DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31343 and pam-1

DIOPT Version :9

Sequence 1:	NP_732652.1	Gene:	CG31343 / 326133	FlyBaseID:	FBgn0051343	Length:	961	Species:	Drosophila melanogaster
Sequence 2:	NP_001023210.1	Gene:	pam-1 / 177528	WormBaseID:	WBGene00003914	Length:	948	Species:	Caenorhabditis elegans

Alignment Length:	847	Identity:	237/847 - (27%)
Similarity:	397/847 - (46%)	Gaps:	108/847 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 LNSFSLILLLA-VCSLQARLILPLSLDDGQLETKGAALFATSRVDDNSA--GN-------YRLPN 60
            |.:||.|..|: |...|.|          ...|....|..|:|.:...|  ||       .|||.
Worm    28 LRNFSAIRRLSFVAGAQCR----------PYHTTANMLHRTARGEHGMAACGNPSAAVKFERLPT 82

  Fly    61 TTEPESYNVELWTNVHNGDTEFNGTVNIDIRVLNETSNITLHYRQTSNFEATII------SRDVA 119
            ..||..|||.|...::  ...|:|...||:.:...|..:.:|.:.......::|      |:.:.
Worm    83 FAEPTHYNVRLSPCLN--QFSFDGHATIDVTIKEATDVLKVHAQSLLIQSVSLITQPGDASKSLE 145

  Fly   120 T---------PTAIPLTVTPE-LQREFLVLTQTTAGEAFGANTNWTITINYTGIHRSDMGGFYIS 174
            |         ...:|.|:.|: :|.:|                      .:.|.....|.|||.|
Worm   146 TSYDDKLNILTIKLPTTMQPQKVQLDF----------------------KFVGELNDKMRGFYRS 188

  Fly   175 SYTDDDGEQHFLATTQFESTNARHAFPCYDEPARRANFTITIHHDPSYTAISNMPV-NTAATSSG 238
            .|.|.:|.:.|||:||||||.||:||||:|||..:|.|.:|:..:...||:|||.| :...|:.|
Worm   189 QYKDKNGTEKFLASTQFESTYARYAFPCFDEPIYKATFDVTLEVENHLTALSNMNVISETPTADG 253

  Fly   239 ---VTAFQTTPKMSTYLVAFIVSDFESTTGEL-NGIRQRVFSRKGKQDQQEWALWSGLLVESSLA 299
               ...|.|:||||:|||||.|.:.|..:.:. :|:..||::..||::|.:::|...:.......
Worm   254 KRKAVTFATSPKMSSYLVAFAVGELEYISAQTKSGVEMRVYTVPGKKEQGQYSLDLSVKCIDWYN 318

  Fly   300 SYFGVPFALPKLDQAGIPDFSAGAMENWGLATYREQYMWWNKQNSTINLKTNIANIIGHEYAHMW 364
            .:|.:.:.|||.|...|||||.||||||||.||||..:..:...::...|:.:|.::.||.||:|
Worm   319 EWFDIKYPLPKCDLIAIPDFSMGAMENWGLVTYREIALLVDPGVTSTRQKSRVALVVAHELAHLW 383

  Fly   365 FGDLVSIKWWTYLWLKEGFATLFSY---ESNDIAFPLWDTYQIFHVND-YNSALLNDALASAVPM 425
            ||:||::||||.||||||||:...|   .:|...|.:|    :..:|| ..|.:..|||.::.|:
Worm   384 FGNLVTMKWWTDLWLKEGFASFMEYMFVGANCPEFKIW----LHFLNDELASGMGLDALRNSHPI 444

  Fly   426 THYVQTPSEISNRYNTFSYAKPASVLYMFKNAWTDKVFRTGLNKYLTKNQYTSCDEWDLFASFQE 490
            ...:..|:|:...|::.:|||..||..|.....::.||:.||..||.:.||::....||:.:..|
Worm   445 EVEIDNPNELDEIYDSITYAKSNSVNRMLCYYLSEPVFQKGLRLYLKRFQYSNAVTQDLWTALSE 509

  Fly   491 SADELGFTLPASVDDIFSSWSHQAGYPLLTVTRNY--NAGTITITQKRYVAN-KTDTNSATWYVP 552
            ::.:       :|:::.|.|:.|.|:|:|.|::..  |...:|:.|:|:::: ..|..::.|.||
Worm   510 ASGQ-------NVNELMSGWTQQMGFPVLKVSQRQDGNNRILTVEQRRFISDGGEDPKNSQWQVP 567

  Fly   553 LNFATANKYDYRDTSATHYLLNVTETVISDVEASSDDWIIVNIQNSGYYRTLYDTQNYGLITAAL 617
            :..|..:...  |..| .:||...:...:....:..:|:.:|...:|:||..|..:   ::||.|
Worm   568 ITVAVGSSPS--DVKA-RFLLKEKQQEFTIEGVAPGEWVKLNSGTTGFYRVEYSDE---MLTAML 626

  Fly   618 KSQPWRFHP-RNRAQLLYDTYIFVSTDRLSHSILLELLGYLTNEQQYAPWSTANTILTVYDRYLR 681
            .....|..| .:|..|:.|....::|.|:|.:..:::......|.:|..|...:..::......|
Worm   627 PDIASRRMPVLDRFGLINDLSALLNTGRVSIAQFVQVAASSAKEDEYVVWGAIDEGMSKLLACAR 691

  Fly   682 --GDDSYYNFQDFVKRLIDPIFDKIGVNEIPGEHYLNNYLRIVLVSLACQVGSDDCYNQSANKLS 744
              .:|:..:.:..|.::.:....::|..|..||......||.::.:...:.|.....::.....:
Worm   692 EMSEDTLKSAKQLVVKMFEQTGAELGFAEQAGEDSQKMMLRSLVQARLARAGHQPTIDKFTQMFN 756

  Fly   745 EYLYNGTAIE-----ATLKTQAYCAG---------LRSTTNEIYSRVQSDLLSSSDSTDRSLFIS 795
            ::|..||.|.     ||....|...|         ||.||.  :..::...:.:...|.....::
Worm   757 DFLEKGTPIHPDIRLATFGVVARYGGKEGFDKLMNLRETTT--FQEIERQTMVAMSQTPEESLLA 819

  Fly   796 SL 797
            .|
Worm   820 QL 821

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31343	NP_732652.1	Peptidase_M1	57..446	CDD:279741	141/413 (34%)
		M1_APN_2	65..517	CDD:189008	157/476 (33%)
		ERAP1_C	591..886	CDD:288671	43/224 (19%)
pam-1	NP_001023210.1	M1_APN_2	87..529	CDD:189008	157/476 (33%)
pam-1	NP_001023210.1	ERAP1_C	602..927	CDD:314669	44/225 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S1087
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X67
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.970