DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31343 and T16G12.1

DIOPT Version :9

Sequence 1:	NP_732652.1	Gene:	CG31343 / 326133	FlyBaseID:	FBgn0051343	Length:	961	Species:	Drosophila melanogaster
Sequence 2:	NP_499230.2	Gene:	T16G12.1 / 176416	WormBaseID:	WBGene00011803	Length:	1890	Species:	Caenorhabditis elegans

Alignment Length:	1083	Identity:	272/1083 - (25%)
Similarity:	422/1083 - (38%)	Gaps:	252/1083 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 ILPLSLD----DGQLETKGAALFATSRVDDNSAGNYRLPNTTEPESYNVE--LWTNVH------- 76
            |||...|    |.....|..:|:.|..         |||    |..|.::  ||...:
Worm    53 ILPEHPDNFRQDKLAARKRQSLYVTKT---------RLP----PNLYAIDYSLWFQPYFPSPGVQ 104

  Fly    77 ---NGDTEFNGTVNIDIRVLNETSNITLHYRQTSNFEA---TIISRDVATPTAIPL-TVTPELQR 134
               ..:..|:|..:|.:..|..:....|:   ..||:.   .::..|   .|.:|: :::.:...
Worm   105 YAPEKNFTFDGRASIQVEALVASDRFILN---AYNFKIQSYKVVDID---GTVVPINSISQDDTT 163

  Fly   135 EFLVLTQTTAGEAFGANTNWTITINYTGIHR--SDMGGFYISSYTDDDGEQHFLATTQFESTNAR 197
            :.|.|.....|...|...|  |...||||..  :| ||.|.:||.|..|..|::..|..|..:||
Worm   164 QQLSLITNANGVVAGQIYN--IEFVYTGIINPYTD-GGVYYTSYNDPQGNTHYMIATHMEPFSAR 225

  Fly   198 HAFPCYDEPARRANFTITIHHDPSYTAISNMPVNTAATS-----SGVTAFQTTPKMSTYLVAFIV 257
            ..||..|||:.:|.||||:.:..|..|:||| :.|..|.     |.:| |..|||||:||:||.|
Worm   226 KVFPSLDEPSYKAKFTITVQYPASQVALSNM-METEPTKIDNIWSTIT-FPQTPKMSSYLIAFAV 288

  Fly   258 SDF-ESTTGELNGIRQRVFSRKGKQDQQEWALWSGLLVESSLASYFGVPFALPKLDQAGIPDFSA 321
            ..: .|.....:....|.:...|.:...::|..:.......|..|.|:.|.|.|.||.|:|:|.|
Worm   289 GPYVNSQYVNKHNTLTRAWGWPGTEQYLQFAAQNAGECLYQLGEYTGIKFPLSKADQLGMPEFLA 353

  Fly   322 GAMENWGLATYREQYMWWNKQNSTINLKTNIANIIGHEYAHMWFGDLVSIKWWTYLWLKEGFATL 386
            ||||||||..|:.||:.:|....|.......|.::.||.||.||||||:..||..|:|.||||..
Worm   354 GAMENWGLIIYKYQYIAYNPTTMTTRNMEAAAKVMCHELAHQWFGDLVTTAWWDDLFLNEGFADY 418

  Fly   387 FSYESNDIAFP----LWDTYQIFHVNDYNSALLNDALASAVPMTHYVQTPSEISNRYNTFSYAKP 447
            |........:|    ..||.|:  :::....|..|....|.|:. |...|:     ::..:|.|.
Worm   419 FMTFIQKSVYPQQATYLDTLQV--LDELQVGLTADVRYDAHPLV-YPDGPA-----FDDITYNKG 475

  Fly   448 ASVLYMFKNAWTDKVFRTGLNKYLTKNQYTSCDEWDLFASFQESA------DELGFTLPASVDDI 506
            ||:|.|..:.....||:.|:..||.|.||::.:::|||::..::|      |..|  ||.:|.|.
Worm   476 ASMLRMLSDVLGADVFKQGIRAYLQKMQYSNANDFDLFSTLTDTAKSNNILDWCG--LPLNVTDF 538

