DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31343 and R03G8.6

DIOPT Version :9

Sequence 1:	NP_732652.1	Gene:	CG31343 / 326133	FlyBaseID:	FBgn0051343	Length:	961	Species:	Drosophila melanogaster
Sequence 2:	NP_510175.1	Gene:	R03G8.6 / 181438	WormBaseID:	WBGene00011000	Length:	747	Species:	Caenorhabditis elegans

Alignment Length:	762	Identity:	200/762 - (26%)
Similarity:	331/762 - (43%)	Gaps:	100/762 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    46 SRVDDNSAGNYRLPNTTEPESYNVEL--------WTNVHNGDTEFNGTVNIDIRVLNETSNITLH 102
            :|:.|  ..:||||....|..|::.:        |....|..| |.|.|||.:.:...|..:.||
Worm    22 ARIAD--VASYRLPRHVSPSHYDIHIKTYLPGYGWKADENKIT-FEGNVNILLDIKETTDKLVLH 83

  Fly   103 YRQTSNFEATIISRDVATPTAIPLTVTPELQREFL-------VLTQTTAGEAFGANTNWTITINY 160
            ....:...||..| |....:.....|..|.|  ||       |..|::||          |.||:
Worm    84 SSSLNIISATFQS-DEQNVSISHWNVQTESQ--FLTFYLNNTVKVQSSAG----------IQINF 135

  Fly   161 TGIHRSDMGGFYISSYTDDDGEQHFLATTQFESTNARHAFPCYDEPARRANFTITIHHDPSYTAI 225
            .|..|:|..|.:.::.|.:||.......||||:..||:..||:|||..:|.:.:::.|....||:
Worm   136 QGKVRTDGLGLFATNSTREDGTVMTNFATQFETIFARNMIPCFDEPEFKATWNVSLEHPTGSTAL 200

  Fly   226 SN-MPVNTAATSS-GVTAFQTTPKMSTYLVAFIVSDFESTTGEL-NGIRQRVFSRKGKQDQQEWA 287
            || :.|.:..... ..|.::.|.|||:|::|..:.|.:.....| ||:|.||::.....|:.:.|
Worm   201 SNGIEVESKVNDDWKTTTYKKTLKMSSYILALFIGDIQFKETILNNGVRIRVYTDPVNIDRVDHA 265

  Fly   288 LWSGLLVESSLASYFGVPFALPKLDQAGIPDFSAGAMENWGLATYREQYMWWNKQNSTINLKTNI 352
            |....:|.......||:.:.:.|||...:.:|..||||||||..:...        |.|....::
Worm   266 LNISRIVLEGFERQFGIRYPMEKLDFVSVQNFKFGAMENWGLVIHNAY--------SLIGDPMDV 322

  Fly   353 ANIIGHEYAHMWFGDLVSIKWWTYLWLKEGFATLFSYESNDIAFPLWDTYQ--IFHVNDYNSALL 415
            ..|:.||.||.|||:||::|:|.::||.||||:..:  |..:.| |...||  .|::|...:..:
Worm   323 TEIVIHEIAHQWFGNLVTMKYWDHIWLNEGFASYMT--SYGLTF-LDPDYQRDTFYLNCQFNPQI 384

  Fly   416 NDALASAVPMTHYVQTPSEISNRYNTFSYAKPASVLYMFKNAWTDKVFRTGLNKYLTKNQYTSCD 480
            ||...|    .::.:..|.:.|...|. |.|..|.:.|.:|.:..:.|...:..||.||||.:.|
Worm   385 NDGGVS----LNFGKNLSSVMNNAATV-YMKGCSFVRMLENIFGTEYFNEAIKFYLEKNQYDNVD 444

  Fly   481 EWDLFASFQESADELGFT-LPASVDDIFSSWSHQAGYPLLTVTRNYNAGTIT---ITQKRYVANK 541
            :.||:.:|:.|::.|... .|..::.....|:||.|:|.:.|:.:....|:|   :.:.:.:.|:
Worm   445 DNDLYEAFRTSSETLDTNGKPFDIEKFARCWTHQNGFPTIQVSNDNGIATLTQSHLYEPQLMLNE 509

  Fly   542 TDTNSATWYVPLNFATANKYDYRDTSATHYLLNVTETVISDVEASSDDWIIVNIQNSGYYRTLYD 606
            .|..   |.:|:.:....     :.......||...|   .:|..:||.:|:|..:.|||..||.
Worm   510 CDYK---WDIPIWYQEPG-----EARVQMAWLNRNST---SLELVADDSVIINANSIGYYEVLYS 563

  Fly   607 TQNYGLITAALKSQPWRFHPRNRAQLLYDTY--------------------IFVSTDRLSHSILL 651
            .:.|..|...:.....|:...:..:.|:|.:                    :|...:.|.|..:|
Worm   564 DKMYEKIAEQVAINVSRYSVNSLRRTLHDVFRYSRDGLTPFHNAFIIAYVLVFGENEILRHESVL 628

  Fly   652 ELLG--YLTNEQQYAPWSTANTILTVYDRYLRGDDSYYNFQDFVKRLIDPIFDKIGVNEIPGEHY 714
            .|:.  |.||.:.........|:..:.::       ..||:.|.|.:....|.......||....
Worm   629 YLVDAVYNTNNKSIVNSKDIETVKGLVNQ-------IENFELFPKCVQSQTFSSCYQKRIPQNIN 686

  Fly   715 LNNYLRIVLVSLACQV---GSDDCYNQSANKLSEYLYNGTAIEATLK 758
            |...:::.|......:   .:::..|:.| ||...|..|.:.:..||
Worm   687 LRAIMQLKLSQNTMDLIVAWAENGVNEEA-KLGPKLMLGCSTKENLK 732

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31343	NP_732652.1	Peptidase_M1	57..446	CDD:279741	123/408 (30%)
		M1_APN_2	65..517	CDD:189008	141/472 (30%)
		ERAP1_C	591..886	CDD:288671	38/193 (20%)
R03G8.6	NP_510175.1	Peptidase_M1	31..389	CDD:279741	118/382 (31%)
		M1_APN_2	39..482	CDD:189008	141/472 (30%)
		ERAP1_C	548..>622	CDD:288671	13/73 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0308
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.920