DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31343 and Lnpep

DIOPT Version :9

Sequence 1:	NP_732652.1	Gene:	CG31343 / 326133	FlyBaseID:	FBgn0051343	Length:	961	Species:	Drosophila melanogaster
Sequence 2:	NP_001106874.1	Gene:	Lnpep / 171105	RGDID:	621752	Length:	1025	Species:	Rattus norvegicus

Alignment Length:	974	Identity:	269/974 - (27%)
Similarity:	449/974 - (46%)	Gaps:	131/974 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 LILLLAVCSL----------QARLILPLSLDDGQLETKGAALFATSRVDDNSAGNYRLPNTTEPE 65
            :|.||..|:.          .|.||.|::       |.| .:|..:::        |||....|:
  Rat   127 VIYLLPRCTFTKEGCHKTNQSAELIQPIA-------TNG-KVFPWAQI--------RLPTAIIPQ 175

  Fly    66 SYNVELWTNVHNGDTEFNGTVNIDIRVLNETSNITLHYRQTSNFEATIISRDVATPTAIPLTVTP 130
            .|.:.|..|:.:  ..|.|:|.|.::.|.:|.:|.||          ....::::.|.:....:.
  Rat   176 RYELSLHPNLTS--MTFRGSVTISLQALQDTRDIILH----------STGHNISSVTFMSAVSSQ 228

  Fly   131 ELQREFLVL-----TQTTAGEAFGANTNWTITINYTGIHRSDMGGFYISSYTDDDGEQHFLATTQ 190
            |.|.|.|..     ....|.|:.....|:|:.|.|:....:...|||..:|||...|:...|.||
  Rat   229 EKQVEILEYPYHEQIAVVAPESLLTGHNYTLKIEYSANISNSYYGFYGITYTDKSNEKKNFAATQ 293

  Fly   191 FESTNARHAFPCYDEPARRANFTITIHHDPSYTAISNMPVNTAA-TSSGV--TAFQTTPKMSTYL 252
            ||...||.||||:||||.:|.|.|.|..|..:||:||||..::. |..|:  ..|..:.||||||
  Rat   294 FEPLAARSAFPCFDEPAFKATFIIKITRDEHHTALSNMPKKSSVPTEEGLIQDEFSESVKMSTYL 358

  Fly   253 VAFIVSDFESTTGELNGIRQRVFSRKGKQDQQEWALWSGLLVESSLASYFGVPFALPKLDQAGIP 317
            |||||.:..:.:.::||....|::...|.||...||.:.:.:.....:||.:.:.|.|||...||
  Rat   359 VAFIVGEMRNLSQDVNGTLVSVYAVPEKIDQVYHALDTTVKLLEFYQNYFEIQYPLKKLDLVAIP 423

  Fly   318 DFSAGAMENWGLATYREQYMWWNKQNSTINLKTNIANIIGHEYAHMWFGDLVSIKWWTYLWLKEG 382
            ||.|||||||||.|:||:.:.::...|::..:..:..||.||.||.|||:||:::||..|||.||
  Rat   424 DFEAGAMENWGLLTFREETLLYDNATSSVADRKLVTKIIAHELAHQWFGNLVTMQWWNDLWLNEG 488

  Fly   383 FATLFSYESNDIAFPLWDTYQIFHVNDYNSALLNDALASAVPMTHYVQTPSEISNRYNTFSYAKP 447
            |||...|.|.:..|...::|:.| ::.....:..|:|.|:.|::..||:..:|...:::.||.|.
  Rat   489 FATFMEYFSVEKIFKELNSYEDF-LDARFKTMRKDSLNSSHPISSSVQSSEQIEEMFDSLSYFKG 552

  Fly   448 ASVLYMFKNAWTDKVFRTGLNKYLTKNQYTSCDEWDLFASFQESADELGFTLPASVDDIFSSWSH 512
            ||:|.|.|:..::.||:..:..||..:.|.:....||:.||.|..   |.||  .|..:..:|:.
  Rat   553 ASLLLMLKSYLSEDVFQHAIILYLHNHSYAAIQSDDLWDSFNEVT---GKTL--DVKKMMKTWTL 612

