Human   970 ----NENLKNKKLSARIA---AWLRRN 989

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31343	NP_732652.1	Peptidase_M1	57..446	CDD:279741	142/420 (34%)
		M1_APN_2	65..517	CDD:189008	161/484 (33%)
		ERAP1_C	591..886	CDD:288671	66/324 (20%)
LVRN	NP_776161.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	48..91
		Peptidase_M1	97..506	CDD:279741	142/421 (34%)
		M1_APN_2	105..577	CDD:189008	161/484 (33%)
		Substrate binding. /evidence=ECO:0000250	379..383		2/3 (67%)
		ERAP1_C	648..951	CDD:288671	63/312 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165155416
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0308
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.850