DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31343 and Npepps

DIOPT Version :9

Sequence 1:	NP_732652.1	Gene:	CG31343 / 326133	FlyBaseID:	FBgn0051343	Length:	961	Species:	Drosophila melanogaster
Sequence 2:	NP_032968.2	Gene:	Npepps / 19155	MGIID:	1101358	Length:	920	Species:	Mus musculus

Alignment Length:	987	Identity:	273/987 - (27%)
Similarity:	445/987 - (45%)	Gaps:	132/987 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 LLLAVCSLQARLIL------PL-------SLDDGQLETKGAALFATSRVDDNSAGNYRLPNTTEP 64
            |..||.||..||:|      ||       |....:|.:.|.|.....|..:      |||....|
Mouse     3 LAAAVPSLARRLLLLGPPPPPLLLLLSRSSRRRRRLHSLGLAAMPEKRPFE------RLPAEVSP 61

  Fly    65 ESYNVELWTNVHNGDTEFNGTVNIDIRVLNETSNITLHYRQTSNFEATIISRDVATPTAIPLTVT 129
            .:|::.|..::.  |..|.|.:....:|...|:.|.::            ..|:...||   :..
Mouse    62 INYSLCLKPDLL--DFTFEGKLEAAAQVRQATNQIVMN------------CADIDIITA---SYA 109

  Fly   130 PELQRE------------------FLVLTQTTAGEAFGANTNWTITINYTGIHRSDMGGFYISSY 176
            ||...|                  |....||..|         |:.|::.|.....|.|||.|.|
Mouse   110 PEGDEEIHATGFNYQNEDEKVTLSFPSTLQTGTG---------TLKIDFVGELNDKMKGFYRSRY 165

  Fly   177 TDDDGEQHFLATTQFESTNARHAFPCYDEPARRANFTITIHHDPSYTAISNMPV----------N 231
            |...||..:.|.||||:|:||.||||:||||.:|.|.|::.......|:|||.|          |
Mouse   166 TTPAGEVRYAAVTQFEATDARRAFPCWDEPAIKATFDISLVVPKDRVALSNMNVIDRKPYPDDEN 230

  Fly   232 TAATSSGVTAFQTTPKMSTYLVAFIVSDFEST-TGELNGIRQRVFSRKGKQDQQEWALWSGLLVE 295
            .....     |..||.||||||||:|.:::.. |...:|:..||::..||.:|.::||.......
Mouse   231 LVEVK-----FARTPVMSTYLVAFVVGEYDFVETRSKDGVCVRVYTPVGKAEQGKFALEVAAKTL 290

  Fly   296 SSLASYFGVPFALPKLDQAGIPDFSAGAMENWGLATYREQYMWWNKQNSTINLKTNIANIIGHEY 360
            .....||.||:.|||:|...|.||:|||||||||.||||..:..:.:||..:.:..:|.::|||.
Mouse   291 PFYKDYFNVPYPLPKIDLIAIADFAAGAMENWGLVTYRETALLIDPKNSCSSSRQWVALVVGHEL 355

  Fly   361 AHMWFGDLVSIKWWTYLWLKEGFATLFSYESNDIAFPLWDTYQIFHVNDYNSALLNDALASAVPM 425
            ||.|||:||:::|||:|||.||||:...|...|..||.:|.:..|...||..|...|||.::.|:
Mouse   356 AHQWFGNLVTMEWWTHLWLNEGFASWIEYLCVDHCFPEYDIWTQFVSADYTRAQELDALDNSHPI 420

  Fly   426 THYVQTPSEISNRYNTFSYAKPASVLYMFKNAWTDKVFRTGLNKYLTKNQYTSCDEWDLFASFQE 490
            ...|..|||:...::..||:|.|||:.|..:...||.|:.|:|.||||.|..:....||:.|.:.
Mouse   421 EVSVGHPSEVDEIFDAISYSKGASVIRMLHDYIGDKDFKKGMNMYLTKFQQKNAATEDLWESLES 485

