DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31343 and F49B2.6

DIOPT Version :9

Sequence 1:	NP_732652.1	Gene:	CG31343 / 326133	FlyBaseID:	FBgn0051343	Length:	961	Species:	Drosophila melanogaster
Sequence 2:	NP_493503.2	Gene:	F49B2.6 / 173297	WormBaseID:	WBGene00009865	Length:	1082	Species:	Caenorhabditis elegans

Alignment Length:	906	Identity:	234/906 - (25%)
Similarity:	426/906 - (47%)	Gaps:	81/906 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    57 RLPNTTEPESYNVELWTNVHNGDTEFNGTVNIDIRVLNETSNITLHYRQTSNFEATIISRDVATP 121
            |||.|.||..|::.|..|:.||:.|  .:|:|.|.:.|:|..:.|:   ..|.|  :.|.|:...
Worm   199 RLPRTAEPIDYDLTLHPNLTNGEVE--ASVSIRILIKNDTKLLILN---AENLE--MKSFDITKK 256

  Fly   122 TAIPLTVTPELQREFL---VLTQTT--AGEAFGANTNWTITINYTGIHRSDMGGFYISSYTDDDG 181
            .|       :::.:|:   |:||..  ..:......:..:||.|:...:||:.|.|.|::...||
Worm   257 GA-------KVKADFVKCAVMTQWAWKLAKRLHKGDHIVLTIYYSAQMKSDLQGLYFSTHLGTDG 314

  Fly   182 EQHFLATTQFESTNARHAFPCYDEPARRANFTITIHHDPSYTAISNMPVNTAAT-SSGV--TAFQ 243
            ::...|.||||.|.||...||:|||..:|.|.:.|..:|.:.|.|||.:..:.. .:|:  ..|:
Worm   315 KKTKSAATQFEPTFARKMLPCFDEPNFKATFQVAIIRNPHHIARSNMNILISKEYKNGLIKDVFE 379

  Fly   244 TTPKMSTYLVAFIVSD-----FESTTGELNGIRQRVFSRKGKQD----QQEWALWSGLLVESSLA 299
            .:.||||||:|..|.|     ...|......|..|:::   .||    |.|:.|.:.:.......
Worm   380 KSVKMSTYLLAVAVLDGYGYIKRLTRNTQKAIEVRLYA---PQDMLTGQSEFGLDTTIRALEFFE 441

  Fly   300 SYFGVPFALPKLDQAGIPDFSAGAMENWGLATYREQYMWWNKQNSTINLKTNIANIIGHEYAHMW 364
            .||.:.:.|.|:|...:.|||.||||||||.|:|:..:.:|::.:::..|.:||.||.||.||.|
Worm   442 DYFNISYPLDKIDLLALDDFSEGAMENWGLVTFRDSALLFNERKASVVAKEHIALIICHEIAHQW 506

  Fly   365 FGDLVSIKWWTYLWLKEGFATLFSYESNDIAFPLWDTYQIFHVNDYNSALLNDALASAVPMTHYV 429
            ||:||::.||..::|.||||....|:..:..||.|.....|:..:...:...|...|    :..:
Worm   507 FGNLVTMDWWNEVFLNEGFANYMEYKCVEHLFPDWSIMSRFYAENLAFSQEPDGFLS----SRAI 567

  Fly   430 QTPSEIS--NRYNTFSYAKPASVLYMFKNAWTDKVFRTGLNKYLTKNQYTSCDEWDLFASFQESA 492
            ::..:.|  |.::..:|.|.|::::|.......|.|:..|.:||.|..|::....||:...::.|
Worm   568 ESDDDDSLLNLFDAINYHKAAAIIHMIAEMAGQKNFQNALVEYLNKYAYSNAIGVDLWKIVEKHA 632

  Fly   493 DELGFTLPASVDDIFSSWSHQAGYPLLTVTRNYNAGTITITQKRYV---ANKTDTNSATWYVPLN 554
            :..|   ..|:.|:..:::.|.|||||||.|. :.|.:...|.|::   .:|.:.....|..|:.
Worm   633 NLQG---TVSIPDLAKAYTTQVGYPLLTVERT-DEGVLVHNQTRFLFAEGDKAEEKRGDWKWPIP 693

  Fly   555 FATANKYDYRDT----SATHYL----LNVTETVISDVEASSDDWIIVNIQNSGYYRTLYDTQNYG 611
            .:      |||:    ...|::    .|||      .|.:|:||:|:|....||::.|||.:.|.
Worm   694 IS------YRDSEHRRKKQHWIQADDKNVT------WETTSNDWLILNTGGVGYFKVLYDPETYR 746

  Fly   612 LITAALKSQPWRFHPRNRAQLLYDTYIFVSTDRLSHSILLELLGYLTNEQQYAPWSTANTILTVY 676
            .:...|:.......|.:|:.:|.|::....|..|:.|:..:||.|:..|.....||.....|...
Worm   747 KLVKQLQRNHTTISPIDRSMILVDSFDLSKTSLLNISVYFDLLEYVEKETDKMTWSIVGKQLRTI 811

  Fly   677 DRYLRGDDSYYNFQDFVKRLIDPIFDKIGVNEIPGEHYLNNYLRIVLVSLACQVGSDDCYNQSAN 741
            :..:...|....:|||.:.||..:::.:..:| .|.:.....|::.:.::||::...||..|:..
Worm   812 EALIEESDYLDIYQDFQRSLIMRLYESLDWDE-QGANPNQKRLQVDIFAVACRLQIKDCTKQAYQ 875

  Fly   742 KLSEYLYNGTAIEATLKTQAYCAGLRSTTNEIYSRVQSDLLSSSDSTDRSLFISSLGCSGSTSQL 806
            :..:::.:|.. .......|...|::......:.|:.....:::..::::..|.:|..:...|.:
Worm   876 RYLQWVSSGVR-NPEHHMIALMEGVKQGETTAWERIWKAYKTATSPSEKNNIIGALTSTKDASLI 939

  Fly   807 LDFLRLSLDTNNSLSYSERTSLLNSAYSRSEIGLTASLEFLESNWEAYANLSDSAKPLDAALRGI 871
            ...|:..||.....:...|   :.|.:|.::.......:|.::::|.:..:......:.:.::.:
Worm   940 NRLLKYCLDGKIKANLIPR---VFSYFSLNQSTRNIVWKFFKTHFEQFHGILGKGSLMASCVKCL 1001

  Fly   872 ATYVVSEKQKTRLNALVDVVEADGPSYINDDL---STTIDSRITSNFAWLEVNRDPVLNWI 929
            |..:.:|   |.|..:.:.:::.  .:..|.|   ..|.: :|..|..|.::|...:..||
Worm  1002 AEPLSTE---TELEEVKEFLKSQ--KFAEDGLIKMEMTYE-QIELNIQWRKLNEGQLGKWI 1056

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31343	NP_732652.1	Peptidase_M1	57..446	CDD:279741	127/407 (31%)
		M1_APN_2	65..517	CDD:189008	139/470 (30%)
		ERAP1_C	591..886	CDD:288671	56/294 (19%)
F49B2.6	NP_493503.2	Peptidase_M1	199..586	CDD:279741	127/407 (31%)
		M1_APN_2	207..654	CDD:189008	139/470 (30%)
		ERAP1_C	726..1037	CDD:288671	59/321 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0308
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X67
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.920