DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31343 and AgaP_AGAP003926

DIOPT Version :9

Sequence 1:	NP_732652.1	Gene:	CG31343 / 326133	FlyBaseID:	FBgn0051343	Length:	961	Species:	Drosophila melanogaster
Sequence 2:	XP_318379.5	Gene:	AgaP_AGAP003926 / 1278754	VectorBaseID:	AGAP003926	Length:	876	Species:	Anopheles gambiae

Alignment Length:	955	Identity:	253/955 - (26%)
Similarity:	417/955 - (43%)	Gaps:	125/955 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 ILLLAVCSLQARLILPLSLDDGQLETKGAALFATSRVDDNSAGNYRLPNTTEPESYNVEL-WTNV 75
            :|.|.:||:.. :|:|:...:|                       ||.|.|.|..|::.| .|.:
Mosquito     1 MLWLVLCSVYL-VIVPVVTANG-----------------------RLSNNTLPLHYDLHLEATGL 41

  Fly    76 HNGDTEFNGTVNIDIRVLNETSNITLHYRQTSNFEATIISRDVATPTAIPLTVTPELQREFLVLT 140
            ...|..:.|.|:|.|.::::|:.:.||  ...|...:|..|......||          ...:|.
Mosquito    42 GLHDYTYRGNVSIRIAIVSDTNEVVLH--NVGNTLESICLRRCRDGEAI----------SHQLLE 94

  Fly   141 QTTAGEAFGANTN----------WTITINYTGIHRSDMGGFYISSYTDDDGEQHFLATTQFESTN 195
            ...|.|.....|:          .|:||.:......|..|||.:.|.........:|||.|:.:.
Mosquito    95 SEPASELLRIRTDRILRRADDQVITLTIVFHNTLGEDRMGFYRTQYRGAKRIPMAVATTHFQPSY 159

  Fly   196 ARHAFPCYDEPARRANFTITIHHDPSYTAISNMPVNTAA-TSSGVTA--FQTTPKMSTYLVAFIV 257
            ||.||||:|||..:..|.|||..:.|:...||.|:.|.. ...|..|  |:.||.|.||||.|::
Mosquito   160 ARLAFPCFDEPGFKTTFQITIVANGSHLVASNAPIATVTWLQDGHKAVRFERTPPMQTYLVTFLI 224

  Fly   258 SDFEST-TGELNGIRQRVFSRKGKQDQQEWALWSGLLVESSLASYFGVPFALPKLDQAGIPDFSA 321
            ::|.|. |...:|:...:.:....:...:::|.:...:.|||..|.|....|.|||...||.| .
Mosquito   225 ANFTSVHTVSPSGVEIGILAPPKDEKSLQFSLQAATALLSSLEEYTGQSLGLQKLDHVAIPRF-G 288

  Fly   322 GAMENWGLATYREQYMWWNKQNSTINLKTNIANIIGHEYAHMWFGDLVSIKWWTYLWLKEGFATL 386
            .|||||||..|.||::..:.:...:. :......||||.||..||:||...||:||||.|||||.
Mosquito   289 NAMENWGLVAYDEQFLVLSAKAHRLQ-RAQAVLTIGHETAHQLFGNLVGPAWWSYLWLSEGFATY 352

  Fly   387 FSYESNDIAFP-LWDTYQIFHVNDYNSALLNDAL----ASAVPMTHYVQTPSEISNRYNTFSYAK 446
            |.......|:| |....:.|.|...:.||:.||.    .:..|::  ..|| ||...::|.:|:|
Mosquito   353 FELLLGADAYPELLPLEESFAVRHMHPALMADAYEQHPLTVEPLS--ANTP-EIETLFDTITYSK 414

