Protein Alignment CG31343 and Lta4h

DIOPT Version :9

• Sequence 1: NP_732652.1
• Gene: CG31343 / 326133
• FlyBaseID: FBgn0051343
• Length: 961
• Species: Drosophila melanogaster
• Sequence 2: NP_032543.2
• Gene: Lta4h / 16993
• MGIID: 96836
• Length: 611
• Species: Mus musculus
• Alignment Length: 541
• Identity: 126/541 - (23%)
• Similarity: 206/541 - (38%)
• Gaps: 117/541 - (21%)

  Fly   101 LHYRQTSNFEATIISRDVATPTAIPLTV-------------TPELQREFLVL----TQTTAGE-- 146
            ||.|.:.:|     :|...|.|| .|||             |.:|..|.:|:    .:.|.||
Mouse    22 LHLRCSVDF-----ARRTLTGTA-ALTVQSQEENLRSLTLDTKDLTIEKVVINGQEVKYTLGESQ 80

  Fly   147 -------------AFGANTNWTITINYTGIHRSDMGGFYISSYTDDDGEQHFLATTQFESTNARH 198
                         |...|....|.|::....:|....:.....|  .|:||....:|.::.:.|.
Mouse    81 GYKGSPMEISLPIALSKNQEIVIEISFETSPKSSALQWLTPEQT--SGKQHPYLFSQCQAIHCRA 143

  Fly   199 AFPCYDEPARRANFTITIHHDPSYTAISNMPVNTAATSSGVT---------------AFQTTPKM 248
            ..||.|.|:.:.          :|||..::|....|..|.:.               .|.....:
Mouse   144 ILPCQDTPSVKL----------TYTAEVSVPKELVALMSAIRDGEAPDPEDPSRKIYRFNQRVPI 198

  Fly   249 STYLVAFIVSDFESTTGELNGIRQRVFSRKGKQDQ--QEWALWSGLLVESSLASYFGVPFALPKL 311
            ..||:|.:|...||   ...|.|..|:|.|.:.::  .|::....:|   .:|...|.|:...:.
Mouse   199 PCYLIALVVGALES---RQIGPRTLVWSEKEQVEKSANEFSETESML---KIAEDLGGPYVWGQY 257

  Fly   312 DQAGI-PDFSAGAMENWGLATYREQYMWWNKQNSTINLKTNIANIIGHEYAHMWFGDLVSIKWWT 375
            |...: |.|..|.|||..|.......:..:|         :::|:|.||.:|.|.|:||:.|.|.
Mouse   258 DLLVLPPSFPYGGMENPCLTFVTPTLLAGDK---------SLSNVIAHEISHSWTGNLVTNKTWD 313

  Fly   376 YLWLKEGFATLFSYESNDIAFPLW-DTYQIFHVNDYNSALLN--DALASAVPMTHYVQTPSEISN 437
            :.||.||...   |....|...|: :.::.||.......|.|  .....:.|.|..|....::..
Mouse   314 HFWLNEGHTV---YLERHICGRLFGEKFRHFHALGGWGELQNTIKTFGESHPFTKLVVDLKDVDP 375

  Fly   438 --RYNTFSYAKPASVL-YMFKNAWTDKVFRTGLNKYLTKNQYTS--CDEWD--LFASFQESADEL 495
              .|::..|.|..::| |:.:.....:||...|..|:.|..|.|  .|:|.  |::.|::..|.|
Mouse   376 DVAYSSIPYEKGFALLFYLEQLLGGPEVFLGFLKAYVKKFSYQSVTTDDWKSFLYSHFKDKVDLL 440

  Fly   496 GFTLPASVDDIFSSWSHQAGYPLLTVTRNYNA----GTITITQKRYVANKTDTNSATWYVPLNFA 556
            .     .||  :::|.:..|.|  .|..||:.    ..|.::|:...|.:.|.:|        |:
Mouse   441 N-----QVD--WNTWLYAPGLP--PVKPNYDVTLTNACIALSQRWVTAKEEDLSS--------FS 488

  Fly   557 TANKYDYRDTSATHYLLNVTE 577
            .|:..|........:|..|.:
Mouse   489 IADLKDLSSHQLNEFLAQVLQ 509

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG31343	NP_732652.1	Peptidase_M1	57..446	CDD:279741	92/399 (23%)
		M1_APN_2	65..517	CDD:189008	112/475 (24%)
		ERAP1_C	591..886	CDD:288671
Lta4h	NP_032543.2	leuko_A4_hydro	6..608	CDD:274120	126/541 (23%)
		M1_LTA4H	6..450	CDD:189006	111/470 (24%)
		Substrate binding. /evidence=ECO:0000250|UniProtKB:P09960	135..137		1/1 (100%)
		Substrate binding. /evidence=ECO:0000250|UniProtKB:P09960	267..272		1/4 (25%)
		Leuk-A4-hydro_C	468..607	CDD:286244	10/50 (20%)
		Substrate binding. /evidence=ECO:0000250|UniProtKB:P09960	564..566

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0308
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900