  Fly   513 QAGYPLLTVTRNYNAGT-ITITQKRYVAN------KTDTNSATWYVPLNFAT--ANKYDYRDTSA 568
            |.|:||:||.|.   || :.:.|:|:..:      .:|| |..|::|:::.|  .|..:||..|.
  Rat   613 QKGFPLVTVQRK---GTELLLQQERFFPSMQPEIQDSDT-SHLWHIPISYVTDGRNYSEYRSVSL 673

  Fly   569 THY---LLNVTETVISDVEASSDDWIIVNIQNSGYYRTLYDTQNYGLITAALKSQPWRFHPRNRA 630
            ...   ::|:||.|         .|:.||...:|||...|....:..:...||..|:....::||
  Rat   674 LDKKSDVINLTEQV---------QWVKVNTNMTGYYIVHYAHDGWAALINQLKRNPYVLSDKDRA 729

  Fly   631 QLLYDTYIFVSTDRLSHSILLELLGYLTNEQQYAPWSTANTILTVYDRYLRGDDSYYNF------ 689
            .|:.:.:......::...:..:|:.||.||...||.:.|          |...|..||.
  Rat   730 NLINNIFELAGLGKVPLQMAFDLIDYLRNETHTAPITEA----------LFQTDLIYNLLEKLGH 784

  Fly   690 QDFVKRLIDPIFDKIGVNEIPGEHYLN------NYLRIVLVSLACQVGSDDCYNQSANKLSEYL- 747
            .|...||:..: .|:..|:|..:.:.:      ..||..|:..||....::|...:......::
  Rat   785 MDLSSRLVTRV-HKLLQNQIQQQTWTDEGTPSMRELRSALLEFACAHSLENCTTMATKLFDGWMA 848

  Fly   748 YNGT-AIEATLKTQAYCAGLRSTTN-----EIYSRVQSDLLSSSDSTDRSLFISSLGCSGSTSQL 806
            .||| ::...:.|..:..|.|:...     .:||.:.|:       .::...:.:|..|....:|
  Rat   849 SNGTQSLPTDVMTTVFKVGARTEKGWLFLFSMYSSMGSE-------AEKDKILEALASSADAHKL 906

  Fly   807 LDFLRLSLDTNNSLSYSERTSLLNSAYSRSEIGLTASLEFLESNWEAYANLSDSAKPLDAALRGI 871
            ...::.|||  ..:..:::.||:.....|...|...:.:|::.||....:..........::...
  Rat   907 YWLMKSSLD--GDIIRTQKLSLIIRTVGRQFPGHLLAWDFVKENWNKLVHKFHLGSYTIQSIVAG 969

  Fly   872 ATYVVSEKQKTRLNALVDVVEADGPSYINDDLSTTIDSR-ITSNFAWLEVNRDPVLNWIEDSLK 934
            :|::.|  .||.|:.:.:        :..:....|:..| :...|..:|:|    :.|:..:||
  Rat   970 STHLFS--TKTHLSEVQE--------FFENQSEATLQLRCVQEAFEVIELN----IQWMARNLK 1019

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31343	NP_732652.1	Peptidase_M1	57..446	CDD:279741	140/396 (35%)
		M1_APN_2	65..517	CDD:189008	159/459 (35%)
		ERAP1_C	591..886	CDD:288671	63/313 (20%)
Lnpep	NP_001106874.1	Dileucine internalization motif. /evidence=ECO:0000255	53..54
		Dileucine internalization motif. /evidence=ECO:0000255	76..77
		Tankyrase binding. /evidence=ECO:0000250	96..101
		Peptidase_M1	167..552	CDD:279741	140/397 (35%)
		M1_APN_2	176..617	CDD:189008	159/458 (35%)
		Substrate binding. /evidence=ECO:0000250	428..432		3/3 (100%)
		ERAP1_C	690..1005	CDD:288671	65/344 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166349283
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0308
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X67
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.850