DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31343 and anp-1

DIOPT Version :9

Sequence 1:	NP_732652.1	Gene:	CG31343 / 326133	FlyBaseID:	FBgn0051343	Length:	961	Species:	Drosophila melanogaster
Sequence 2:	NP_001041160.1	Gene:	anp-1 / 179763	WormBaseID:	WBGene00011587	Length:	988	Species:	Caenorhabditis elegans

Alignment Length:	1043	Identity:	271/1043 - (25%)
Similarity:	446/1043 - (42%)	Gaps:	208/1043 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 LLLAVCSLQARLILPL----------SLDDGQLETKGAALFATSRVDDNSAGNYRLPNTTEPESY 67
            :|...|:|...||...          |.:|...|.:...:.|....|:.||...|||.:..|.||
Worm    31 VLPVFCTLLGVLITAFITWHITKSQYSRNDPHDEIESENVPAAKPEDNISASELRLPTSVSPISY 95

  Fly    68 NVELWT-------NVHNGDTEFNGTVNIDIRVLNETSNITLHYRQTSNFEATIISRD--VATPTA 123
            .:.:.|       .....:..|.|.|.|::.:......::|:.:.. |:....|.:.  :....:
Worm    96 QLTVKTYLPGYGYTADKNNLTFEGQVLIELNITKSIKKVSLNSKDL-NYTEEFIKKSSILVNGKS 159

  Fly   124 IPLTVTPEL---QREFLVLTQTTAGEAFGANTNWTITINYTGIHRSDMGGFYISSYTDDDGEQHF 185
            |..|:..:.   ::.|..|.:|..     ..|:.|:.:.:....|:||.|.|.::||:..||...
Worm   160 IAFTLDDKQSTHEKIFFNLDETVE-----PTTSATLKVAFGAPLRTDMSGLYQTTYTNSKGESKM 219

  Fly   186 LATTQFESTNARHAFPCYDEPARRANFTITIHHDPSYTAISNMPVNTAATSSG------------ 238
            .|.||.|...||...||:||||.:|.:|:|:.|          |..|.|.|:|
Worm   220 AAVTQMEPVYARRMVPCFDEPAYKATWTVTVIH----------PNKTVAVSNGIEDKVEDGQPGF 274

  Fly   239 -VTAFQTTPKMSTYLVAFIVSDF---ESTTGELNGIRQRVFSRKGKQDQQEWALWSGLLVESSLA 299
             ::.|:.||:||:||:|..:|:|   |:||  .:|:|.||:||..:::...:|:.:|:.......
Worm   275 IISTFKPTPRMSSYLLAIFISEFEYNEATT--KSGVRFRVWSRPEEKNSTMYAVEAGVKCLEYYE 337

  Fly   300 SYFGVPFALPKLDQAGIPDFSAGAMENWGLATYREQYMWWNKQNSTINLKTNIANIIGHEYAHMW 364
            .|:.:.|.|||.|...:|||||||||||||.||||..:.::.:..:.:.|..:|.:|.||.||.|
Worm   338 KYYNISFPLPKQDMVALPDFSAGAMENWGLITYRESALLYDPRIYSGSQKRRVAVVIAHELAHQW 402

  Fly   365 FGDLVSIKWWTYLWLKEGFATLFSYESNDIAFPLWDTYQIFHVNDYN-------------SALLN 416
            ||:||::|||..|||.||||||..|...|            .::|.|             |||..
Worm   403 FGNLVTLKWWNDLWLNEGFATLVEYLGTD------------EISDGNMRMREWFTMDALWSALAA 455

  Fly   417 DALASAVPMTHYVQTPSEISNRYNTFSYAKPASVLYMFKNAWTDKVFRTGLNKYLTKNQYTSCDE 481
            |::||..|:|..:....|:.:.:::.:|.|..:||.|.:....::.|.||:|.|||::|:.:.|.
Worm   456 DSVASTHPLTFKIDKAMEVLDSFDSVTYDKGGAVLAMVRKTIGEENFNTGINHYLTRHQFDNADA 520

