DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31343 and AgaP_AGAP003695

DIOPT Version :9

Sequence 1:	NP_732652.1	Gene:	CG31343 / 326133	FlyBaseID:	FBgn0051343	Length:	961	Species:	Drosophila melanogaster
Sequence 2:	XP_313478.5	Gene:	AgaP_AGAP003695 / 1274368	VectorBaseID:	AGAP003695	Length:	920	Species:	Anopheles gambiae

Alignment Length:	979	Identity:	285/979 - (29%)
Similarity:	468/979 - (47%)	Gaps:	148/979 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 LILPLSLDDGQLETKGAALFATSRVD----------DNSAGNYRLPNTTEPESYNVELWTNVHNG 78
            |.:||:|              .||||          :.::.:|||...:||..|  :|:.::.:.
Mosquito    11 LFIPLAL--------------YSRVDGTSISLLQNEETTSDSYRLLAVSEPLYY--DLYLDMTDA 59

  Fly    79 D-TEFNGTVNIDIRVLNETSNITLHYRQTSNFEATI-ISRDVATPTAIPL---TVTPELQREFLV 138
            : :.:.|:|:|.|:.....|..:|:....:..|.|: :.|  ...|.:||   ||:.:.::.:..
Mosquito    60 NFSNYAGSVDITIKYTGNGSIFSLNSVDLAINEETLRVER--MNGTKVPLESFTVSRQFEQLYFN 122

  Fly   139 LTQTTAGEAFGANTNWTITINYTGIHRSDM-GGFYISSYTDDDGEQHFLATTQFESTNARHAFPC 202
            .|     |...:..::.:.:.:.|..::|: .|.|.|||. .|||..:||||.|.:|.||..|||
Mosquito   123 CT-----EKLESGASYNVHLEFNGTIKTDIFKGVYRSSYR-VDGEIKYLATTFFAATYARTVFPC 181

  Fly   203 YDEPARRANFTITIHHDPSYTAISNMPV--NTAATSSGVTAFQTTPKMSTYLVAFIVSDFE--ST 263
            ||||..:|.|.:.|.|...:||:|||||  :|.......|.|.|||.||||||||:||:.:  |:
Mosquito   182 YDEPGHKARFNVKIRHRSHHTALSNMPVIRSTMIDGYSETTFDTTPLMSTYLVAFVVSEMKTLSS 246

  Fly   264 TGELNGIRQRVFSRKGKQDQQEWALWSGLLVESSLASYFGVPFALPKLDQAGIPDFSAGAMENWG 328
            ..||    .||::.:.|.:...:|....:....:|.::||....:.|:|..|||||:.|||||||
Mosquito   247 VDEL----FRVYAPENKVNYTVYAHDFAVRAVRALENHFGRQNQMRKIDLVGIPDFAMGAMENWG 307

  Fly   329 LATYREQYMWWNKQNSTINL-KTNIANIIGHEYAHMWFGDLVSIKWWTYLWLKEGFATLFSYESN 392
            :.|:||.|:.:..:..|..| |..||::|.||..|||||:.|:.:||||:||.||||..|.|...
Mosquito   308 MITFREDYLIYQDEEETTALAKQKIASVITHELVHMWFGNEVTPEWWTYVWLNEGFANFFEYYIT 372

  Fly   393 DIAFPLWDTYQIFHVNDYNSALLNDALASAVPMTHYVQTPSEISNRYNTFSYAKPASVLYMFKNA 457
            ....|.|..:..|.:::.:.||..|:.:|..||.:|...|:.::..|:...|.|.|||:.|.:|.
Mosquito   373 SQLEPAWRLWDQFILDNVHWALSKDSHSSVRPMNYYATDPAVLNGLYDYVVYQKSASVIRMIQNV 437

  Fly   458 WTDKVFRTGLNKYLTKNQYTSCDEWDLFASFQE--SADELGFTLPASVDDIFSSWSHQAGYPLLT 520
            .....|:..:|.||....|.:.....|:.|.::  :.|     |||||:.||.||::..|||::|
Mosquito   438 IGFDTFQQAINDYLRSRSYLTTRPQYLYTSIEKFRTVD-----LPASVEVIFESWANTPGYPVVT 497

