DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31343 and AgaP_AGAP002508

DIOPT Version :9

Sequence 1:	NP_732652.1	Gene:	CG31343 / 326133	FlyBaseID:	FBgn0051343	Length:	961	Species:	Drosophila melanogaster
Sequence 2:	XP_312430.5	Gene:	AgaP_AGAP002508 / 1273453	VectorBaseID:	AGAP002508	Length:	1057	Species:	Anopheles gambiae

Alignment Length:	951	Identity:	309/951 - (32%)
Similarity:	487/951 - (51%)	Gaps:	82/951 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    51 NSAG-----NYRLPNTTEPESYNVELWTNVHN---GDT--EFNGTVNIDIRVLN--ETSNITLHY 103
            |||.     ||||||.|.|..||:||.|::|:   ||.  .|.|.|.|.::...  :|.|:||:|
Mosquito    30 NSAAQDEQLNYRLPNNTYPLRYNIELTTHIHDNTIGDDRFRFEGKVTIQLKTAGDADTDNVTLNY 94

  Fly   104 RQTS------------NFEATIISRDVATPTAIPLTVTPELQREFLVLTQTTAGEAFGANTNWTI 156
            |:.:            .:|..::..:        |:.|.:..||||     |.......|..:.:
Mosquito    95 RRINITRVKLWYNDQDGWENILLDDE--------LSFTLDSTREFL-----TVHSPKPLNGTYFL 146

  Fly   157 TINYTGIHRSDMGGFYISSYTDDDGEQHFLATTQFESTNARHAFPCYDEPARRANFTITIHHDPS 221
            .|.|.|..|.|.||||.|||::.||...:||||||..|:|||.|||||||..||...:.:.|..|
Mosquito   147 EIKYNGTLREDNGGFYRSSYSESDGNVQWLATTQFSPTDARHVFPCYDEPGIRAPIALRVIHGKS 211

  Fly   222 YTAISN-MPVN---TAATSSGVTAFQTTPKMSTYLVAFIVSDFESTTGELNGIRQRVFSRKGKQD 282
            |:.:|| :|::   :......:|.|..||||.:||:..|||||:..:.. |...|..|.|....:
Mosquito   212 YSVLSNTIPIDVRESILAGMSITTFPDTPKMPSYLLGIIVSDFKEVSLP-NFTAQSAFIRATALN 275

  Fly   283 Q--QEWALWSGLLVESSLASYFGVPFALPKLDQAGIPDFSAGAMENWGLATYREQYMWWNKQNST 345
            .  .::.|.:|..:...|..:...|:.||||....|||||.|||||:||.||:|:...::...|.
Mosquito   276 APVADFILEAGFKILQYLEEFLETPYILPKLYHVAIPDFSPGAMENYGLITYKEENFMFDPDTSP 340

  Fly   346 INLKTNIANIIGHEYAHMWFGDLVSIKWWTYLWLKEGFATLFSYESNDIAFPLWDTYQIFHVNDY 410
            :..|..||:|:|||..|.:||:.||..||:|||:|||||..|.|.:..||||.....:::.|:..
Mosquito   341 MKQKKKIASIVGHEIGHHYFGNYVSPAWWSYLWMKEGFARFFEYTAAQIAFPELTIGKMYTVDKT 405

  Fly   411 NSALLNDALASAVPMTHYVQTPSEISNRYNTFSYAKPASVLYMFKNAWTDKVFRTGLNKYL---- 471
            ::....|||.|..|||.||.:..||||.::..:|.|..:||.|..:|:..:.||..:..:|
Mosquito   406 HNVFQLDALGSTRPMTFYVNSQVEISNIFDDIAYDKGGAVLLMLYHAFGKEPFRQAMVNFLHVNA 470