  Fly   447 PASVLYMFKNAWTDKVFRTGLNKYLTKNQYTSCDEWDLFASF--QESADELGFTLPASVDDIFSS 509
            ...:|.|...:..::.|:.|:..||.:::.......||:|||  |:..|      ..:|:.:|.|
Mosquito   415 AGCILRMINCSIGEEAFQAGVQNYLEQHRNGVVTPEDLYASFSVQQQRD------TPTVEQMFRS 473

  Fly   510 WSHQAGYPLLTVTRNYNAGTITITQKRYVANKTDTNSAT--WYVPLNFAT---ANKYDYRDTSAT 569
            |..:.|||::||.| .|...:...|:||...:..|...|  |::|:.:.|   ..:|:|:   ..
Mosquito   474 WVDKPGYPVVTVER-LNGSFVRFRQQRYHNQEVTTQDITSRWFIPITYYTNSSLGQYEYQ---PA 534

  Fly   570 HYLLNVTETVISDVEASSDDWIIVNIQNSGYYRTLYDTQNYGLITAALKSQPWRFHPRNRAQLLY 634
            .::....:.::..:|.::.|.::||.:..|:||..||.:.:..|...|.:.|    ...:|:|:.
Mosquito   535 FWMKETDQELVLQLEMNTQDVLVVNPRQIGFYRVEYDERGWSSIVDNLTTLP----SIMQAKLID 595

  Fly   635 DTYIFVSTDRLSHSILLELLGYLTNEQQYAPW--STANTILTVYDRYLRGDDSYYNFQDFVKRLI 697
            |.::......:.:.:.||:|..|.......||  :.|...:....|.|:..:    |..|:...:
Mosquito   596 DAFVLARAGLVGYELCLEMLQELATSPDPVPWLIAMAEENIGYLQRVLQSAE----FDRFLTGFV 656

  Fly   698 DPIFDKIGVNEIPGEHYLNNYLRIVLVSLACQVGSDDCYNQSANKLSEYLYNGTAIEATLKTQAY 762
            ..:||..|           |..|.:|.|.|..| :.|.:::.|....|     :..|::::.:|
Mosquito   657 GEMFDLAG-----------NVGRTLLQSQALDV-AYDWWSRLAASFIE-----SKRESSIRPRA- 703

  Fly   763 CAGLRSTTNEIYSRVQSDLLSSSDSTDRSLFISSLGCSGSTSQLLDFLRLSLD---TNNSLSYSE 824
            |  |.:...|:   ||: |:|..|.....||: .|.|....|.....|.|:|:   ..|.|:..:
Mosquito   704 C--LPTPVQEV---VQA-LVSPDDHVRERLFV-RLKCLPKQSNEPSVLLLALERIRAANLLTPGK 761

  Fly   825 RTSLLNSAYSRSEIG--LTASLEFLESNWEAYANLSDSAKPLDAALRGIATYVVSEKQKTRLNAL 887
            ..::|.|.. :|:.|  |..|::||.|      ...:.|.|:....:.:...:|.|....|..|.
Mosquito   762 LFAVLESLI-KSDPGRFLPPSVQFLSS------VPPEEASPVADRFQRLLNLIVHEVTDRRQAAQ 819

  Fly   888 VDVVEADGPSYINDDLSTTIDSRITSNFAWLEVNRDPVLNWIEDS 932
            |..:.....|.:..:......:.:||..:|.......:..::.||
Mosquito   820 VRRLMVKNSSILPANFLPHASTVMTSTISWRMKQVPKLREFVHDS 864

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31343	NP_732652.1	Peptidase_M1	57..446	CDD:279741	131/408 (32%)
		M1_APN_2	65..517	CDD:189008	145/473 (31%)
		ERAP1_C	591..886	CDD:288671	70/301 (23%)
AgaP_AGAP003926	XP_318379.5	Peptidase_M1	22..414	CDD:279741	131/408 (32%)
		M1_APN_2	30..481	CDD:189008	145/473 (31%)
		ERAP1_C	556..>721	CDD:288671	45/196 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0308
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X67
TreeFam	1	0.960	-	-
	6	5.780