DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31343 and Y53F4B.20

DIOPT Version :9

Sequence 1:	NP_732652.1	Gene:	CG31343 / 326133	FlyBaseID:	FBgn0051343	Length:	961	Species:	Drosophila melanogaster
Sequence 2:	NP_497105.3	Gene:	Y53F4B.20 / 175160	WormBaseID:	WBGene00013166	Length:	694	Species:	Caenorhabditis elegans

Alignment Length:	726	Identity:	151/726 - (20%)
Similarity:	248/726 - (34%)	Gaps:	204/726 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MARWLLNSFSLILLLAVCSLQARLIL---PLSLDDGQLETKGAALFATSRVDDNSAGNYRLPNTT 62
            |..||     |:.|..:.:.....:|   ||..||                        |||...
Worm     1 MIPWL-----LLYLFGIVTSDLHQLLSTRPLYSDD------------------------RLPPIL 36

  Fly    63 EPESYNVEL---WTNVHNGD----------------------------TEFNGTVNIDIRVLNET 96
            :|.||:::|   .:.|.:.|                            |.....:..||.:|:..
Worm    37 KPLSYDLQLQLPLSEVSDPDVPLFTGRCVMHFEINQQIGPESAFISDSTSNRARIKFDIIMLDHF 101

  Fly    97 SNITL----HYRQTSNFEATIISRDVAT--PTAIPLTVTPELQREFLVLTQTTAGEAFGANTNWT 155
            .|::|    |..:..|.:.|..|.:::.  |...|                          ..:|
Worm   102 ENVSLVMNGHELEIFNVQLTDDSMELSVDQPVLFP--------------------------GRYT 140

  Fly   156 ITIN-YTGIHRSDMGGFYISSYTDDDGEQHFLATTQFESTNARHAFPCYDEPARRANFTITIHHD 219
            :||: |.|:..|       :.|..|.||.....:..|.: .|...||.|.....:..|:||:.|
Worm   141 LTIHRYKGLIGS-------AIYYRDAGEHAVFGSNLFPN-RAPAVFPSYLASTEKVTFSITMVH- 196

  Fly   220 PSYTAISNMPVNTAATSSG--------------VTAFQTTPKMSTYLVAFIVSDFESTTGE--LN 268
                     ||.|.|.:||              :|.|.|||.::..::.|::...|.|..|  ..
Worm   197 ---------PVGTLALTSGSNEGAPRKIDENWQMTTFSTTPSITPSMLCFLLLPHEYTHIESTYT 252

  Fly   269 GIRQRV-FSR-KGKQDQQEWALWSGLLVESSLASYFGVPFALPKLDQAGIPDFSAGAMENWGLAT 331
            |:...| ::| :.:::|.:..|.:...|.:.|...|.....:||:|...:.:.|:.|.  :|...
Worm   253 GVNISVHYNRFRVQKEQTKHLLHTATQVLALLKDIFSSLIPVPKIDIITMNEVSSTAC--FGSIV 315

  Fly   332 YRE-QYMWWNKQNSTINLKTNIANIIGHEYAHMWFGDLVSIKWWTYLWLKEGFATLFSYE----- 390
            ..| |:...:..|....|.|.:|.        .|.|...:|...:.|.|:|......:.:
Worm   316 VSEVQFFSADYANQVKMLATWLAK--------QWIGGYAAISEGSELCLQEDLVAFIADKVIKRM 372

  Fly   391 SNDIAFPLWDTYQIFHVNDYNSALLNDALASAVPMTHYVQTPSEISNRYNTFSYA--KPASVLYM 453
            :||....|....:|:         |::.:.:|.......:.|    |.:..|...  |..::|..
Worm   373 TNDEFTRLGHLAKIY---------LSETIFTAGDTLKLDEHP----NEFEIFEKCGLKGVAMLES 424

  Fly   454 FKNAWTDKVFRTGLNKYLTKNQYTSCDEWDLFASFQESADELGFTLPASVDDIFSS-----WSHQ 513
            .::...:|...:.:|:.:..::..|.....|:.....:.||          ||:.|     |...
Worm   425 IESLIGEKSMISKINEMIYNSKKGSYSSRTLYGLLNSTVDE----------DIYVSQLLHYWHEH 479

  Fly   514 AGYPLLTVTRNYNAGTITITQKRYVANKTDTNSA-------TWYVPLNFATANKYDYRDTSATHY 571
            .|.|.:.|.|  .|.:|.|||..  :|.|..|.|       .|.:||.|             |.:
Worm   480 GGLPYMNVDR--LANSIKITQNG--SNMTVKNGAGTWERMPLWPLPLKF-------------TEF 527

  Fly   572 LLNVTETVISDVEAS--SDDWIIVNIQNSGYYRTLYDTQNYGLITAALKSQPWRFHPRNRAQLLY 634
            .|.:...|...:..|  .|..|..|:..:.|||..||...:..|...|......:..|.|.||:.
Worm   528 KLPIQIMVSHGIHLSPIRDGLIFSNLGFTNYYRVNYDIDTWREIKTVLTENATSYTLRERFQLVS 592

  Fly   635 DTYIFVSTDRL 645
            |...|.|...|
Worm   593 DFCYFYSIKSL 603

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31343	NP_732652.1	Peptidase_M1	57..446	CDD:279741	90/452 (20%)
		M1_APN_2	65..517	CDD:189008	99/520 (19%)
		ERAP1_C	591..886	CDD:288671	17/55 (31%)
Y53F4B.20	NP_497105.3	GluZincin	39..>300	CDD:301352	62/304 (20%)
Y53F4B.20	NP_497105.3	ERAP1_C	552..>593	CDD:288671	12/40 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0308
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.910