DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31343 and AgaP_AGAP003077

DIOPT Version :9

Sequence 1:	NP_732652.1	Gene:	CG31343 / 326133	FlyBaseID:	FBgn0051343	Length:	961	Species:	Drosophila melanogaster
Sequence 2:	XP_003436384.1	Gene:	AgaP_AGAP003077 / 1273751	VectorBaseID:	AGAP003077	Length:	1054	Species:	Anopheles gambiae

Alignment Length:	941	Identity:	282/941 - (29%)
Similarity:	435/941 - (46%)	Gaps:	115/941 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    56 YRLPNTTEPESYNVELWTNVHNGDTEFNGTVNIDIRVLNETSNITLHYRQTSNFEATII------ 114
            :|||....|..|  |||.........|:|.|.|::.|...|:.|.||.::.|..| |::
Mosquito   171 FRLPRHIRPVHY--ELWLQPDLQRETFSGRVGIELNVSESTNYIVLHSKKLSITE-TVLRTLGTG 232

  Fly   115 SRDVATPTAIPLTVTPELQREFLVLTQTTAGEAFGANTNWTITINYTGIHRSDMGGFYISSYTD- 178
            :.:|....|..|   ||  .|:.|:  .|.|| .||.. :.:::.:.|.....:.|||.|.|.|
Mosquito   233 AEEVTIARAYEL---PE--HEYWVI--ETQGE-IGAGA-YRLSVQFNGSLADRIIGFYSSKYLDK 288

  Fly   179 DDGEQHFLATTQFESTNARHAFPCYDEPARRANFTITIHHDPS---YTAISNMPVNTAAT---SS 237
            .......:||::||.|.||.||||:|||..:|.:||.:.| ||   |.|:|||.|.....   |:
Mosquito   289 TTNRTRTIATSKFEPTFARQAFPCFDEPHLKAEYTIHMVH-PSGDGYAALSNMNVKETVADKPSA 352

  Fly   238 GV--TAFQTTPKMSTYLVAFIVSDFESTTGELNGIRQ--------------RVFSRKGKQDQQEW 286
            |:  |.|:.:..||||||.||||||         :.|              ||::...:|:...:
Mosquito   353 GLSTTTFERSVSMSTYLVVFIVSDF---------LHQEVLIVPEHGSSFPLRVYATPFQQENTAY 408

  Fly   287 ALWSGLLVESSLASYFGVPFALPKLDQAGIPDFSAGAMENWGLATYREQYMWWNKQNSTINLKTN 351
            ||.:...:......|||:.:.|||||.|.||||.:||||.|||.||||..:.:|.:.|:...|..
Mosquito   409 ALATARTIIEYYVKYFGIAYPLPKLDMAAIPDFVSGAMETWGLVTYRETSILYNSETSSTANKQR 473

  Fly   352 IANIIGHEYAHMWFGDLVSIKWWTYLWLKEGFATLFSYESNDIAFPLWDTYQIFHVNDYNSALLN 416
            :|.:|.||.||||||:||::|||..|||.||||:...|:..|.|.|.|...:.|.::|.:..|..
Mosquito   474 VAGVIAHELAHMWFGNLVTMKWWNELWLNEGFASYIEYKGMDAAHPDWGIEEQFIIDDLHGVLNL 538

  Fly   417 DALASAVPMTHYVQTPSEISNRYNTFSYAKPASVLYMFKNAWTDKVFRTGLNKYLTKNQYTSCDE 481
            ||...:.|:...|:.|::|:..::|.:|:|.|||:.|.::..|..||:.|:.:||.|..|.:...
Mosquito   539 DATLGSHPIVMSVENPNQITEIFDTITYSKGASVIRMLEDFVTPPVFQQGVKRYLEKLAYANSVS 603

  Fly   482 WDLFASFQESADELGFTLPASVDDIFSSWSHQAGYPLLTVTRNYNAGTITITQKRYVANKTDTNS 546
            .||.....|...::      ||.|:..:::.|.|.|::||..  ||....:.|:|::|:: |.|.
Mosquito   604 EDLMRELDELVPDV------SVTDVMDTFTRQKGLPVVTVAE--NALQYVLRQQRFLADQ-DANE 659

  Fly   547 A-------TWYVPLNFATANKYDYRDTSATHYL-----LNVTETVISDVEASSDDWIIVNIQNSG 599
            .       .||:|:.:..:.  |...|:|...:     .:..|.||.....||  ||.:|.:..|
Mosquito   660 TEESPYGYRWYIPITYLAST--DDPATAAPRRIWFPNDASRPELVIDKPAGSS--WIKLNYRQIG 720

  Fly   600 YYRTLYDTQNYGLITAALKSQPWRFHPRNRAQLLYDTYIFVSTDRLSHSILLELLGYLTNEQQYA 664
            |||..|....:.....||:.:...|...:|..||.|.:.......|:::..|||..||:.|.:|.
Mosquito   721 YYRVNYPIAMWQQFGEALRKEVNTFTIGDRTGLLNDAFALADASLLAYNHALELTRYLSGETEYV 785

  Fly   665 PWSTANTILTVYDRYLRGDDSYYNFQDFVKRLIDPIFDKIGVNEIPGE-HYLNNYLRIVLVSLAC 728
            |||...:.|......|....||.:...:.:.|:|.....:|. |:|.| .::.|.||..::.|||
Mosquito   786 PWSAIASKLKNIRNLLYNYQSYDDITTYTQTLVDAAVKSVGW-EVPAEGGHMTNLLRTTILDLAC 849

  Fly   729 QVGSDDCYNQSANKLSEYLYNGTAIEATLKTQAYCAGLRS-TTNEIYSRVQSDLLSSSDSTDRSL 792
            ..|...|..:::.:...:|..|..|...|::..|..|::| .|...:.:|.......:|:.:::.
Mosquito   850 SFGHPACLEEASKQFRGWLNAGAVIHPDLRSVVYTYGIQSGVTVADWDKVLERFRQENDANEKTK 914

  Fly   793 FISSLGCSGSTSQLLDFLRLSLDTNNSLSYSERTSLLNSAYSRSEIGLTASLEFLESNWEAYANL 857
            .:.:|........:..||.||.||....:..:.:.:...|.:|:  |..|:.|.:..||.
Mosquito   915 LMVALASYPDQRTMRRFLDLSWDTALVRTQDQLSCIQYIAANRA--GEQAAWEHVRENWP----- 972

  Fly   858 SDSAKPLDAALRGIATYVVSEKQ--------------KTRLNALVDVVEADGPSYINDDLSTTID 908
                       |.:|.:.:.|:.              :.||..|.|.......|...........
Mosquito   973 -----------RLVARFGIGERNLGRMIPSVTGRFTTQARLTELEDFFARYPESGAGATARRQAL 1026

  Fly   909 SRITSNFAWLEVNRDPVLNWIEDSLKENGSP 939
            ..|.:|.:|||.|...|..|    |||..:|
Mosquito  1027 ENIQNNISWLERNEANVAAW----LKEATAP 1053

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31343	NP_732652.1	Peptidase_M1	57..446	CDD:279741	152/417 (36%)
		M1_APN_2	65..517	CDD:189008	169/480 (35%)
		ERAP1_C	591..886	CDD:288671	72/310 (23%)
AgaP_AGAP003077	XP_003436384.1	Peptidase_M1	172..569	CDD:279741	152/418 (36%)
		M1_APN_2	180..633	CDD:189008	169/480 (35%)
		ERAP1_C	712..1028	CDD:288671	75/334 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X67
TreeFam	0	0.000	Not matched by this tool.
	4	3.920