DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31343 and AgaP_AGAP000129

DIOPT Version :9

Sequence 1:	NP_732652.1	Gene:	CG31343 / 326133	FlyBaseID:	FBgn0051343	Length:	961	Species:	Drosophila melanogaster
Sequence 2:	XP_311017.4	Gene:	AgaP_AGAP000129 / 1272139	VectorBaseID:	AGAP000129	Length:	953	Species:	Anopheles gambiae

Alignment Length:	986	Identity:	212/986 - (21%)
Similarity:	381/986 - (38%)	Gaps:	172/986 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    50 DNSAGN-----YRLPNTTEPESYNVELWTNVHNGDTEFNGTVNIDIRVLNETSNITLHYRQ---T 106
            |.||.|     .:||....|..|::.|...:..  :.|:|.|||.:.....|:.|.||...   .
Mosquito    34 DLSAANPLISDTKLPTDLVPSGYSLHLHPVLDR--SIFSGRVNITLLCAKATNQINLHAHHDLTV 96

  Fly   107 SNFEATIIS-RDVATPTAIPLTVTPELQREFLVL----TQTTAGEAFGANTNWTITINYTGIHRS 166
            ...|..::. .:....|.:|:.....:.::.|::    ...|||.|:      .:.:.:.|....
Mosquito    97 DELELEVVRIGEAEGGTKVPIRRVDRVPKKPLLVIYFHDALTAGAAY------EVRLRFVGNIWE 155

  Fly   167 DMGGFYISSY-------------TDDDG----EQHFLATTQFESTNARHAFPCYDEPARRANFTI 214
            ::.|.:...|             |:.:|    |:|....|.|...:||..|||:|||:.:..|.:
Mosquito   156 NVEGIFEGKYKQQQSTGPSEPAGTESEGVTEPEEHSFIGTYFRPHHARRVFPCFDEPSYKVPFNV 220

  Fly   215 TI-----HHDPSYTAISNMPVNTAATSSG---VTAFQTTPKMSTYLVAFIVSDFESTTGELNGIR 271
            :|     ||....||:.    .|..|..|   :..|:.|..|||:...|:|||.:..|..|:..:
Mosquito   221 SIVRPRTHHVLFNTALE----RTVETGDGKHVIDVFKQTAPMSTFTFGFLVSDLQQVTPSLSDEK 281

  Fly   272 Q--------RVFSRKGKQ----DQQEWALWSGLLVESSLASYFGVPFALPKLDQAGIPDFS-AGA 323
            :        ||::|:..|    |.|:..    .|....|..|:|||..|.|||...:|.|| ...
Mosquito   282 EDERLKPTIRVWARRDFQKNVADVQQRV----KLALRKLQEYWGVPLPLEKLDVVALPGFSYVKP 342

  Fly   324 MENWGLATYREQYMWWNKQNSTINLKTNIANIIGHEYAHMWFGDLVSIKWWTYLWLKEGFATLFS 388
            .:||||..::|..:.....|            :..|..:.|.|..::..||:...:.:..|   .
Mosquito   343 ADNWGLIVFKESELMRGYYN------------LAQELVYQWLGSWITPHWWSDAHVNKAIA---G 392

  Fly   389 YESNDIAFPLWDTYQIFHVNDYNSALLNDALASAVPMTHYVQTPSEISNRY---------NTFSY 444
            :.|.|.|..:..               .|......|||.......|.|.||         ...:.
Mosquito   393 FLSADTAIKIDG---------------GDEFEGKYPMTILYSIYYEFSKRYPHSRITAMKQETTC 442

  Fly   445 AKPASVLYMFKNAWTDKVFRTGLNKYLTKNQYTSC---DEWDLFASFQESADELGFTLPASVDDI 506
            :|...||.|......:..||.||.:::...:|.:.   |.|:.... |...|: ......:|:|:
Mosquito   443 SKTELVLRMLNYTLGEATFRRGLQRFIQHREYKTFYGEDVWEALTK-QAHLDQ-RLCESVTVNDV 505