  Fly   472 ----TKNQYTSCDEWDLFASFQESADELGFTLPASVDDIFSSWSHQAGYPLLTVTRNYNAGTITI 532
                |..::....:..:|:|...:..      |.:...:..||:.|||||:|.|:|:.:..::.|
Mosquito   471 LQAGTPEKFAQSMQQTMFSSIPPTDP------PFNALSLLKSWTEQAGYPILHVSRSDDNCSLRI 529

  Fly   533 TQKRYVANKTDTNSA--TWYVPLNFATANKYDYRDTSAT------HYLLNVTETVISDVEASSDD 589
            .|:|::...||.::|  ||.:|.||||..:.::.||:||      ::::|.|    :|...:.|.
Mosquito   530 EQERFLLKSTDASNATSTWIIPYNFATETQPNFDDTTATGWIVDKYHVINPT----ADHSWTCDS 590

  Fly   590 WIIVNIQNSGYYRTLYDTQNYGLITAALKSQPWRFHPRNRAQLLYDTYIFVSTDRLSHSILLELL 654
            ||:.|.|.:||||..||.:.:.||..||.......|..|||||:.|........:|:::|.|:||
Mosquito   591 WIVFNKQQTGYYRVNYDDELWLLIVKALVQNGTIIHESNRAQLIDDALNIARAGKLAYAIPLQLL 655

  Fly   655 GYLTNEQQYAPWSTANTILTVYDRYLRGDDSYYNFQDFVKRLIDPIFDKIGVNEIPGEHYLNNYL 719
            .||:.|..|.||:..:..|.|.|..:||.|||.::..:....|:|.:.::|:...|.:.......
Mosquito   656 RYLSKENDYLPWAALDRNLVVLDNLMRGTDSYDDWHKYCSEFIEPSYVEMGMVTQPQDTLTQRMT 720

  Fly   720 RIVLVSLACQVGSDDCYNQSANKLSEYLYNGTA-IEATLKTQAYCAGLRSTTNEIYSRVQSDLLS 783
            |.::::.||:|||:.|.|.:...::|...|.|. .|..|:...||.|||.:...::..:...:..
Mosquito   721 REIVINWACKVGSEACINSTRLMVAEIAGNPTKDAEPDLREAIYCNGLRYSAAAVFDSIWRKMQQ 785

  Fly   784 SSDSTDRSLFISSLGCSGSTSQLLDFLRLSLDTNNSLSYS-ERTSLLNSAYSRSEIGLTASLEFL 847
            |.|...||..|.||||:.:...:..:|:.::||:||..:: ||..:..:.:..|.:||..::.||
Mosquito   786 SQDQLYRSELIRSLGCAENAKLIAKYLQSTIDTDNSTYFNQERERVFIAVFRNSLLGLEMAMNFL 850

  Fly   848 ESNW----EAYANLSDSAKPLDAALRGIATYVVSEKQKTRLNALVDVVEADGPSYINDDLSTTID 908
            ..|.    |.|...:...:.:::.:|.:|..:.|:..:|:...|...:...|....:|.|.....
Mosquito   851 RENSDRVNELYNKGNFGGRAINSIIRTMAQQITSKAMQTKFQTLTAELHEKGFLRESDMLQALEY 915

  Fly   909 SRITSNFAWLEVNRDPVLNWIEDSLK--ENGSPSLTSSITT 947
            |  :.|..|:|.....:..|:::..:  .|..||.|  :||
Mosquito   916 S--SENLKWIEEKSVQITAWLDEQYRPTTNALPSTT--VTT 952

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31343	NP_732652.1	Peptidase_M1	57..446	CDD:279741	156/413 (38%)
		M1_APN_2	65..517	CDD:189008	167/484 (35%)
		ERAP1_C	591..886	CDD:288671	89/300 (30%)
AgaP_AGAP002508	XP_312430.5	Peptidase_M1	41..442	CDD:279741	156/414 (38%)
		M1_APN_2	49..514	CDD:189008	167/484 (35%)
		ERAP1_C	592..914	CDD:288671	93/321 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0308
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X67
TreeFam	1	0.960	-	-
	7	6.880