  Fly   491 SADELGFTLPASVDDIFSSWSHQAGYPLLTVTRNY--NAGTITITQKRYVANKT--DTNSATWYV 551
            ::.:       .:..:.::|:.|.|:||:.|....  :...:.::||::.|:..  ..:...|.|
Mouse   486 ASGK-------PIAAVMNTWTKQMGFPLIYVEAEQVEDDRVLKLSQKKFCASGPYGGEDCPQWMV 543

  Fly   552 PLNFATANKYDYRDTSATHYLLNVTETVISDVEASSDDWIIVNIQNSGYYRTLYDTQNYGLITAA 616
            |:..:|:   :..:.:....|::..|..:.......|.|:.:|:...|:|||.|.:.....:...
Mouse   544 PITISTS---EDPNQAKLKILMDKPEMSVVLKNVKPDQWVKLNLGTVGFYRTQYSSAMLESLLPG 605

  Fly   617 LK--SQPWRFHPRNRAQLLYDTYIFVSTDRLSHSILLELLGYLTNEQQYAPWSTANTILTVYDRY 679
            ::  |.|    |.:|..|..|.:.......:|...:|:::....||..|..||..:..|.:....
Mouse   606 IRDLSLP----PVDRLGLQNDLFSLARAGIISTVEVLKVMEAFVNEPNYTVWSDLSCNLGILSTL 666

  Fly   680 LRGDDSYYNFQDFVKRLIDPIFDKIGVNEIPGEHYLNNYLRIVLVSLACQVGSDDCYNQSANKLS 744
            |...|.|...|:|||.:..||.:::|.:..|||.:|:..||.:::....:.|......::..:..
Mouse   667 LSHTDFYEEIQEFVKDVFSPIGERLGWDPKPGEGHLDALLRGLVLGKLGKAGHKATLEEARRRFK 731

  Fly   745 EYLYNGTAIEATLKTQAYCAGLR---STTNEIYSRV--QSDLLSSSDSTDRSLFISSLGCSGSTS 804
            |::.....:.|.|::..|...|:   ..|.:|..::  |:|:....:..:|     .||.:.|..
Mouse   732 EHVEGKQILSADLRSPVYLTVLKHGDGATLDIMLKLHKQADMQEEKNRIER-----VLGATLSPE 791

  Fly   805 QLLDFLRLSLDTNNSLSYSERTSLLNSAYSRSEIGLTASLEFLESNWEAYANLSDS----AKPLD 865
            .:...|..:|  :..:...:..|::......|:.|..|:.:|::.|||...|....    ::.:.
Mouse   792 LIQKVLTFAL--SEEVRPQDTVSVIGGVAGGSKHGRKAAWKFIKDNWEELHNRYQGGFLISRLIK 854

  Fly   866 AALRGIATYVVSEKQKTRLNALVDVVEADGPSYINDDLSTTID---SRITSNFAWLEVNRDPVLN 927
            .::.|.|           ::.:...|:|...|:.......||.   ..|..|.|||:.:.|.:..
Mouse   855 LSVEGFA-----------VDKMAGEVKAFFESHPAPSAERTIQQCCENILLNAAWLKRDADSIHQ 908

  Fly   928 WIEDSLKENGSP 939
            ::   |:...||
Mouse   909 YL---LQRKTSP 917

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31343	NP_732652.1	Peptidase_M1	57..446	CDD:279741	146/417 (35%)
		M1_APN_2	65..517	CDD:189008	163/480 (34%)
		ERAP1_C	591..886	CDD:288671	63/305 (21%)
Npepps	NP_032968.2	Peptidase_M1	54..442	CDD:279741	146/418 (35%)
		M1_APN_2	62..505	CDD:189008	163/480 (34%)
		Substrate binding. /evidence=ECO:0000250	317..321		3/3 (100%)
		ERAP1_C	580..891	CDD:288671	68/332 (20%)
		Nuclear localization signal. /evidence=ECO:0000255	727..731		0/3 (0%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0308
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S1087
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X67
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.770