  Fly   507 FSSWSHQAGYPLLTVTRNYNAGTITITQKRY--VANKTDTN-SATWYVPL---NFATANKYDY-- 563
            ...:.||..:||:....|...|..|.:|:.:  :::.|.|. :.||.:||   |...|:.|..
Worm   539 MQPYIHQTNHPLIRYNNNQKIGGSTFSQEPFLDISDLTATPWNYTWSIPLTSANLRHADPYKQWL 603

  Fly   564 -RDTSATHYLLNVTETVISDVEASSDDWIIVNIQNSGYYRTLYDTQNYGLITAALKSQPWRFHPR 627
             |.....:...|:.|..|.:....:..|.:.:|.::.|.|.:||...:..|...:|...  .:..
Worm   604 PRQQGCANMNENIQEERIKEPNKRAVQWELTSITSATYGRIIYDDIGFDRILKLIKQDD--INDN 666

  Fly   628 NRAQLLYDTYIFVSTDR-----LSHSILLELLGYL------TNEQQYAPWSTANTIL-TVYDRYL 680
            .:..||.|.|.::..::     ..::..|:|...:      ||...|..::.|..:| .:...|.
Worm   667 LKLTLLADEYNYMLREKKANRPFGYNRFLDLAKVIFNTQSFTNYPSYGVFAQAQPVLEQIAQLYR 731

  Fly   681 RGDDSYYNFQDFVKRLIDPIFDKIGVNEIPGEHYLNNYLRI---------------VLVSLACQV 730
            .|.|:     :||.||....|.             |:|.::               |.:..|.:.
Worm   732 DGIDA-----EFVPRLYKLFFQ-------------NSYNQLKWQDTSIWDTDTFSEVFLPFAVRY 778

  Fly   731 GSDDCYNQSANKLSEY------LYNGTA----IEATLKTQAYCAGLRSTTNEIYSRVQSD----L 781
            ...|..|::.|..:..      ..||||    ....|:...||...:      |:...||    :
Worm   779 DIGDVQNRTLNMFANVKSACINSLNGTAWCNPYSTNLRKAIYCGAAK------YAPATSDYFFQM 837

  Fly   782 LSSSDS---------TDRSLFISSLGCSGSTSQLLDFLRL-SLDTNNS------LSYSERTS--- 827
            |.|.:.         .:....:..:.|:.|.:.|...:|| :..|.|.      |.|:...|
Worm   838 LHSYNKEVITNPYFYQEYMALLEGMSCTQSPATLKVLIRLFTTSTLNPSTIFGFLKYNPAASDVL 902

  Fly   828 ---------LLNSAYSRSEIGLTASLEFLESNWEAY---ANLSDSAKPLDAALRGIATYVVSEKQ 880
                     |:||..      |.|.|:.:..||.:|   ..||.....|
Worm   903 YNYFMANPQLVNSTM------LDAYLDAMTYNWNSYFREGQLSTLMNTL---------------- 945

  Fly   881 KTRLNALVDVVEADGPSYINDDLSTTIDSRITSNFAWLEVNRDPVLNWIEDSL------------ 933
             |..|...|:.:    .|||         |::..|.:......|..||:.|:|
Worm   946 -TLTNDQFDIFD----FYIN---------RVSLMFEYKSTYALPTYNWLYDNLVVIGKTPWEKTP 996

  Fly   934 -------------------------KENGSPSLTSSITTILVS 951
                                     .||.:.|.||::|..|||
Worm   997 NIDAVFPYYKLDLQVNIPGSGPYQWYENMTFSATSTVTFQLVS 1039

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31343	NP_732652.1	Peptidase_M1	57..446	CDD:279741	130/416 (31%)
		M1_APN_2	65..517	CDD:189008	151/485 (31%)
		ERAP1_C	591..886	CDD:288671	68/366 (19%)
T16G12.1	NP_499230.2	M1_APN_2	88..549	CDD:189008	150/481 (31%)
		ERAP1_C	640..931	CDD:314669	62/322 (19%)
		Peptidase_M1	999..1402	CDD:279741	9/41 (22%)
		ERAP1_C	1542..1839	CDD:314669
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0308
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.920