DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31343 and Anpep

DIOPT Version :9

Sequence 1:	NP_732652.1	Gene:	CG31343 / 326133	FlyBaseID:	FBgn0051343	Length:	961	Species:	Drosophila melanogaster
Sequence 2:	NP_032512.2	Gene:	Anpep / 16790	MGIID:	5000466	Length:	966	Species:	Mus musculus

Alignment Length:	1018	Identity:	289/1018 - (28%)
Similarity:	483/1018 - (47%)	Gaps:	158/1018 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 LILLLAVCSLQARLILPLSLDDGQLETKGAALFATS----------------RVDDNSAGN-YRL 58
            |:.:.|||:     |:.||:...|.:.:.|...||:                .||::...| |||
Mouse    17 LLGVAAVCT-----IIALSVVYAQEKNRNAENSATAPTLPGSTSATTATTTPAVDESKPWNQYRL 76

  Fly    59 PNTTEPESYNVEL---WTNVHNGDTEFNGTVNIDIR-VLNETSNI------TLHYRQTSNFEATI 113
            |.|..|:||.|.|   .|..:.|...|.|  |..:| ..|:|:::      .|:|....|....:
Mouse    77 PKTLIPDSYRVILRPYLTPNNQGLYIFQG--NSTVRFTCNQTTDVIIIHSKKLNYTLKGNHRVVL 139

  Fly   114 ISRDVATPTAIPLTVTPELQR-EFLVL-TQTTAGEAFGANTNWTITINYTGIHRSDMGGFYISSY 176
            .:.| .|| |..:..|..::| |:||: .|.:..|    ...:.:...:.|....|:.|||.|.|
Mouse   140 RTLD-GTP-APNIDKTELVERTEYLVVHLQGSLVE----GRQYEMDSQFQGELADDLAGFYRSEY 198

  Fly   177 TDDDGEQHFLATTQFESTNARHAFPCYDEPARRANFTITIHHDPSYTAISNM--------PVNTA 233
            .:.|.:: .:||||.::.:||.:|||:||||.:|.|.||:.:..:..|:|||        |.:.:
Mouse   199 MEGDVKK-VVATTQMQAADARKSFPCFDEPAMKAMFNITLIYPNNLIALSNMLPKESKPYPEDPS 262

  Fly   234 ATSSGVTAFQTTPKMSTYLVAFIVSDFESTTG-ELNGIRQRVFSRKGKQD--QQEWALWSGLLVE 295
            .|   :|.|.:||||||||:|:|||:|::.:. ..||::..:::|....|  |.::||.....:.
Mouse   263 CT---MTEFHSTPKMSTYLLAYIVSEFKNISSVSANGVQIGIWARPSAIDEGQGDYALNVTGPIL 324

  Fly   296 SSLASYFGVPFALPKLDQAGIPDFSAGAMENWGLATYREQYMWWNKQNSTINLKTNIANIIGHEY 360
            :..|.::...:.|||.||..:|||:|||||||||.||||..:.::.|:|:|:.|..:..:|.||.
Mouse   325 NFFAQHYNTSYPLPKSDQIALPDFNAGAMENWGLVTYRESSLVFDSQSSSISNKERVVTVIAHEL 389

  Fly   361 AHMWFGDLVSIKWWTYLWLKEGFATLFSYESNDIAFPLWDTYQIFHVNDYNSALLNDALASAVPM 425
            ||.|||:||::.||..|||.||||:...|...|.|.|.|:...:..:||....:..|||||:.|:
Mouse   390 AHQWFGNLVTVAWWNDLWLNEGFASYVEYLGADYAEPTWNLKDLMVLNDVYRVMAVDALASSHPL 454

  Fly   426 T---HYVQTPSEISNRYNTFSYAKPASVLYMFKNAWTDKVFRTGLNKYLTKNQYTSCDEWDLFAS 487
            :   ..::||.:|...:::.:|:|.|||:.|..:..|:.:|:.||:.||...||::....||:..
Mouse   455 SSPADEIKTPDQIMELFDSITYSKGASVIRMLSSFLTEDLFKKGLSSYLHTYQYSNTVYLDLWEH 519