  Fly   482 WDLFASFQESADELGFTLPASV----------DDIFSSWSHQAGYPLLTVTRNYNAGTITITQKR 536
            .:|..:       ||..:|.||          .:....|:.|.|||||..:| .|...|.:.|.|
Worm   521 GNLLTA-------LGEKIPDSVMGPKGVKLNISEFMDPWTKQLGYPLLNASR-INNTHIIVEQSR 577

  Fly   537 Y---VANKTDTNSAT------WYVPLNFATAN------KYDYRDTSATHYLLNVTETVISDVEAS 586
            :   ...|.:...:.      |.||:.:....      |:..|:           |.:|    ..
Worm   578 FKLLATGKEEEKYSNPVWGFKWDVPVWYQVVGSSELEMKWMKRN-----------EPLI----IK 627

  Fly   587 SDDWIIVNIQNSGYYRTLYDTQNYGLITAALKSQPWRFHPRNRAQLLYDTYIFVSTDRLSHSILL 651
            ||..:|:|.:::|:||..|.:..:..|:..||....:|.|:.|.:|:.|::.......||:||.|
Worm   628 SDKNVIINAESNGFYRAGYSSGLWKEISEMLKENHEQFSPQTRVRLIDDSFALARAGLLSYSIPL 692

  Fly   652 ELLGYLTNEQQYAPWSTA-NTILTVYDRYLRGDDSYYNFQDFVKRLIDPIFDKIGVNEIPGEHYL 715
            .|:.||.||::|.|||.| ..|..:.|.|....:     :|.|.:.:..:     ....|....:
Worm   693 NLITYLKNEKEYLPWSGAIAKIRELIDMYGSNPE-----KDIVNKFMIAL-----AENAPARRSI 747

  Fly   716 N----NYL------------RIVLVSLACQVGSDDCYNQSANKLSE----------YLYNGTAIE 754
            :    |||            :|:|.|  |..|...|........:|          .|...:.|.
Worm   748 DFVSKNYLDEKKFYEVGAAQQIILNS--CGFGDSVCQADMVKMFTEEVLAKCDATRILSECSQIP 810

  Fly   755 ATLKTQAYCAGLRSTTNEIYSRVQSDLLSSSDSTDRSLFISSLGCSGSTSQLLDFLRLSLDTNNS 819
            |..:.::||..:|:..::.:.:|.....:..:..::...:::|.||   ..:|...:|.||....
Worm   811 APFRAESYCEAVRNGNSDTFEKVFHWYKTERNQVEKLNLMTALTCS---KDILTLKKLLLDAMKP 872

  Fly   820 LSYSER---TSLLNSAYSRSEIGLTASLEFLESNWEAYANLSDSAKPLDAALRGIATYVVSEKQK 881
            ...|.|   .:.|.:..|.::....|.|.||...||      |..|.|.....|.:..
Worm   873 EGSSFRLQDCAALFAKISSNDATTDAMLNFLIDRWE------DMQKRLATDHSGFSRV------- 924

  Fly   882 TRLNALVDVVEADG---------------PSYINDDLSTTIDSRITSNFAWLEVNRDPVLNWIED 931
              |:::|:.::..|               ..:..|.:..:.:..:|    |.|.|...|...||:
Worm   925 --LSSIVNTLKTRGGLDQLRKFRKKAPKASEFGLDKMEESAEVTVT----WRETNLKFVTKIIEE 983

  Fly   932 SLK 934
            ..|
Worm   984 ISK 986

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31343	NP_732652.1	Peptidase_M1	57..446	CDD:279741	133/429 (31%)
		M1_APN_2	65..517	CDD:189008	151/502 (30%)
		ERAP1_C	591..886	CDD:288671	74/324 (23%)
anp-1	NP_001041160.1	Peptidase_M1	85..486	CDD:279741	133/430 (31%)
		M1_APN_2	93..559	CDD:189008	151/502 (30%)
		ERAP1_C	632..964	CDD:288671	77/361 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160159092
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X67
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.950