  Fly   507 FSSWSHQAGYPLLTVTRNYNAGTITITQKRYVANK----TDTNSATWYVPLNFATANKYDYRDTS 567
            .:||..:...|::.|.|:|...|.|:||:.|:..:    .:.:...|::||.....::.::.:.|
Mosquito   506 VNSWITKDRIPMVRVVRSYANRTATVTQRLYLRERPHDVPEQDKMLWWIPLVVVRQDRLNFGNVS 570

  Fly   568 ATHYLLNVTETVISDVEASSDDWIIVNIQNSGYYRTLYDTQNYGLITAALKSQPWR--FHPRNRA 630
            ...::..|.|..:.:: ...|::||||.:..|.:...||.:|:.|:...|:.:..|  .....||
Mosquito   571 TIRWMKQVREVTLDEL-PGPDEFIIVNPEEIGPFPVNYDERNWNLLATFLQKEESRTMIPVYTRA 634

  Fly   631 QLLYDTYIFVSTDRLSHSILLELLGYLTNEQQYAPWSTANTILTVYDRYLRGDDSYYNFQDFVKR 695
            :||:|.:.......||......:..::..|:.:..|:...|::....|::.....:..|:.:|:.
Mosquito   635 KLLHDAWNLAYAGDLSFGTAFNMTLFMKYERNHLVWNPVFTLIDHIGRHIDMSAVHKKFEMYVRT 699

  Fly   696 LIDPIFDKIGVNEIPGEHYLNNYLRIVLVSLACQVGSDDCYNQSANKLSEYLYN-----GTAIEA 755
            |:.|:::::..|:...|......||.:..:..|:.|...|..::.....:::.:     |..:
Mosquito   700 LLTPLYEELVGNQQESEEMWKANLRSLAKNFLCRAGYKPCIEEAQRAFKKWMDSPDPDAGNPV-- 762

  Fly   756 TLKTQAYCA------------GLRSTTNEIYSRVQSDLLSSSDSTDRSLFISSL-GCSGSTSQLL 807
              ..|..|.            ||:...|...|||:|         :|:..:.:| ||.....::.
Mosquito   763 --ANQFICPVFKWGTREEWEFGLQRVINFPESRVKS---------ERTYLLKTLAGCPSQPFKID 816

  Fly   808 DFLRLSLDTNNSLSYSERTSLLNSAYSRSEIGLTASLEFLESNWEA-----------YANLSDSA 861
            ..|.:.:..:|........||:....|....|.:....||::||:|           :.|:.:||
Mosquito   817 RLLNIMVLEDNGNFTDNDISLIFKMLSGGSSGYSTLFNFLKNNWDAIKLRFKDRESLWDNMINSA 881

  Fly   862 KPLDAALRGIATYVVSEKQKTRLNALVDVVEADGPSYINDDLSTTIDSRITSNFAWLEVNRDPVL 926
            ..|.....|..  :||:.          .|:..|.....:.:.......|.....|.:.|...:.
Mosquito   882 TGLFTTQEGYD--MVSQL----------YVQHQGEFGTAEHIIEKSLKNIKEETKWSDENLPVIE 934

  Fly   927 NWIEDSLKENG 937
            .|::..|..||
Mosquito   935 QWLDHFLASNG 945

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31343	NP_732652.1	Peptidase_M1	57..446	CDD:279741	101/443 (23%)
		M1_APN_2	65..517	CDD:189008	115/509 (23%)
		ERAP1_C	591..886	CDD:288671	65/325 (20%)
AgaP_AGAP000129	XP_311017.4	GluZincin	56..512	CDD:301352	115/503 (23%)
AgaP_AGAP000129	XP_311017.4	ERAP1_C	593..916	CDD:288671	67/347 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0308
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.820