  Fly   521 VTRNYNAGTITITQKRY-VANKTDT--NSATWYVPLNFAT--ANKYDYRDTSATHYLLNVTETVI 580
            |:.:....|:|.:|||: :.|:.||  .:..:|:|:|:.:  ....|:.||:.|.:|.....|..
Mosquito   498 VSIDRTTRTLTASQKRFWMPNELDTPPQNMLFYIPVNYGSNVPTSTDFEDTTPTFWLTPQDPTAT 562

  Fly   581 SDVEASSDDWIIVNIQNSGYYRTLYDTQNYGLITAALKSQPWRFHPR----NRAQLLYDTYIFVS 641
            ..:||.. :|::||.|.:||||..||.:::..:...|.|.  :|..:    |||||:.|......
Mosquito   563 VSLEAGV-EWVVVNKQQTGYYRVNYDDESWHKLIEVLNSD--QFEDQLPVINRAQLVDDVANLAR 624

  Fly   642 TDRLSHSILLELLGYLTNEQQYAPWSTANTILTVYDRYLRGDDSYYNFQDFVKRLIDPIFDKIGV 706
            ...:.:.:.|.|:.||..|.:|.||:||...|...||.......|..|:::|..|...:|::  :
Mosquito   625 AGEVGYDVALSLMQYLERETEYIPWATAYNALQHLDRMFSSHKEYNRFENYVGMLASHVFNE--M 687

  Fly   707 NEIPGEHYLNNYLRIVLVSLACQVGSDDCYNQSANKLSEYLYNGTA-IEATLKTQAYCAGLRSTT 770
            |....|.:||...|...|.|||..|.:.|.:.:...:.|.|...|. |...|:...:||
Mosquito   688 NLFDTESHLNRLHRDKSVYLACYFGVEACLDAATKIIEEALAEETLNIPKELQNAVFCA------ 746

  Fly   771 NEIYSRVQSDLLSSSD-----------STDR-----SLFISSLGCSGSTSQLLDFLRLSLDTNNS 819
                 ..:.|||...|           :||:     ..||::||||.:.: :.:|....::.|.:
Mosquito   747 -----LHKYDLLVEGDYGLEIFQKYWLATDQYQPLMDKFINALGCSRNLA-MNEFYLQMIEINET 805

  Fly   820 ---LSYSERTSLLNSAYSRSEIGLTASLEFLESNWEAY-ANLSDSAKPLDAALRGIATYVVSEKQ 880
               ::.|.:.::|||.........:|:..:|:.....: .:|:.|:  :.||.|.:|
Mosquito   806 ALPITVSMKNNILNSMIKGGPATRSAAFRYLKELIHTHQTSLNPSS--MQAATRALA-------- 860

  Fly   881 KTRLNALVDVVEADGPSYINDDLSTTIDSRITSNFAWLEVNRDPVLNWI------EDSLKENGSP 939
                                         :...|..|:..:...:..|:      .|...::|:.
Mosquito   861 -----------------------------QAEENLHWIAKHSGVIAKWLVEQNFEGDDDDDSGAE 896

  Fly   940 SLTS 943
            ::||
Mosquito   897 AITS 900

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31343	NP_732652.1	Peptidase_M1	57..446	CDD:279741	141/399 (35%)
		M1_APN_2	65..517	CDD:189008	161/464 (35%)
		ERAP1_C	591..886	CDD:288671	80/319 (25%)
AgaP_AGAP003695	XP_313478.5	Peptidase_M1	40..427	CDD:279741	141/400 (35%)
		M1_APN_2	50..494	CDD:189008	161/462 (35%)
		ERAP1_C	572..>838	CDD:288671	74/281 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0308
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X67
TreeFam	0	0.000	Not matched by this tool.
	5	4.820