DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31343 and ltah-1.2

DIOPT Version :9

Sequence 1:	NP_732652.1	Gene:	CG31343 / 326133	FlyBaseID:	FBgn0051343	Length:	961	Species:	Drosophila melanogaster
Sequence 2:	NP_500385.1	Gene:	ltah-1.2 / 177123	WormBaseID:	WBGene00022610	Length:	625	Species:	Caenorhabditis elegans

Alignment Length:	652	Identity:	132/652 - (20%)
Similarity:	228/652 - (34%)	Gaps:	148/652 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    84 GTVNIDIRVLNETSNITLHYRQTSNFEATI--------ISRDVAT--PTAIPLTVTPELQREFLV 138
            |...:..|.|.:.:.:.|..|..|....:|        |:.:|.|  .:.:.:.:.|:.|:...:
Worm    42 GQATLRCRCLTDATKLVLDVRDLSIRSVSINGVDCDFRIAPNVYTFFGSKMSVYLPPQFQKAGTI 106

  Fly   139 LTQTTAGEAFGANTNWTITINYTGIHRSDMGGFYISSYTDDDGEQHFLATTQFESTNARHAFPCY 203
            |..|.   |:|.:.:.|..........:|....|:.|              |.::.:||...||.
Worm   107 LQVTV---AYGTSPDATALQWMKKEQTADKRMPYLFS--------------QCQAIHARSIVPCM 154

  Fly   204 DEPARRANFTITIHHDPSYTAISNMPVNTAATSSG-------VTAFQTTP-KMSTYLVAFIVSDF 260
            |.|:.::.:      :...|..:.|....:|...|       .|.|...| .:.:||:|.:|...
Worm   155 DTPSVKSTY------EAEVTVPTGMTCLMSAIGQGSKGDDDTTTFFYKQPVAIPSYLIAIVVGCL 213

  Fly   261 ESTTGELNGIRQR--VFSRKGKQDQQEWALWSGLLVESSLASYFGV--PFALPKLDQAGI-PDFS 320
            |.     ..|..|  |::.....|:..|....   .|..|||...:  .:...:.|...: |.|.
Worm   214 EK-----RDISDRCAVWAEPSVVDKAHWEFAE---TEDILASAEEIAGKYIWGRYDMVCLPPSFP 270

  Fly   321 AGAMENWGLATYREQYMWWNKQNSTINLKTNIANIIGHEYAHMWFGDLVSIKWWTYLWLKEGFAT 385
            .|.|||..|.......:..::         ::.::|.||.||.|.|:||:...|.:.||.||| |
Worm   271 FGGMENPCLTFLTPTLIAGDR---------SLVSVIAHEIAHSWSGNLVTNSSWEHFWLNEGF-T 325

  Fly   386 LFSYESNDIAFPLWDTYQIFHVNDYNSALLNDALASAVPMTHYVQTPSEISN-----RYNTFSYA 445
            :|............|..|....|.:.::|:........|...:.:...:.:|     .::...|.
Worm   326 MFIERKICGRLVSEDYRQFMAFNGWTNSLIPAVYEQFTPTHQFTKLIQDHTNVDPDVAFSCVPYE 390

  Fly   446 KPASVL-YMFKNAWTDKVFRTGLNKYLTKNQYTSCDEWD-------LFASFQESADELGFTLPAS 502
            |.:::| |:.:.....::|...|..||....:.:.|.|.       .||..:|..|.:.|.|
Worm   391 KGSALLFYLEQKLGGSEIFEAYLKDYLKTFAHQAIDSWQWKDHLYKYFADQKEVLDTVNFDL--- 452

  Fly   503 VDDIFSSWSHQAGYPLLTVTRNYNAGTI----TITQKRYVANKT---DTNSATWYV--PL-NFAT 557
                   |.:..|.|  ....||....:    .:.:|...|:::   |..|..:|.  || ....
Worm   453 -------WFNGVGMP--PEKPNYGQSMVEACEVLLKKWLAADESTVGDITSEDYYAMQPLQQIEL 508

  Fly   558 ANKYDYRDTSATHYLLNVTETVISDVEASSDDWIIVNIQNSGYYRTLYDTQNYGL----ITAALK 618
            .::....|....||.|:....:                     |: |.|:||..|    :...:|
Worm   509 LSQLWQHDPPIEHYKLDALNKL---------------------YK-LNDSQNSELLLNWLRLCIK 551

  Fly   619 SQPWRFHPRNRAQLLYDTYIFVSTD---RLSHSILLELLGYLTNEQQYAPWSTANTILTVYDRYL 680
            |: |.       :.:.....||::.   :....|..:|          |.|..||.  ...|.||
Worm   552 SK-WE-------ECIPKALDFVNSQGRLKFCRPIYRDL----------AQWPIANK--KARDVYL 596

  Fly   681 RG 682
            :|
Worm   597 KG 598

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31343	NP_732652.1	Peptidase_M1	57..446	CDD:279741	80/389 (21%)
		M1_APN_2	65..517	CDD:189008	97/468 (21%)
		ERAP1_C	591..886	CDD:288671	21/99 (21%)
ltah-1.2	NP_500385.1	M1_LTA4H	12..455	CDD:341062	96/463 (21%)
ltah-1.2	NP_500385.1	Leuk-A4-hydro_C	500..614	CDD:378127	27/141 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910