DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31343 and ENPEP

DIOPT Version :9

Sequence 1:	NP_732652.1	Gene:	CG31343 / 326133	FlyBaseID:	FBgn0051343	Length:	961	Species:	Drosophila melanogaster
Sequence 2:	NP_001968.3	Gene:	ENPEP / 2028	HGNCID:	3355	Length:	957	Species:	Homo sapiens

Alignment Length:	961	Identity:	258/961 - (26%)
Similarity:	440/961 - (45%)	Gaps:	171/961 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    55 NYRLPNTTEPESYNVELWTNVHNGDTEFNGTVNIDIRVLNETSNITLHYRQTSNFEATIISRDVA 119
            |:|||:...|..|::.:...:.. || :.|||:|.|.:...|..:.||.|:|.
Human    90 NFRLPDFVNPVHYDLHVKPLLEE-DT-YTGTVSISINLSAPTRYLWLHLRETR------------ 140

  Fly   120 TPTAIPLTVTPELQR-----------------EFLVL---TQTTAGEAFGANTNWTITINYTGIH 164
                  :|..|||:|                 |::|:   .:.|.....|.   :.:|:.:.|..
Human   141 ------ITRLPELKRPSGDQVQVRRCFEYKKQEYVVVEAEEELTPSSGDGL---YLLTMEFAGWL 196

  Fly   165 RSDMGGFYISSYTDDDGEQHFLATTQFESTNARHAFPCYDEPARRANFTITIHHDPSYTAISNMP 229
            ...:.|||.::|| ::|:...:..|..|.|:||.:|||:|||.::|.:||:|.|...|.|:||||
Human   197 NGSLVGFYRTTYT-ENGQVKSIVATDHEPTDARKSFPCFDEPNKKATYTISITHPKEYGALSNMP 260

  Fly   230 VNTAATSSGV------TAFQTTPKMSTYLVAFIVSDFESTTGELNGIRQRVFSRKGK-------Q 281
            |   |....|      |.|:.:..||||||.|.|..|:|.        :|: |..||       .
Human   261 V---AKEESVDDKWTRTTFEKSVPMSTYLVCFAVHQFDSV--------KRI-SNSGKPLTIYVQP 313

  Fly   282 DQQEWALWSGLLVES---SLASYFGVPFALPKLDQAGIPDFSAGAMENWGLATYREQYMWWNKQN 343
            :|:..|.::..:.:|   ....||.:.::|||||:..||||..||||||||.||||..:.::.:.
Human   314 EQKHTAEYAANITKSVFDYFEEYFAMNYSLPKLDKIAIPDFGTGAMENWGLITYRETNLLYDPKE 378

  Fly   344 STINLKTNIANIIGHEYAHMWFGDLVSIKWWTYLWLKEGFATLFSYESNDIAFPLWDTYQIFHVN 408
            |..:.:..:|.::.||..|.|||::|::.||..|||.||||:.|.:...:.|...|.......:.
Human   379 SASSNQQRVATVVAHELVHQWFGNIVTMDWWEDLWLNEGFASFFEFLGVNHAETDWQMRDQMLLE 443

  Fly   409 DYNSALLNDALASAVPMTHYVQTPSEISNRYNTFSYAKPASVLYMFKNAWTDKVFRTGLNKYLTK 473
            |......:|:|.|:.|:...|.||.||::.::..||:|.:|:|.|.::....:.|:.|...||.|
Human   444 DVLPVQEDDSLMSSHPIIVTVTTPDEITSVFDGISYSKGSSILRMLEDWIKPENFQKGCQMYLEK 508

  Fly   474 NQYTSCDEWDLFASFQESADELGFTLPASVDDIFSSWSHQAGYPLLTVTRNYNAGTITITQKRYV 538
            .|:.:....|.:|:.:|::     .||  |.::..:|:.|.|||:|.|.     |...|||||::
Human   509 YQFKNAKTSDFWAALEEAS-----RLP--VKEVMDTWTRQMGYPVLNVN-----GVKNITQKRFL 561

