DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31343 and AgaP_AGAP009907

DIOPT Version :9

Sequence 1:	NP_732652.1	Gene:	CG31343 / 326133	FlyBaseID:	FBgn0051343	Length:	961	Species:	Drosophila melanogaster
Sequence 2:	XP_319027.4	Gene:	AgaP_AGAP009907 / 1279320	VectorBaseID:	AGAP009907	Length:	646	Species:	Anopheles gambiae

Alignment Length:	520	Identity:	116/520 - (22%)
Similarity:	213/520 - (40%)	Gaps:	111/520 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 LLLAVCSLQARLILPLSLDDGQLETKGAALFATSRVDDNSAGNYRLPNTTEPESYNVELWTNVHN 77
            :|:.||.:.:.|                ||:..:|       ..|| :..:|.||:......:.:
Mosquito    11 VLVTVCVIVSLL----------------ALYQPAR-------TMRL-SPLDPSSYSNAQELIIRH 51

  Fly    78 GDTEFNGTVNIDIRVLNETSNITLHYRQT-SNFEATIISRDVATPTAIPLTVTPELQREFLVLTQ 141
            .|.::  |||.|...::.|:  |||::.| .:.|...:  ||:     .|||:.       |..:
Mosquito    52 VDLDW--TVNFDKSTISGTA--TLHFKLTKKDLEEVFL--DVS-----DLTVSS-------VAAK 98

  Fly   142 TTAGEAFGANTNWTI--TINYTGIHRSDMGGFYISSYTDDD------------------------ 180
            :.|||   ...:|.|  ||...|...:    .|:.:.|:|:
Mosquito    99 SNAGE---VPLDWDIGGTIENIGSKLT----IYLPTKTNDELTLVIAYETSPKASALQWLTPEQT 156

  Fly   181 -GEQHFLATTQFESTNARHAFPCYDEPARRANFTITIHHDPSYTAISNMPVNTAATSSGVTAFQT 244
             |::|....:|.::.:||...||.|.||.:..:..|:.|....|.:  |......:..||:.||.
Mosquito   157 FGKKHPYLFSQCQAIHARSILPCQDTPAVKFTYNATLRHPKEVTGL--MSAIKVGSEPGVSKFQQ 219

  Fly   245 TPKMSTYLVAFIVSDFES-TTGELNGIRQRVFSRKGKQDQ--QEWALWSGLLVESSLASYFGVPF 306
            ...:.:||:|.:|....| ..|.::.    |::.:.:.|:  :|::..:..:.:   |.....|:
Mosquito   220 KTPIPSYLLAIVVGALVSKPIGPISS----VWAEQEQIDEAAEEFSQTADFIAK---AEEICGPY 277

  Fly   307 ALPKLDQAGI-PDFSAGAMENWGLATYREQYMWWNKQNSTINLKTNIANIIGHEYAHMWFGDLVS 370
            ...:.|...: |.|..|.|||..|.......:..:|         ::|.::.||.||.|.|:||:
Mosquito   278 VWERYDLLVMPPSFPFGGMENPCLTFVTPTLLAGDK---------SLATVVAHEIAHSWTGNLVT 333

  Fly   371 IKWWTYLWLKEGFATLFSYESNDIAFPLWDTYQIFHVNDYNSAL---LNDALASAVPMTHYVQTP 432
            .:.:.:.||.||| |:| .|...:.....:..:.||.....|.|   :...||....:|..|...
Mosquito   334 NRNFEHFWLNEGF-TVF-VEGKIVGRLSGNASRDFHALHGLSELSDCIKTQLADTPELTKLVVDL 396

  Fly   433 SEI--SNRYNTFSYAKPASVLYMFKN-----AWTDKVFRTGLNKYLTKNQYTSCDEWDLFASFQE 490
            ||.  .:.::|..|.|.::.|...::     :..:..||..|:::..::..|:..:..|:..|:|
Mosquito   397 SECGPDDAFSTVPYIKGSTFLRYLEDLLGGPSKFEPFFRAYLDRFKYQSVLTNDFKQMLYEWFRE 461

Fly 491 490
Mosquito 462 461

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31343	NP_732652.1	Peptidase_M1	57..446	CDD:279741	100/425 (24%)
		M1_APN_2	65..517	CDD:189008	106/468 (23%)
		ERAP1_C	591..886	CDD:288671
AgaP_AGAP009907	XP_319027.4	leuko_A4_hydro	37..639	CDD:274120	107/470 (23%)
		M1_LTA4H	37..479	CDD:189006	107/470 (23%)
		Leuk-A4-hydro_C	497..638	CDD:286244
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0308
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810