  Fly   488 FQESAD-ELGFTLPASVDDIFSSWSHQAGYPLLTVTRNYNAGTITITQKRYV----ANKTDTN-- 545
            .|::.: :.....||:|..|...|..|.|:|::||    |..|..|:||.::    :|.|..:
Mouse   520 LQKAVNQQTAVQPPATVRTIMDRWILQMGFPVITV----NTNTGEISQKHFLLDSKSNVTRPSEF 580

  Fly   546 SATWYVPLNFATANKYDYRDTSATHYLLNVTETVISDVEASSDDWIIVNIQNSGYYRTLYDTQNY 610
            :..|..|:.|..:.:.|       ||.|:|.:...:..:.||::||::||..:|||...||..|:
Mouse   581 NYIWIAPIPFLKSGQED-------HYWLDVEKNQSAKFQTSSNEWILLNINVTGYYLVNYDENNW 638

  Fly   611 GLITAALKSQPWRFHPRNRAQLLYDTYIFVSTDRLSHSILLELLGYLTNEQQYAPWSTANTILTV 675
            ..:...|::........||||:::|::...|...:..::.|:...:|..|.:|.||..|.:.|..
Mouse   639 KKLQNQLQTDLSVIPVINRAQIIHDSFNLASAKMIPITLALDNTLFLVKEAEYMPWQAALSSLNY 703

  Fly   676 YDRYLRGDDSYYNFQDFVKRLIDPIF------DKIGVNEIPGEHYLNNYLRIVLVSLACQVGSDD 734
            :.......:.|...:.::|:.:.|:|      ....||..|  ..:..|..|..:|.||..|..:
Mouse   704 FTLMFDRSEVYGPMKRYLKKQVTPLFFYFQNRTNNWVNRPP--TLMEQYNEINAISTACSSGLKE 766

  Fly   735 CYNQSANKLSEYLY--NGTAIEATLKTQAYCAGLRSTTNEIYSRVQSDLLSSSDSTDRSLFISSL 797
            |.:......|:::.  |...|...|::..||..:.....|.::.......:::...:.....|:|
Mouse   767 CRDLVVELYSQWMKNPNNNTIHPNLRSTVYCNAIAFGGEEEWNFAWEQFRNATLVNEADKLRSAL 831

  Fly   798 GCSGSTSQLLDFLRLSLDTNNSLSYSERTSLLNSAYSRSE------IGLTASL-------EFLES 849
            .||.....|          |..|||:     ||..|.|.:      |.:.:::       :|:.|
Mouse   832 ACSKDVWIL----------NRYLSYT-----LNPDYIRKQDTTSTIISIASNVAGHPLVWDFVRS 881

  Fly   850 NWE-----------AYANLSDSAKPLDAALRGIATYVVSEKQKTRLNALVDVVEAD--------G 895
            ||:           ::|||          ::|:.....||.:..:|    :..:||        |
Mouse   882 NWKKLFENYGGGSFSFANL----------IQGVTRRFSSEFELQQL----EQFKADNSATGFGTG 932

  Fly   896 PSYINDDLSTTIDSRITSNFAWLEVNRDPVLNWIEDSLKENGS 938
            ...:...|..|     .:|..|::.|:|.|..|    ..||.|
Mouse   933 TRALEQALEKT-----RANIDWVKENKDAVFKW----FTENSS 966

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31343	NP_732652.1	Peptidase_M1	57..446	CDD:279741	146/414 (35%)
		M1_APN_2	65..517	CDD:189008	164/478 (34%)
		ERAP1_C	591..886	CDD:288671	70/326 (21%)
Anpep	NP_032512.2	Cytosolic Ser/Thr-rich junction	33..68		6/34 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	42..64		2/21 (10%)
		Metalloprotease	69..966		275/959 (29%)
		M1_APN-Q_like	84..545	CDD:341064	162/472 (34%)
		Substrate binding. /evidence=ECO:0000250\|UniProtKB:P15144	351..355		3/3 (100%)
		ERAP1_C	618..945	CDD:403137	76/362 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167845891
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0308
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X67
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.850