  Fly   539 ----ANKTDTNS---ATWYVPLNFATANKYDYRDTSATHYLLNVTE---TVISDVEASSDDWIIV 593
                ||.:...|   .||.:|:.:.       .|...:..|.|.:|   ..::....|.:.::.:
Human   562 LDPRANPSQPPSDLGYTWNIPVKWT-------EDNITSSVLFNRSEKEGITLNSSNPSGNAFLKI 619

  Fly   594 NIQNSGYYRTLYDTQNYGLITAALKSQPWRFHPRNRAQLLYDTYIFVSTDRLSHSILLELLGYLT 658
            |..:.|:||..|:...:..|..||......|...:||.|:.|.:.......|.:.:.|.|..||.
Human   620 NPDHIGFYRVNYEVATWDSIATALSLNHKTFSSADRASLIDDAFALARAQLLDYKVALNLTKYLK 684

  Fly   659 NEQQYAPW----STANTILTVYDRYLRGDDS--YYNFQDFVKRLIDPIFDKIGVNEIPGEHYLNN 717
            .|:.:.||    |....|:::::     ||.  |...:::.:..:.||.|.:|.|: .|:| :..
Human   685 REENFLPWQRVISAVTYIISMFE-----DDKELYPMIEEYFQGQVKPIADSLGWND-AGDH-VTK 742

  Fly   718 YLRIVLVSLACQVGSDDCYNQSANKLSEYLYNGT-AIEATLKTQAYCAGLRSTTNEI---YSRVQ 778
            .||..::..||::|..:..| :|:.|.|...||| ::...|:...|..|::::.|||   |:..|
Human   743 LLRSSVLGFACKMGDREALN-NASSLFEQWLNGTVSLPVNLRLLVYRYGMQNSGNEISWNYTLEQ 806

  Fly   779 SDLLSSSDSTDRSLF-ISSLGCSGSTSQLLDFLRLSLDTNNSLSYSERTSLLNSAYSRSEIGLTA 842
            ....|.:...::.|: ::|:......|:.||.|:   |||...:....|.:...:|  :..|...
Human   807 YQKTSLAQEKEKLLYGLASVKNVTLLSRYLDLLK---DTNLIKTQDVFTVIRYISY--NSYGKNM 866

  Fly   843 SLEFLESNWEAYANLSDSAKPLDAALRGIATYVVSEKQKTRLNALVDVVEADGPSYINDDLS--- 904
            :..:::.||:...|                .|.::.:   .|..:|.:.|.     .|.:|.
Human   867 AWNWIQLNWDYLVN----------------RYTLNNR---NLGRIVTIAEP-----FNTELQLWQ 907

  Fly   905 ------------------TTIDSRITSNFAWLEVNRDPVLNWIEDSLKENG 937
                              ..:...:.:|..||:.:|:.:..|. .:|.|:|
Human   908 MESFFAKYPQAGAGEKPREQVLETVKNNIEWLKQHRNTIREWF-FNLLESG 957

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31343	NP_732652.1	Peptidase_M1	57..446	CDD:279741	134/424 (32%)
		M1_APN_2	65..517	CDD:189008	149/487 (31%)
		ERAP1_C	591..886	CDD:288671	71/305 (23%)
ENPEP	NP_001968.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	44..83
		Peptidase_M1	92..482	CDD:279741	134/425 (32%)
		M1_APN_2	100..545	CDD:189008	149/487 (31%)
		Substrate binding. /evidence=ECO:0000269\|PubMed:23888046, ECO:0007744\|PDB:4KXA, ECO:0007744\|PDB:4KXB, ECO:0007744\|PDB:4KXC, ECO:0007744\|PDB:4KXD	357..361		3/3 (100%)
		ERAP1_C	617..931	CDD:288671	75/350 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0308
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X67
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.920