DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31343 and AgaP_AGAP005728

DIOPT Version :9

Sequence 1:	NP_732652.1	Gene:	CG31343 / 326133	FlyBaseID:	FBgn0051343	Length:	961	Species:	Drosophila melanogaster
Sequence 2:	XP_556379.3	Gene:	AgaP_AGAP005728 / 1276400	VectorBaseID:	AGAP005728	Length:	1041	Species:	Anopheles gambiae

Alignment Length:	931	Identity:	259/931 - (27%)
Similarity:	422/931 - (45%)	Gaps:	127/931 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    57 RLPNTTEPESYNVELWTNVHNGDTEFNGTVNIDIRVLNETSNITLHYRQTSNFEATIISRDVATP 121
            |||....||.|.:.|..|:  ....|.|...::::|:..|..|||:........||:...|.
Mosquito   181 RLPTNVVPEHYRLTLKPNL--TALTFEGNTAVELKVVEATDRITLNALDLKLGTATVSFGDQ--- 240

  Fly   122 TAIPLTVTPELQREFLVLTQTTAGEAFGANT---NWTITINYTGIHRSDMGGFYISSYTDDDGEQ 183
               .|| ..::|.:   ..|.|....|||..   ..|:.:.::|.....|.|||.|.|....||:
Mosquito   241 ---QLT-AQDIQFD---AGQETVCFVFGAEIPPGKATLAVEFSGELNDKMKGFYRSKYFSPTGEE 298

  Fly   184 HFLATTQFESTNARHAFPCYDEPARRANFTITIHHDPSYTAISNMPV---------NTAATSSGV 239
            .:...||||:|:||..|||:||||.:|.|.|::....:..|:|||||         ||....
Mosquito   299 RYAGVTQFEATDARRCFPCWDEPAIKATFDISLIVPTNLVALSNMPVVEERPEPSDNTVHFK--- 360

  Fly   240 TAFQTTPKMSTYLVAFIVSDFESTTG-ELNGIRQRVFSRKGKQDQQEWALWSGLLVESSLASYFG 303
              |..||.|||||||.:|.:::.... ..:|:..||::..||::|..:||.....|......||.
Mosquito   361 --FDRTPVMSTYLVAVVVGEYDYVEDRSADGVLVRVYTPVGKREQGRFALDVATKVLPYYKDYFN 423

  Fly   304 VPFALPKLDQAGIPDFSAGAMENWGLATYREQYMWWNKQNSTINLKTNIANIIGHEYAHMWFGDL 368
            :.:.|||:|...|.||||||||||||.||||.::..:.:|:::..|.:||..:|||.||.|||:|
Mosquito   424 IAYPLPKMDLIAISDFSAGAMENWGLITYRETFVLVDPENTSLIRKQSIALTVGHEIAHQWFGNL 488

  Fly   369 VSIKWWTYLWLKEGFATLFSYESNDIAFPLWDTYQIFHVNDYNSALLNDALASAVPMTHYVQTPS 433
            |:::|||:|||.||:|:...:...|..||.:|.:..|..:.|..||..|.|.::.|:...|..||
Mosquito   489 VTMEWWTHLWLNEGYASFVEFLCVDHLFPDYDIWTQFVTDMYTRALELDCLRNSHPIEVPVGHPS 553

  Fly   434 EISNRYNTFSYAKPASVLYMFKNAWTDKVFRTGLNKYLTKNQYTSCDEWDLFASFQESADELGFT 498
            ||...::..||.|.|||:.|..:...|:.|:.|:|.|||::||.:....||:.:.||::.:
Mosquito   554 EIDEIFDEISYNKGASVIRMLHHYIGDEDFKRGMNLYLTRHQYNNTRTEDLWNALQEASSK---- 614

  Fly   499 LPASVDDIFSSWSHQAGYPLLTVTRNY----NAGTITITQKRYVANKTDT-NSATWYVPLNFATA 558
               .|..:.|:|..:.|:|::.|..:.    |...::|.|.::.|:..:. ..:.|.:|:|.:|
Mosquito   615 ---PVGAVMSTWIQRMGFPVVQVRSSKQLEGNRRVLSIAQSKFCADGCEAPEQSLWMIPINVST- 675

  Fly   559 NKYDYRDTSATHYLLNVTETVISDVE---ASSDDWIIVNIQNSGYYRTLYDTQNYGLITAALKSQ 620
                   .|:.:.:..|.||..:|:.   ....||:.:|....|||||.|..:.......|:|:.
Mosquito   676 -------PSSGNAVSTVLETATADITVEGVGEQDWVKINPGTIGYYRTQYPAEMLEQFLPAIKNM 733

  Fly   621 PWRFHPRNRAQLLYDTYIFVSTDRLSHSILLELLGYLTNEQQYAPWSTANTILTVYDRYLRGDDS 685
              ...|.:|..|:.|.:..|...:.|....|:::....||..|..||:.:..|......|....:
Mosquito   734 --TLPPLDRLGLIDDLFALVQAGKSSTVDALKVIDAYRNENNYTVWSSISNCLAKLQLLLAHTPA 796

  Fly   686 YYNFQDFVKRLIDPIFDKIGVNEIPGEHYLNNYLRIVLVSLACQVGSDDCYNQSANKLSEYLYNG 750
            ...|.::..||..|:.:|:|.:..|||.:|:..||.:::......|......::..:..|:..|.
Mosquito   797 EKQFSEYGVRLYQPVAEKLGWDVKPGESHLDTLLRSLVLGRLVSFGCPKTVAEAKRRFEEHAQNK 861

  Fly   751 TAIEATLKTQAYCAGLRSTTNEIYSRV-----QSDLLSSSDSTDRSLFISSLGCSGSTSQLLDFL 810
            :.:.|.|::..|.|.|:......|..:     .:||....|...|     :||..|:    :|.|
Mosquito   862 SVLPADLRSTCYRAVLQHGDLATYDEMLRLYRATDLHEEKDRISR-----ALGSIGN----VDIL 917

  Fly   811 RLSLDTNNSLSYSERTSLLNSAYSRSEI-----GLTASLEFLESNWEAYANLSDSAKPLDAALRG 870
            |..:|    .:.||.....:|.:....:     |...:.::...:|:...|
Mosquito   918 RKVID----FAMSEEVRAQDSVFVIVSVAINPKGRDMAWDYFCEHWQVLLN-------------- 964

  Fly   871 IATYVVSEKQKTRLNALVDVVEADGPSYINDDLSTTIDSRITSNFAWLEVNRDPVLNWIEDSLKE 935
                                      .|....|...:...:|.||:..|..::     :|...:|
Mosquito   965 --------------------------QYEGGFLLARLIKYLTENFSTEERAKE-----VEQFFRE 998

  Fly   936 NGSP----SLTSSITTILVSA 952
            :..|    :::.||.||.::|
Mosquito   999 HDFPGTERTVSQSIETIRLNA 1019

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31343	NP_732652.1	Peptidase_M1	57..446	CDD:279741	145/401 (36%)
		M1_APN_2	65..517	CDD:189008	163/464 (35%)
		ERAP1_C	591..886	CDD:288671	61/304 (20%)
AgaP_AGAP005728	XP_556379.3	Peptidase_M1	181..567	CDD:279741	145/402 (36%)
		M1_APN_2	189..630	CDD:189008	163/464 (35%)
		ERAP1_C	704..1014	CDD:288671	72/369 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0308
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X67
TreeFam	0	0.000	Not matched by this tool.
	5	4.820